CDIP1 and OTUD7B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDIP1	OTUD7B
Description		cell death inducing p53 target 1	OTU deubiquitinase 7B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Lysosome Lysosomal Membrane Endosome Membrane Late Endosome Membrane Cytoplasmic Side Of Late Endosome Membrane Cytoplasmic Side Of Lysosomal Membrane	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	DNA Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding K48-linked Deubiquitinase Activity
	Biological Process	Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Adaptive Immune Response Immune System Process Mucosal Immune Response Proteolysis Protein Deubiquitination Negative Regulation Of Interleukin-8 Production Protein K11-linked Deubiquitination TORC1 Signaling TORC2 Signaling Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling
Pathways			TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ovarian tumor domain proteases
Drugs
Diseases
GWAS		A body shape index ( 34021172) Eosinophil percentage of white cells ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Schizophrenia ( 28991256) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer ( 29059683) Heel bone mineral density ( 30598549) Height ( 25282103) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Triglyceride levels ( 32154731) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		16 interacting genes: ATXN1 CCR2 DCUN1D1 DESI1 EPN2 LAT NEDD4 OTUB2 OTUD7B TNIP1 TOLLIP UBB UBC UBQLN1 UBQLN2 YAP1	23 interacting genes: ATG14 C1orf54 CCNB1 CDC20 CDC42SE1 CDIP1 DAZAP2 EPM2AIP1 FZR1 HSFY1 HSFY2 MINDY1 OTULIN PIK3C3 PSMB1 SAXO4 SOX2 SPART TNFAIP8L2 TRAF6 UBC UBE2S ZDHHC17
Entrez ID		29965	56957
HPRD ID		12676	10313
Ensembl ID		ENSG00000089486	ENSG00000264522
Uniprot IDs		Q9H305	Q6GQQ9
PDB IDs			5LRU 5LRV 5LRW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Metabolic Process Proteolysis Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Regulation Of Post-translational Protein Modification Post-translational Protein Modification Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Regulation Of Protein Modification Process Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Proteasomal Protein Catabolic Process Protein K11-linked Deubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cytosol Regulation Of Macromolecule Metabolic Process Protein Tag Activity Ubiquitin Binding Proline-rich Region Binding Positive Regulation Of ERAD Pathway Negative Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Cytoplasm Protein Modification By Small Protein Removal Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Macromolecule Catabolic Process Regulation Of ERAD Pathway Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of Signal Transduction Protein Modification Process Regulation Of Proteolysis Ubiquitin Conjugating Enzyme Binding Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein-containing Complex Negative Regulation Of Transport Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Macroautophagy	Positive Regulation Of Ubiquitin Protein Ligase Activity Anaphase-promoting Complex Binding Positive Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination Cell Division Positive Regulation Of Post-translational Protein Modification Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Phosphatidylinositol 3-kinase Complex, Class III Ubiquitin-protein Transferase Activator Activity Proteolysis Regulation Of Protein Ubiquitination Ubiquitin Ligase Activator Activity Protein Ubiquitination Regulation Of Protein Modification Process Protein Modification By Small Protein Conjugation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Post-translational Protein Modification Autophagosome Assembly Cytoplasm Autophagosome Organization Phosphatidylinositol-3-phosphate Biosynthetic Process Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Post-translational Protein Modification Protein Targeting To Lysosome Positive Regulation Of Catalytic Activity Phagophore Assembly Site Modification-dependent Protein Catabolic Process Regulation Of Meiotic Nuclear Division Regulation Of Nuclear Division Mitotic Cell Cycle Phase Transition Response To DDT Cell Cycle Phase Transition Metaphase/anaphase Transition Of Meiosis I Macroautophagy Extrinsic Component Of Phagophore Assembly Site Membrane Negative Regulation Of Collateral Sprouting In Absence Of Injury Perforant Pathway To Dendrate Granule Cell Synapse Protein K11-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Vacuole Organization Proteolysis Involved In Protein Catabolic Process Cellular Response To Glucose Starvation Autophagosome Maturation
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