SSU72 and STAG2

Number of citations of the paper that reports this interaction (PubMedID 20818333)
32

Data Source:
BioGRID (enzymatic study)

		SSU72	STAG2
Description		SSU72 homolog, RNA polymerase II CTD phosphatase	STAG2 cohesin complex component
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex	Chromosome, Centromeric Region Chromatin Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Cohesin Complex Membrane Nuclear Matrix Mitotic Cohesin Complex Mitotic Spindle Pole
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Hydrolase Activity	Chromatin Binding Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Termination Of RNA Polymerase II Transcription MRNA Processing MRNA 3'-end Processing Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway	Chromosome Segregation Sister Chromatid Cohesion Establishment Of Mitotic Sister Chromatid Cohesion Cell Division Meiotic Cell Cycle Mitotic Spindle Assembly
Pathways		RNA polymerase II transcribes snRNA genes	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		5 interacting genes: GNB1 MAPK8 MAPK9 RAD21 STAG2	7 interacting genes: ITGB1BP2 PLK1 PTEN RAD21 SSU72 STAG1 SUMO2
Entrez ID		29101	10735
HPRD ID		13712	05077
Ensembl ID		ENSG00000160075	ENSG00000101972
Uniprot IDs		Q9NP77	Q8N3U4
PDB IDs		3O2Q 3O2S 4H3H 4H3K	4PJU 4PJW 4PK7 6QNX 7ZJS 8K4D
Enriched GO Terms of Interacting Partners?		JUN Kinase Activity Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Establishment Of Sister Chromatid Cohesion MAP Kinase Activity Fc-epsilon Receptor Signaling Pathway Sister Chromatid Cohesion Fc Receptor Signaling Pathway JNK Cascade Cellular Senescence Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Protein Localization To Chromosome JUN Phosphorylation Cellular Response To Reactive Oxygen Species Regulation Of Circadian Rhythm Protein Localization To Tricellular Tight Junction Nuclear Matrix Chromosome Segregation Positive Regulation Of MRNA Metabolic Process Response To Reactive Oxygen Species Establishment Of Meiotic Sister Chromatid Cohesion Chromosome, Centromeric Region Cellular Response To Oxygen-containing Compound Intracellular Signaling Cassette Regulation Of MRNA Stability Positive Regulation Of Protein-containing Complex Assembly Regulation Of RNA Stability Histone Deacetylase Regulator Activity Cellular Response To Oxidative Stress Basal Dendrite Meiotic Cohesin Complex Double-strand Break Repair Replication-born Double-strand Break Repair Via Sister Chromatid Exchange MAPK Cascade Rhythmic Process Cellular Response To Chemical Stress Positive Regulation Of Cellular Component Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Sister Chromatid Cohesion Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cytosol Positive Regulation Of Gene Expression Positive Regulation Of Podosome Assembly Regulation Of MRNA Metabolic Process Inflammatory Response To Wounding	Sister Chromatid Cohesion Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Establishment Of Sister Chromatid Cohesion Anaphase-promoting Complex Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Chromosome Segregation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Spindle Organization Chromosome, Centromeric Region Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Mitotic Spindle Pole Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Cell Cycle Process Protein Localization To Chromatin Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Proteolysis Regulation Of Chromosome Separation Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Chromosome Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Serine/threonine Phosphatase Activity Regulation Of Cell Cycle Phase Transition Microtubule Cytoskeleton Organization Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Mitotic Spindle Organization Spindle Assembly Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Cell Cycle Nucleoplasm Protein Localization To Chromosome Synaptonemal Complex Disassembly Golgi Inheritance Regulation Of G2/M Transition Of Mitotic Cell Cycle Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity PML Body
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