RTP5 and ACTN2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		RTP5	ACTN2
Description		receptor transporter protein 5 (putative)	actinin alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Extracellular Region Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Sarcomere Z Disc Cell Junction Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Synapse Extracellular Exosome Postsynaptic Density Membrane Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Protein Binding Zinc Ion Binding Olfactory Receptor Binding Metal Ion Binding	Transcription Coactivator Activity Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Protein Domain Specific Binding LIM Domain Binding Titin Binding Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding FATZ Binding Titin Z Domain Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity
	Biological Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Protein Targeting To Membrane Protein Insertion Into Membrane	Cell Adhesion Microspike Assembly Actin Cytoskeleton Organization Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Sarcomere Organization Positive Regulation Of DNA-templated Transcription Focal Adhesion Assembly Anatomical Structure Formation Involved In Morphogenesis Actin Filament Uncapping Muscle Cell Development Cardiac Muscle Cell Development Protein Localization To Plasma Membrane Phospholipase C-activating Angiotensin-activated Signaling Pathway Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Endocytic Recycling Positive Regulation Of Cation Channel Activity
Pathways			Platelet degranulation Nephrin family interactions Striated Muscle Contraction Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases
GWAS			Metabolite levels ( 23823483) Periodontitis (CDC/AAP) ( 24024966)
Interacting Genes		51 interacting genes: ACTN2 ACTN3 AKAP8L APOC1 ASPG BEND5 BPIFA1 CALCOCO2 CARD9 CBY2 CIDEB COG6 DOCK8 EIF3F FGF14 GOLGA2 GOLGA6L9 HNRNPK HSF2BP KIFAP3 KRT27 KRT31 KRT33B KRT34 KRT40 KRT86 KRTAP19-5 KRTAP6-2 LZTS2 MDFI MIPOL1 MIS18A MKRN3 MTUS2 NFKBID PDE4DIP PNMA1 PNMA2 PSMA3 PSMA6 PSTPIP1 RBPMS RINT1 ROPN1 SERTAD3 SP100 SPDL1 TRAF1 TRIM23 TSGA10 USHBP1	111 interacting genes: ACTN3 ADAM12 ADORA2A AKAP8L AKTIP ANG ANGPTL7 ARX ASH2L ATP5MC1 ATXN2 ATXN7 BAD BRMS1L CACNA1C CAMK2A CAMK2D CAMK2G CAPN1 CCDC187 CD27 CIMAP1B CLEC4D CNNM3 COIL CRABP2 CRADD DISC1 DLG1 DLG4 DUX1 DYNLT2B EPS8L1 ERBIN FAM50B FBXL22 FXR1 GATA3 GOLGA7 GRIN1 GRIN2B GSTT1 H4C9 HSPB1 HTR1B ITGB3BP KAT2B KATNAL2 KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MAST2 MED14 MICALL2 MOS MRPL10 MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 MYPN NCAPH2 NCOA2 NCOR1 NKAPD1 NOS3 NR1I2 NRIP1 NTAQ1 PALLD PDLIM1 PDLIM3 PKD2 PPP1CB PPP1R9B PSMA1 QARS1 RACK1 RAVER1 RPL35 RPP14 RTP5 SAXO1 SELE SHANK3 SMARCA2 SNAI1 SNAPIN SNW1 SP100 SPA17 SRP9 SSX2IP ST7 SYNPO2 SYNPO2L TNN TOLLIP TSC1 TSC2 TTN TULP3 USP2 UTRN ZC2HC1C ZNF446 ZNRD2
Entrez ID		285093	88
HPRD ID		08159	00019
Ensembl ID		ENSG00000188011	ENSG00000077522
Uniprot IDs		Q14D33	P35609
PDB IDs			1H8B 1HCI 1QUU 4D1E 5A36 5A37 5A38 5A4B 6SWT 6TS3 7A8T 7A8U 7B55 7B56 7B57
Enriched GO Terms of Interacting Partners?		Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Identical Protein Binding Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Protein Binding Cytoskeleton Organization Organelle Organization Cytoskeleton Structural Molecule Activity Proteasome Core Complex, Alpha-subunit Complex Very-low-density Lipoprotein Particle Assembly	Z Disc Muscle Alpha-actinin Binding Actin Binding Alpha-actinin Binding Postsynaptic Density Regulation Of Neuronal Synaptic Plasticity Sarcomere Organization Protein Binding Actin Cytoskeleton Actin Filament-based Process Telethonin Binding Organelle Organization Cytoplasm Neuron Projection Actin Cytoskeleton Organization Calmodulin Binding Actomyosin Structure Organization Cytoskeleton Organization Actinin Binding Calcium- And Calmodulin-dependent Protein Kinase Complex FATZ Binding Regulation Of Monoatomic Ion Transport Positive Regulation Of Synaptic Transmission Regulation Of Membrane Potential Dendritic Spine Cytoskeletal Protein Binding Regulation Of Synaptic Plasticity Regulation Of Transport Intracellular Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Structural Constituent Of Muscle Cell Adhesion Nuclear Receptor Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of Metal Ion Transport Regulation Of Signal Transduction Stress Fiber Regulation Of Multicellular Organismal Process Adherens Junction Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Excitatory Postsynaptic Potential Kinase Binding Locomotor Rhythm Cell Projection Organization Protein-containing Complex Localization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcium Ion Transport Calcium-mediated Signaling
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