GPS1 and COPS2

Number of citations of the paper that reports this interaction (PubMedID 31839598)
57

Data Source:
BioGRID (cross-linking study)
HPRD (two hybrid, in vitro)

		GPS1	COPS2
Description		G protein pathway suppressor 1	COP9 signalosome subunit 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Protein-containing Complex
	Molecular Function	GTPase Inhibitor Activity Protein Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Protein Deneddylation JNK Cascade Protein Neddylation Regulation Of Protein Neddylation	Negative Regulation Of Transcription By RNA Polymerase II Protein Deneddylation Inner Cell Mass Cell Proliferation Trophectodermal Cell Proliferation Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Neuron Differentiation Skeletal Muscle Cell Differentiation Protein Neddylation Negative Regulation Of DNA-templated Transcription Regulation Of Protein Neddylation
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS			Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		26 interacting genes: CNOT2 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CUL1 CUL2 CUL3 CUL5 ELOB IP6K1 ITPK1 OGT RBX1 SAP130 SENP8 SKP1 SKP2 TBC1D17 TP53 TRIM55 TRIM63 VHL	39 interacting genes: COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CUL4A CUL5 EP300 GFER GPS1 H3C1 H4C1 ING1 ING2 IP6K1 IRF8 MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 OGT PRKD1 PSMD11 RARA RND1 RXRA SENP8 SIN3A SIN3B THRA THRB TP53 UBC VDR ZNF446
Entrez ID		2873	9318
HPRD ID		15991	05146
Ensembl ID		ENSG00000169727	ENSG00000166200
Uniprot IDs		A0A096LP07 A0A096LPJ3 A0A9L9PX62 A0A9L9PXT0 A8K070 C9JFE4 Q13098	P61201 Q59EL2
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F	4D10 4D18 4WSN 6A73 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Neddylation Protein Modification Process Regulation Of Protein Neddylation Regulation Of Post-translational Protein Modification COP9 Signalosome Ubiquitin Ligase Complex Scaffold Activity Protein Modification By Small Protein Removal Cullin-RING Ubiquitin Ligase Complex Protein Metabolic Process Protein K48-linked Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Protein Ubiquitination Regulation Of Protein Modification Process Cytosol G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Proteolysis DeNEDDylase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Nucleus Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Macromolecule Catabolic Process Catabolic Process Cell Cycle Phase Transition Protein Polyubiquitination Ubiquitin Protein Ligase Binding Proteasomal Protein Catabolic Process Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Cul5-RING Ubiquitin Ligase Complex Ubiquitin-protein Transferase Activity Protein Catabolic Process Cul2-RING Ubiquitin Ligase Complex Negative Regulation Of TORC1 Signaling Regulation Of TOR Signaling Positive Regulation Of Epithelial Cell Apoptotic Process Cytoplasm Intrinsic Apoptotic Signaling Pathway VCB Complex Negative Regulation Of TOR Signaling	Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Nucleoplasm Sin3-type Complex Negative Regulation Of Transcription By RNA Polymerase II Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Removal Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Nuclear Receptor Activity MRNA Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification Process Chromatin Regulation Of Post-translational Protein Modification MRNA Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Rhythmic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Histone Deacetylase Regulator Activity Positive Regulation Of RNA Metabolic Process Post-translational Protein Modification Regulation Of Thyroid Hormone Receptor Signaling Pathway DeNEDDylase Activity Negative Regulation Of Stem Cell Population Maintenance Retinoic Acid-responsive Element Binding Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Protein Metabolic Process Regulation Of Protein Modification Process Cytosol
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