ARHGAP35 and PTPRZ1

Number of citations of the paper that reports this interaction (PubMedID 16513268)
0

Data Source:
HPRD (in vitro)

		ARHGAP35	PTPRZ1
Description		Rho GTPase activating protein 35	protein tyrosine phosphatase receptor type Z1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Ciliary Basal Body Cell Projection	Extracellular Region Plasma Membrane Membrane Extracellular Matrix Synapse Perineuronal Net
	Molecular Function	Nucleotide Binding DNA Binding GTPase Activity GTPase Activator Activity GTP Binding Phospholipid Binding Lipid Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding Hydrolase Activity
	Biological Process	Neural Tube Closure Signal Transduction Rho Protein Signal Transduction Axon Guidance Axonal Fasciculation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Cell Shape Regulation Of Cell Size Positive Regulation Of Neuron Projection Development Cell Migration Central Nervous System Neuron Axonogenesis Mammary Gland Development Forebrain Development Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Rho Protein Signal Transduction Camera-type Eye Development Negative Regulation Of Vascular Permeability Wound Healing, Spreading Of Cells Positive Regulation Of Cilium Assembly Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Neuron Projection Guidance	Hematopoietic Progenitor Cell Differentiation Protein Dephosphorylation Signal Transduction Axonogenesis Central Nervous System Development Learning Or Memory Neuron Projection Development Regulation Of Myelination Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Neuron Apoptotic Process Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation
Pathways		Sema4D mediated inhibition of cell attachment and migration PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	Other interleukin signaling MDK and PTN in ALK signaling
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33339817) Brain morphology (MOSTest) ( 32665545) Deep white matter hyperintensities ( 32517579)	Hand grip strength ( 27325353) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730)
Interacting Genes		6 interacting genes: CDC42 GRB2 KRT31 PTPRZ1 RAC1 SRC	16 interacting genes: AASS ADD2 ALK ARHGAP35 BMP1 CTNNB1 FYN GIT1 HMGB1 IL34 MDK MGAT5B NMB PTN PTPRF TNR
Entrez ID		2909	5803
HPRD ID		05592	01481
Ensembl ID		ENSG00000160007	ENSG00000106278
Uniprot IDs		Q9NRY4	B4DFE7 P23471
PDB IDs		2K85 3C5H 3FK2 6PXC 6WAY 8DGQ	3JXF 3S97 5AWX 5H08 8FN8 8FN9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Organization Anatomical Structure Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Actin Cytoskeleton Organization Thioesterase Binding Actin Filament-based Process Cytoskeleton Organization Regulation Of Protein-containing Complex Assembly Cell Differentiation Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Organelle Organization Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Angiotensin-activated Signaling Pathway GTP-dependent Protein Binding Cellular Developmental Process Positive Regulation Of Cytoskeleton Organization Cell-cell Junction Regulation Of MAPK Cascade Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell-substrate Adhesion Ephrin Receptor Binding Phagocytosis, Engulfment Regulation Of Cell Projection Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Adhesion Regulation Of Actin Filament Organization Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Lamellipodium Assembly Neuron Projection Morphogenesis Cell Projection Morphogenesis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Invagination T Cell Costimulation Substrate Adhesion-dependent Cell Spreading Regulation Of Endocytosis Positive Regulation Of Actin Filament Polymerization Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Extracellular Exosome Morphogenesis Of An Epithelium Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Regulation Of Substrate Adhesion-dependent Cell Spreading	Regulation Of Response To Wounding Cell Migration Regulation Of Oligodendrocyte Differentiation Regulation Of Neuron Projection Development Cell Motility Positive Regulation Of Neuron Projection Development Regulation Of Glial Cell Differentiation Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Developmental Process Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Cellular Component Organization Regulation Of Cell Projection Organization Leukocyte Migration Regulation Of Gliogenesis Schaffer Collateral - CA1 Synapse Positive Regulation Of Leukocyte Chemotaxis Regulation Of Axon Regeneration Regulation Of Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Development Learning Or Memory Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Glial Cell Differentiation Cell Development Nervous System Development Cognition Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration Growth Factor Activity Heparin Binding Positive Regulation Of Blood Vessel Branching Learning Positive Regulation Of Cell Projection Organization Regulation Of Multicellular Organismal Development Regulation Of Neurogenesis Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway System Development Regulation Of Blood Vessel Branching Leukocyte Chemotaxis Involved In Inflammatory Response Positive Regulation Of Gliogenesis Positive Regulation Of Epithelial Cell Proliferation Response To Mechanical Stimulus Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Positive Regulation Of Cell Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?