CD274 and VLDLR

		CD274	VLDLR
Description		CD274 molecule	very low density lipoprotein receptor
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Endomembrane System Actin Cytoskeleton Membrane Early Endosome Membrane Recycling Endosome Membrane Extracellular Exosome	Extracellular Space Lysosomal Membrane Plasma Membrane Clathrin-coated Pit Membrane Very-low-density Lipoprotein Particle Receptor Complex Synapse Glutamatergic Synapse
	Molecular Function	Transcription Coactivator Activity Protein Binding Receptor Ligand Activity	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Cargo Receptor Activity Reelin Receptor Activity Calcium-dependent Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway T Cell Costimulation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-10 Production Response To Cytokine TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of DNA-templated Transcription Regulation Of Activated T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Activation Regulation Of T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation	Lipid Metabolic Process Lipid Transport Endocytosis Receptor-mediated Endocytosis Signal Transduction Nervous System Development Memory Steroid Metabolic Process Cholesterol Metabolic Process Ventral Spinal Cord Development Glycoprotein Transport Very-low-density Lipoprotein Particle Clearance Reelin-mediated Signaling Pathway Dendrite Morphogenesis Regulation Of Synapse Assembly Positive Regulation Of Dendrite Development
Pathways		Co-inhibition by PD-1 STAT3 nuclear events downstream of ALK signaling Regulation of PD-L1(CD274) translation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) PD-L1(CD274) glycosylation and translocation to plasma membrane	Reelin signalling pathway VLDLR internalisation and degradation VLDL clearance
Drugs		Sildenafil Valproic acid Nivolumab Pembrolizumab Atezolizumab Durvalumab Avelumab Camrelizumab Envafolimab Cosibelimab AUNP-12 CA-170 anti-OX40 antibody BMS 986178	Lauric acid
Diseases
GWAS		Blood protein levels ( 30072576)	Alzheimer's disease (age of onset) ( 22005931) Apolipoprotein B levels ( 32203549) Cholesterol, total ( 24097068) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Gambling ( 22780124) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory biomarkers (multivariate analysis) ( 33110245) LDL cholesterol ( 30275531 24097068) LDL cholesterol levels ( 28334899 32203549) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Systolic blood pressure ( 26969751) Total cholesterol levels ( 30275531) Vascular endothelial growth factor levels ( 21757650 31217265 27989323 26910538) White blood cell count ( 32888494) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		16 interacting genes: ANXA1 CD80 COPS5 CREB1 CSNK2A1 DCAF1 HMGA1 HUWE1 ITGB1 OTUB1 PDCD1 TMUB1 UBQLN4 USP5 USP8 VLDLR	13 interacting genes: APOE CD274 CD36 CLU DAB1 DYRK1A ITSN1 LPL LRPAP1 MYLIP RELN SNX17 ZSCAN12
Entrez ID		29126	7436
HPRD ID		05655	01895
Ensembl ID		ENSG00000120217	ENSG00000147852
Uniprot IDs		Q0GN75 Q9NZQ7	A0A7P0T897 A0A7P0T8N9 A0A7P0T9P7 P98155 Q5VVF5
PDB IDs		3BIK 3BIS 3FN3 3SBW 4Z18 4ZQK 5C3T 5GGT 5GRJ 5IUS 5J89 5J8O 5JDR 5JDS 5N2D 5N2F 5NIU 5O45 5O4Y 5X8L 5X8M 5XJ4 5XXY 6L8R 6NM7 6NM8 6NNV 6NOJ 6NOS 6NP9 6PV9 6R3K 6RPG 6VQN 6YCR 7BEA 7C88 7CZD 7DCV 7DY7 7NLD 7OUN 7SJQ 7TPS 7UX5 7UXO 7UXP 7UXQ 7VUN 7XAD 7XAE 7XYQ 7YDS 8ALX 8AOK 8AOM 8JBA 8K5N 8OR1 8P1O 8R6Q 8RPB 8XR5 9INU	1V9U 3DPR 6BYV 8IHP 8UA4 8UA8 8UFB 8UFC 8X0K 8X0L 8X0M 8XI4 8XI5 8YS2 8YS4 8YVZ 8YW0 8YW1 8YW2
Enriched GO Terms of Interacting Partners?		Protein Metabolic Process Negative Regulation Of T Cell Activation Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Double-strand Break Repair Protein Modification By Small Protein Removal Protein K48-linked Deubiquitination Proteolysis Negative Regulation Of DNA Repair Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of Leukocyte Cell-cell Adhesion DeNEDDylase Activity Negative Regulation Of Lymphocyte Activation Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Cell-cell Adhesion Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Leukocyte Activation DNA Metabolic Process Protein Modification Process Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of Immune Response Negative Regulation Of Cell Activation Regulation Of Adaptive Immune Response Negative Regulation Of Adaptive Immune Response Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Protein Metabolic Process Post-translational Protein Modification Negative Regulation Of Immune Response To Tumor Cell Cysteine-type Deubiquitinase Activity DNA Repair Negative Regulation Of Apoptotic Process Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Deubiquitination Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Regulation Of T Cell Mediated Immunity Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Adhesion Regulation Of Metabolic Process Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Macromolecule Catabolic Process Cysteine-type Peptidase Activity Positive Regulation Of Metabolic Process Negative Regulation Of DNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of T-helper Cell Differentiation Proteolysis Involved In Protein Catabolic Process	Very-low-density Lipoprotein Particle Receptor Binding Low-density Lipoprotein Particle Receptor Binding Regulation Of Neurofibrillary Tangle Assembly Lipoprotein Particle Binding Receptor Ligand Activity Regulation Of Endocytosis Regulation Of Inclusion Body Assembly Amyloid-beta Binding Regulation Of Amyloid-beta Clearance Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Cellular Component Organization Amyloid-beta Clearance Plasma Lipoprotein Particle Clearance Regulation Of Vesicle-mediated Transport Lateral Motor Column Neuron Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Dendritic Spine Development Low-density Lipoprotein Particle Mediated Signaling Spinal Cord Motor Neuron Migration Positive Regulation Of Nitric Oxide Metabolic Process Tau Protein Binding Very-low-density Lipoprotein Particle Clearance Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endocytosis NMDA Glutamate Receptor Clustering Positive Regulation Of Inclusion Body Assembly Regulation Of Amyloid-beta Formation Negative Regulation Of Cellular Component Organization Regulation Of Amyloid Precursor Protein Catabolic Process Signaling Receptor Binding Regulation Of Dendritic Spine Development Receptor-mediated Endocytosis Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Protein Import Positive Regulation Of Cholesterol Storage Regulation Of Nitric Oxide Biosynthetic Process Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Amyloid-beta Clearance Cholesterol Catabolic Process Regulation Of Nitric Oxide Metabolic Process Ventral Spinal Cord Development Cholesterol Transport Nitric Oxide-cGMP-mediated Signaling Triglyceride-rich Lipoprotein Particle Remodeling Sterol Transport Regulation Of Amide Metabolic Process Reelin-mediated Signaling Pathway Neurotransmitter-gated Ion Channel Clustering Cholesterol Homeostasis Chylomicron
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