GRSF1 and FNTA

Number of citations of the paper that reports this interaction (PubMedID 32645484)
0

Data Source:
BioGRID (two hybrid)

		GRSF1	FNTA
Description		G-rich RNA sequence binding factor 1	farnesyltransferase, CAAX box, subunit alpha
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Ribonucleoprotein Granule Mitochondrial Nucleoid Ribonucleoprotein Complex	Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Complex
	Molecular Function	G-quadruplex RNA Binding Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Prenyltransferase Activity Protein Farnesyltransferase Activity Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Microtubule Binding Protein Prenyltransferase Activity Acetyltransferase Activator Activity Transferase Activity Enzyme Binding Receptor Tyrosine Kinase Binding Alpha-tubulin Binding Molecular Adaptor Activity
	Biological Process	Mitochondrial RNA Catabolic Process Positive Regulation Of Mitochondrial RNA Catabolic Process MRNA Processing TRNA Processing Anterior/posterior Pattern Specification Morphogenesis Of Embryonic Epithelium Regulation Of RNA Splicing	Nuclear Envelope Organization Enzyme-linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Peptide Pheromone Maturation Neuromuscular Junction Development Protein Farnesylation Protein Geranylgeranylation Positive Regulation Of Rac Protein Signal Transduction Protein Maturation Regulation Of Microtubule-based Movement Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways		Viral mRNA Translation Mitochondrial RNA degradation	Apoptotic cleavage of cellular proteins Inactivation, recovery and regulation of the phototransduction cascade RAS processing Potential therapeutics for SARS
Drugs			AZD3409 Lonafarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE L-778123 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Diseases
GWAS		Type 2 diabetes ( 30718926)	Zinc levels ( 26025379)
Interacting Genes		55 interacting genes: AUP1 BTBD6 CNRIP1 COMMD1 CYC1 DACT1 EIF1B ERO1A FADS2 FNTA FYN GSE1 GTF2E2 HCFC2 HIVEP3 ISYNA1 MAP6 MIR1-2 MIR106B MIR18B MIR200B MIR200C MIR205 MIR25 MIR31 MIR451A MIR9-1 MIR9-2 MIR92A1 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I NEUROD2 NOP53 NUP153 NUP93 OGT PIN1 PPIA PRNP PSMD10 RAB3A RING1 SLC25A21-AS1 UBE3C VPS11 ZNF3	22 interacting genes: ACVR1 AP4M1 CENPF CFTR FNTB GBP1 GRSF1 HDAC6 HRAS INHBB KRAS OGT PGGT1B PTP4A3 RHOB RPL13A SAFB2 STAT2 TGFB1 TGFBR1 TGM2 VAV2
Entrez ID		2926	2339
HPRD ID		07276	00607
Ensembl ID		ENSG00000132463	ENSG00000168522
Uniprot IDs		Q12849	P49354
PDB IDs		2LMI 4QU6 4QU7	1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MRNA 3'-UTR Binding Negative Regulation Of Translation MRNA Destabilization Negative Regulation Of Protein Metabolic Process RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Motility Negative Regulation Of Signal Transduction Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of MRNA Stability Positive Regulation Of Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of RNA Stability Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development	Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Anatomical Structure Morphogenesis Tissue Morphogenesis Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction GDP Binding Morphogenesis Of An Epithelium Response To Cholesterol Protein Localization To Vacuole Activin Receptor Signaling Pathway Regulation Of Protein Localization Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organismal Process Transforming Growth Factor Beta Receptor Activity, Type I Protein Prenyltransferase Activity Response To Alcohol Positive Regulation Of Developmental Process Positive Regulation Of SMAD Protein Signal Transduction Non-canonical Inflammasome Complex Assembly Myofibroblast Differentiation Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Tube Morphogenesis Activin Receptor Complex Activin Receptor Activity, Type I Regulation Of Enamel Mineralization Positive Regulation Of Mesenchymal Stem Cell Proliferation Developmental Process Morphogenesis Of A Branching Epithelium Regulation Of Establishment Of Protein Localization Response To Lipid Regulation Of Protein Localization To Cell Periphery Regulation Of Programmed Cell Death Germ Cell Migration Morphogenesis Of A Branching Structure Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Cell Migration Protein Prenylation Positive Regulation Of Cell Motility Cellular Developmental Process Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Developmental Process Prenyltransferase Activity Regulation Of Protein Localization To Membrane
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