GPX3 and TP53I3

Number of citations of the paper that reports this interaction (PubMedID 22461624)
33

		GPX3	TP53I3
Description		glutathione peroxidase 3	tumor protein p53 inducible protein 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Cytosol
	Molecular Function	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Selenium Binding Oxidoreductase Activity Identical Protein Binding	Quinone Reductase (NADPH) Activity Oxidoreductase Activity Protein Homodimerization Activity Quinone Binding NADPH Binding
	Biological Process	Response To Oxidative Stress Response To Lipid Hydroperoxide Hydrogen Peroxide Catabolic Process Cellular Oxidant Detoxification	NADP+ Metabolic Process
Pathways		Detoxification of Reactive Oxygen Species	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Drugs		Glutathione Glutathione Glutathione disulfide Benzoyl peroxide
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		3 interacting genes: REEP5 TP53I3 UBQLN1	8 interacting genes: EEF1G FUNDC2 GPX3 MDM2 RAB10 UBR1 UNC119 USP2-AS1
Entrez ID		2878	9540
HPRD ID		11750	05527
Ensembl ID		ENSG00000211445	ENSG00000115129
Uniprot IDs		P22352	B4DMQ7 Q53FA7
PDB IDs		2R37	2J8Z 2OBY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Store-operated Calcium Channel Activity Quinone Reductase (NADPH) Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway
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