UHRF1 and KIF11

Number of citations of the paper that reports this interaction (PubMedID 37728657)
49

Data Source:
BioGRID (enzymatic study)

		UHRF1	KIF11
Description		ubiquitin like with PHD and ring finger domains 1	kinesin family member 11
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Replication Fork Spindle Nuclear Matrix	Spindle Pole Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Spindle Microtubule Membrane Protein-containing Complex Ciliary Basal Body Mitotic Spindle
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding Transferase Activity Histone Binding Identical Protein Binding Hemi-methylated DNA-binding Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H3K9me2/3 Reader Activity DNA Damage Sensor Activity Histone H3 Ubiquitin Ligase Activity	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination DNA Repair Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Response To Stress DNA Damage Response Protein Ubiquitination Heterochromatin Formation Homologous Recombination Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Protein Autoubiquitination Mitotic Spindle Assembly	Mitotic Cell Cycle Microtubule-based Movement Spindle Organization Mitotic Spindle Organization Mitotic Centrosome Separation Regulation Of Mitotic Centrosome Separation Spindle Assembly Spindle Elongation Cell Division Mitotic Spindle Assembly Mitotic Nuclear Division
Pathways		DNA methylation Chromatin modifications during the maternal to zygotic transition (MZT)	MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs			3-[(5s)-1-Acetyl-3-(2-Chlorophenyl)-4,5-Dihydro-1h-Pyrazol-5-Yl]Phenol Monastrol Filanesib (4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE N,N-DIETHYL-2-[(2-THIENYLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE (5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE MK-0731 [(4R)-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL](PHENYL)METHANONE (2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE (1S)-1-CYCLOPROPYL-2-[(2S)-4-(2,5-DIFLUOROPHENYL)-2-PHENYL-2,5-DIHYDRO-1H-PYRROL-1-YL]-2-OXOETHANAMINE (2S)-4-(2,5-DIFLUOROPHENYL)-N,N-DIMETHYL-2-PHENYL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE (5S)-5-(3-AMINOPROPYL)-3-(2,5-DIFLUOROPHENYL)-N-ETHYL-5-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Hip circumference adjusted for BMI ( 34021172) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Mental health study participation (completed survey) ( 31263887) Systolic blood pressure ( 30578418) Type 2 diabetes ( 30297969) Urate levels ( 31578528)	Asthma ( 30929738 31619474 32296059) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Blood glucose levels ( 31928498) Inflammatory bowel disease ( 28067908) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 29785010 30054594) Pancreatic beta-cell glucose sensitivity ( 32944759) Triglyceride levels ( 31928498) Type 2 diabetes ( 21490949 31118516)
Interacting Genes		36 interacting genes: AKT1 ATR DNMT3A ERCC1 ERG FANCD2 FZR1 H2AC4 H2BC3 H3-3A H3-4 H3C1 H3C13 H3C14 H3C15 H4C14 KAT5 KIF11 LASP1 LIG1 MBD4 MUS81 NR3C1 PCLAF PCNA PLK1 PRKACA SAP30 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UHRF2 USP7	13 interacting genes: AURKA CDK1 CEBPA DCTN1 ERCC1 ERCC4 PKD2 PPARG RNF20 RNF40 SRPK2 SUMO2 UHRF1
Entrez ID		29128	3832
HPRD ID		06992	01023
Ensembl ID		ENSG00000276043	ENSG00000138160
Uniprot IDs		A0A087WVR3 Q96T88	P52732
PDB IDs		2FAZ 2L3R 2LGG 2LGK 2LGL 2PB7 3ASK 3ASL 3BI7 3CLZ 3DB3 3DB4 3DWH 3FL2 3SHB 3SOU 3SOW 3SOX 3T6R 3ZVY 3ZVZ 4GY5 4QQD 5C6D 5IAY 5XPI 5YY9 5YYA 6B9M 6IIW 6VCS 6VED 6VYJ 6W92 7FB7 8JIG 8WMS 8XV4 8XV6 8XV7 8XV8	1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2FME 2G1Q 2GM1 2IEH 2PG2 2Q2Y 2Q2Z 2UYI 2UYM 2WOG 2X2R 2X7C 2X7D 2X7E 2XAE 3CJO 3HQD 3K3B 3K5E 3KEN 3L9H 3WPN 3ZCW 4A1Z 4A28 4A50 4A51 4A5Y 4AP0 4AQV 4AQW 4AS7 4B7B 4BBG 4BXN 4CK5 4CK6 4CK7 4ZCA 4ZHI 5JV3 5ZO7 5ZO8 5ZO9 6G6Y 6G6Z 6HKX 6HKY 6TA3 6TA4 6TIW 6TLE 6TRL 6Y1I 8YHH
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus DNA Repair Nucleosome Chromosome Structural Constituent Of Chromatin Chromatin Organization Chromatin Remodeling DNA Metabolic Process DNA Damage Response DNA Binding Nucleosome Assembly Nucleosome Organization Cellular Response To Stress Chromosome Organization Protein Heterodimerization Activity Chromosome, Telomeric Region Protein-DNA Complex Assembly Macromolecule Metabolic Process Telomere Organization Negative Regulation Of Macromolecule Metabolic Process Double-strand Break Repair Negative Regulation Of Nucleobase-containing Compound Metabolic Process Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process TORC1 Signaling Response To Radiation Negative Regulation Of TORC1 Signaling Protein-containing Complex Mitotic DNA Damage Checkpoint Signaling Protein Ubiquitination Negative Regulation Of Transcription By RNA Polymerase II Mitotic DNA Integrity Checkpoint Signaling Chromatin Binding Response To Ionizing Radiation Regulation Of DNA Metabolic Process Regulation Of Chromosome Organization Ubiquitin Conjugating Enzyme Activity Response To UV TOR Signaling Cellular Response To Nutrient Levels Regulation Of Cell Cycle Protein Modification By Small Protein Conjugation Regulation Of Cellular Response To Stress Negative Regulation Of TOR Signaling	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Telomeric DNA-containing Double Minutes Formation Nucleotide-excision Repair Factor 1 Complex Negative Regulation Of Protection From Non-homologous End Joining At Telomere Positive Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Spindle ERCC4-ERCC1 Complex Negative Regulation Of Telomere Maintenance In Response To DNA Damage 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Nucleoplasm HULC Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleotide-excision Repair Complex Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Organelle Organization Negative Regulation Of Telomere Capping Regulation Of RNA Metabolic Process Chromatin Organization Spindle Regulation Of Mitotic Cell Cycle Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding Regulation Of Gene Expression Cilium Disassembly Regulation Of Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process STAT Family Protein Binding Regulation Of Macromolecule Biosynthetic Process UV Protection Macromolecule Metabolic Process Telomere Maintenance Via Recombination Regulation Of Telomere Capping Cellular Response To Stress Cilium Organization Nuclear Membrane Disassembly Nucleus Ubiquitin Protein Ligase Binding Membrane Disassembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
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