IFT81 and NAA25

		IFT81	NAA25
Description		intraflagellar transport 81	N-alpha-acetyltransferase 25, NatB auxiliary subunit
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytoskeleton Cilium Intraciliary Transport Particle B Motile Cilium Ciliary Basal Body Cell Projection Sperm Midpiece Sperm Principal Piece Ciliary Tip	Cytoplasm Golgi Apparatus Cytosol NatB Complex
	Molecular Function	Protein Binding Tubulin Binding	Protein Binding Acetyltransferase Activator Activity
	Biological Process	Spermatogenesis Regulation Of Smoothened Signaling Pathway Cell Projection Organization Cell Differentiation Intraciliary Anterograde Transport Intraciliary Transport Involved In Cilium Assembly Intraciliary Transport Cilium Assembly Sperm Flagellum Assembly	Cytoskeleton Organization
Pathways		Intraflagellar transport Intraflagellar transport
Drugs
Diseases			Type I diabetes mellitus
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Headache ( 29397368) Intelligence (MTAG) ( 29326435) Total intracranial volume ( 31530798)	Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence symptom count ( 29460428) Body mass index ( 26426971) Chronotype ( 30696823) Coffee consumption ( 29367735) Confectionary intake ( 33632354) Crohn's disease ( 28067908) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Epilepsy ( 33913524) Estimated glomerular filtration rate ( 31152163) Fish consumption ( 32895509) Glycated hemoglobin levels ( 34059833) Gout (combined type) ( 32238385) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 28067908) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Myocardial infarction ( 30226566) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Response to alcohol consumption (flushing response) ( 29460428) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tea consumption ( 33080986) Urate levels ( 31578528) Weight ( 34054925)
Interacting Genes		8 interacting genes: APP ERP29 HUNK NAA25 RPH3A SDS SLC8B1 TPCN1	4 interacting genes: APP ELOC FTCD IFT81
Entrez ID		28981	80018
HPRD ID		09266	08578
Ensembl ID		ENSG00000122970	ENSG00000111300
Uniprot IDs		Q8WYA0	Q14CX7
PDB IDs			6VP9 7STX 8G0L
Enriched GO Terms of Interacting Partners?		Protein Homodimerization Activity Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Amyloid-beta Complex PTB Domain Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Regulation Of Establishment Of Protein Localization Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Lymphocyte Migration Lipoprotein Particle Regulation Of Protein Transport Growth Factor Receptor Binding Main Axon Regulation Of Mononuclear Cell Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Dendritic Spine Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Secretion Regulation Of Secretion By Cell L-serine Ammonia-lyase Activity Threonine Deaminase Activity L-serine Catabolic Process Pyruvate Biosynthetic Process Sodium Ion Transmembrane Transport Intracellularly Phosphatidylinositol-3,5-bisphosphate-gated Monatomic Cation Channel Activity Voltage-gated Channel Activity NAADP-sensitive Calcium-release Channel Activity NatB Complex Calcium:sodium Antiporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential Calcium:sodium Antiporter Activity Calcium:monoatomic Cation Antiporter Activity	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Cytoskeleton-dependent Intracellular Transport Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Microtubule-based Transport Transport Along Microtubule Amylin Binding Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Target-directed MiRNA Degradation Elongin Complex L-histidine Metabolic Process L-histidine Catabolic Process L-histidine Catabolic Process To Glutamate And Formate Centriole Glutamate Formimidoyltransferase Activity L-histidine Catabolic Process To Glutamate And Formamide Formimidoyltetrahydrofolate Cyclodeaminase Activity Formate Metabolic Process Intraciliary Transport Involved In Cilium Assembly Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Smooth Endoplasmic Reticulum Membrane Peptidase Activator Activity
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