GTF3A and GTF3C2

Number of citations of the paper that reports this interaction (PubMedID 9171097)
41

Data Source:
HPRD (in vitro)

		GTF3A	GTF3C2
Description		general transcription factor IIIA	general transcription factor IIIC subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Transcription Factor TFIIIC Complex Nucleus Nucleoplasm
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding 5S RRNA Binding Zinc Ion Binding Metal Ion Binding	RNA Polymerase III General Transcription Initiation Factor Activity DNA Binding Protein Binding
	Biological Process	Transcription By RNA Polymerase III RRNA Transcription Ribosome Biogenesis Ribosomal Large Subunit Biogenesis	Transcription By RNA Polymerase III 5S Class RRNA Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III
Pathways		RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter	RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS		Body mass index ( 20935630) Body size at age 10 ( 32376654) Night sleep phenotypes ( 27126917)	Menopause (age at onset) ( 26414677) Metabolite levels ( 23823483) Urinary albumin-to-creatinine ratio ( 32600054)
Interacting Genes		5 interacting genes: APP CHMP5 GTF3C2 OPTN SCYL2	10 interacting genes: GRIA2 GTF3A GTF3C4 MECOM PTEN RB1 SUMO2 TBP VAC14 VHL
Entrez ID		2971	2976
HPRD ID		02916	05347
Ensembl ID		ENSG00000122034	ENSG00000115207
Uniprot IDs		Q92664	Q8WUA4
PDB IDs			8CLI 8CLJ 8CLL
Enriched GO Terms of Interacting Partners?		Endosome Regulation Of Receptor Recycling Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Localization Vesicle-mediated Transport Defense Response To Gram-negative Bacterium Endosome To Lysosome Transport Acetylcholine Receptor Activator Activity Negative Regulation Of Canonical Wnt Signaling Pathway PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Recycling Endosome Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Lysosomal Transport Vacuolar Transport Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Negative Regulation Of Wnt Signaling Pathway Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Cytoplasmic Vesicle Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Negative Regulation Of Receptor Recycling Type 2 Mitophagy Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III Regulation Of Canonical Wnt Signaling Pathway Axon Choice Point Recognition Pyramidal Neuron Development	Transcription By RNA Polymerase III PML Body RNA Polymerase III General Transcription Initiation Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-templated Transcription RRNA Transcription Enzyme Binding DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Synaptic Vesicle Clustering PAS Complex Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity DNA-templated Transcription Initiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Ligand-gated Monoatomic Cation Channel Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Phosphatidylinositol Biosynthetic Process Central Nervous System Myelin Maintenance Negative Regulation Of Protein Phosphorylation Rhythmic Synaptic Transmission Chromatin Lock Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Histone H3K9 Monomethyltransferase Activity Dendritic Spine AMPA Glutamate Receptor Activity Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Myelin Sheath Adaxonal Region Negative Regulation Of Nervous System Development Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity
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