CYB561D1 and GAD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CYB561D1	GAD2
Description		cytochrome b561 family member D1	glutamate decarboxylase 2
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Axon Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
	Molecular Function	Protein Binding Metal Ion Binding Transmembrane Ascorbate Ferrireductase Activity Transmembrane Monodehydroascorbate Reductase Activity	Glutamate Decarboxylase Activity Protein Binding Lyase Activity Carbon-carbon Lyase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding
	Biological Process	Transmembrane Transport	Gamma-aminobutyrate Shunt Chemical Synaptic Transmission Gamma-aminobutyric Acid Biosynthetic Process Carboxylic Acid Metabolic Process
Pathways			GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling
Drugs			Pyridoxal phosphate Glutamic acid
Diseases
GWAS		Chronic kidney disease ( 20383146) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive function ( 28093568) General cognitive ability ( 29844566) Major depressive disorder ( 20125088) Obesity-related traits ( 23251661) Smoking behaviour (cigarette pack-years) ( 30679032)	Fasting glucose ( 34059833) Glycated hemoglobin levels ( 34059833) Lean body mass ( 28552196)
Interacting Genes		4 interacting genes: AQP6 CFTR GAD2 TMED8	49 interacting genes: ABHD5 AGTRAP APOC2 APOC4 ARL13B ARL6IP1 ARMC12 BASP1 BSND CACNG1 CALM1 CMTM5 CPLX4 CYB561D1 DERL1 DERL3 DGAT2L6 DMKN F10 FADS6 FAM114A2 FAM163A FTCD GAD1 HIGD1C LDAF1 LIME1 MAL2 MAP3K8 MEST MRM3 PBX3 PLIN3 PRKACA PRKCE RDH10 RHEX RPRM SCAMP1 SDR16C5 SEC22A SMPD2 SPG21 SYCE2 SYNGR3 TMEM120B TMEM128 TNFRSF10D TSPAN33
Entrez ID		284613	2572
HPRD ID		09902	11817
Ensembl ID		ENSG00000174151	ENSG00000136750
Uniprot IDs		Q6ZQS1 Q8N8Q1	Q05329 Q5VZ30
PDB IDs			1ES0 2OKK 7LZ6
Enriched GO Terms of Interacting Partners?		Fluid Transport Water Transport PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Chloride Transmembrane Transport Monoatomic Anion Transmembrane Transport Inorganic Anion Transmembrane Transport Inorganic Anion Transport Odontogenesis Monoatomic Anion Transport Chloride Transport Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Transepithelial Water Transport Monoatomic Anion Channel Activity Renal Water Transport Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Gamma-aminobutyric Acid Biosynthetic Process L-glutamate Catabolic Process Gamma-aminobutyric Acid Metabolic Process Succinate Metabolic Process Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Ammonium Channel Activity Amelogenesis Carbon-carbon Lyase Activity Ammonium Transmembrane Transport ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Water Channel Activity Golgi-associated Vesicle Membrane Carbon Dioxide Transport Cellular Response To Forskolin Small Molecule Biosynthetic Process Response To Forskolin	Membrane Lipid Droplet Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Calcium Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Protein Binding Positive Regulation Of Triglyceride Catabolic Process Signal Recognition Particle Binding Substantia Nigra Development Endoplasmic Reticulum Regulation Of Lipid Storage Regulation Of Calcium Ion Transport
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