LAMA1 and NT5E

Number of citations of the paper that reports this interaction (PubMedID 10470109)
0

Data Source:
HPRD (in vivo)

		LAMA1	NT5E
Description		laminin subunit alpha 1	5'-nucleotidase ecto
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-3 Complex Extracellular Space Cell-cell Junction Membrane Extracellular Matrix Laminin Complex Protein Complex Involved In Cell-matrix Adhesion	Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Exosome Side Of Membrane
	Molecular Function	Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Glycosphingolipid Binding	Nucleotide Binding 5'-deoxynucleotidase Activity Protein Binding 5'-nucleotidase Activity Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Identical Protein Binding Metal Ion Binding
	Biological Process	Morphogenesis Of An Epithelial Sheet Cell Adhesion Cell Surface Receptor Signaling Pathway Tissue Development Regulation Of Cell Adhesion Regulation Of Cell Migration Neuron Projection Development Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Adhesion Regulation Of Embryonic Development Positive Regulation Of Muscle Cell Differentiation Retina Development In Camera-type Eye Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Retinal Blood Vessel Morphogenesis Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway	AMP Catabolic Process DNA Metabolic Process Leukocyte Cell-cell Adhesion Nucleotide Catabolic Process Response To ATP ADP Catabolic Process ATP Metabolic Process Adenosine Biosynthetic Process Negative Regulation Of Inflammatory Response Calcium Ion Homeostasis Inhibition Of Non-skeletal Tissue Mineralization
Pathways		Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells	Nicotinate metabolism Pyrimidine catabolism Purine catabolism Purinergic signaling in leishmaniasis infection
Drugs		Lanoteplase	Pentoxifylline
Diseases			Calcification of joints and arteries
GWAS		Adverse response to drug ( 30420678) Response to citalopram treatment ( 22760553) Type 2 diabetes ( 22693455 30054458 30297969 32499647)	Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lung function ( 31902109) Metabolic traits ( 21886157) Serum metabolite levels ( 33031748)
Interacting Genes		23 interacting genes: ACHE APCS APP C3 COL18A1 COL7A1 DAG1 FBLN2 HSPG2 ITGA1 ITGA2 ITGB1 MEP1A NID1 NT5E PLAT PLG SAA1 SAA2 TGM2 TMPRSS6 UBC USP7	7 interacting genes: ACTB AFF1 ATP6AP1 FN1 LAMA1 RNF24 ZNRF4
Entrez ID		284217	4907
HPRD ID		01033	00552
Ensembl ID		ENSG00000101680	ENSG00000135318
Uniprot IDs		P25391	P21589 Q6NZX3
PDB IDs			4H1S 4H1Y 4H2B 4H2F 4H2G 4H2I 6HXW 6S7F 6S7H 6TVE 6TVG 6TVX 6TW0 6TWA 6TWF 6VC9 6VCA 6XUE 6XUG 6XUQ 6YE1 6YE2 6Z9B 6Z9D 7BBJ 7JV8 7JV9 7P9N 7P9R 7P9T 7PA4 7PB5 7PBA 7PBB 7PBY 7PCP 7PD9 7QGA 7QGL 7QGM 7QGO 8ZNZ
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Laminin Binding Basement Membrane Extracellular Matrix Extracellular Region Cell Surface Extracellular Space Extracellular Matrix Organization Extracellular Structure Organization Collagen Binding Involved In Cell-matrix Adhesion Cell Adhesion External Side Of Plasma Membrane Cell-matrix Adhesion Collagen Binding Cell-substrate Adhesion Integrin Alpha1-beta1 Complex High-density Lipoprotein Particle Integrin Alpha2-beta1 Complex Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Cell Adhesion Integrin Complex Response To Muscle Activity Calcium Ion Binding Trans-synaptic Signaling By BDNF Basement Membrane Organization Focal Adhesion Acute-phase Response Peptidase Activity Positive Regulation Of Multicellular Organismal Process Regulation Of Spontaneous Synaptic Transmission Regulation Of Wound Healing Modulation Of Chemical Synaptic Transmission Endoplasmic Reticulum Lumen Laminin-1 Binding Positive Regulation Of Cell Adhesion Integrin Binding Serine-type Endopeptidase Activity Inflammatory Response Regulation Of Apoptotic Cell Clearance Regulation Of Response To Wounding Acute Inflammatory Response Positive Regulation Of Wound Healing Proteolysis Branching Involved In Salivary Gland Morphogenesis Negative Regulation Of Fibrinolysis Trans-synaptic Signaling, Modulating Synaptic Transmission Negative Regulation Of Wound Healing Cell Migration Regulation Of Multicellular Organismal Process Regulation Of Cell Communication	Positive Regulation Of Cell Adhesion Regulation Of Transepithelial Transport Blood Microparticle Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Transporter Regulator Activity Cellular Response To Cytochalasin B Negative Regulation Of Monocyte Activation Calcium-independent Cell-matrix Adhesion Basement Membrane Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Extracellular Matrix Structural Constituent Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Laminin-1 Complex Laminin-3 Complex Laminin Complex BBAF Complex Tat Protein Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Regulation Of Cell Adhesion Nitric-oxide Synthase Regulator Activity Cell-cell Junction Postsynaptic Actin Cytoskeleton Cell Adhesion Protein Localization To Adherens Junction Positive Regulation Of Cell Differentiation Dense Body Morphogenesis Of A Polarized Epithelium Establishment Or Maintenance Of Cell Polarity Osteoclast Development Proton-transporting Two-sector ATPase Complex Golgi Lumen Acidification Peptidase Activator Activity Blood Coagulation, Fibrin Clot Formation Fibrinogen Complex Neural Crest Cell Migration Involved In Autonomic Nervous System Development Super Elongation Complex Retina Vasculature Morphogenesis In Camera-type Eye Retinal Blood Vessel Morphogenesis Regulation Of Basement Membrane Organization Glycosphingolipid Binding Protein Complex Involved In Cell-matrix Adhesion Nitric-oxide Synthase Binding Cell Junction Assembly Transporter Activator Activity Endomembrane System Integrin Activation Negative Regulation Of Transforming Growth Factor Beta Production Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Branching Involved In Salivary Gland Morphogenesis
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