PROX2 and ISM2

		PROX2	ISM2
Description		prospero homeobox 2	isthmin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Extracellular Region
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Pancreas Development Tube Development Cell Fate Commitment Positive Regulation Of Cell Cycle Anatomical Structure Formation Involved In Morphogenesis Embryonic Retina Morphogenesis In Camera-type Eye Lymphatic Endothelial Cell Differentiation Lens Fiber Cell Morphogenesis Hepatocyte Differentiation
Pathways
Drugs
Diseases
GWAS		Depression ( 29700475) Gastroesophageal reflux disease ( 34187846) Monocyte count ( 32888494) Mood instability ( 29187730) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Total cholesterol levels ( 29083408)	Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Sum neutrophil eosinophil counts ( 27863252)
Interacting Genes		6 interacting genes: ISM2 LRRC74A SAMD15 SLIRP-OT1 TMED8 ZDHHC22	2 interacting genes: PROX2 SCN3B
Entrez ID		283571	145501
HPRD ID		19081	18182
Ensembl ID		ENSG00000119608	ENSG00000100593
Uniprot IDs		G3V3G0 Q3B8N5	Q6H9L7
PDB IDs
Enriched GO Terms of Interacting Partners?			Sodium Channel Inhibitor Activity Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Atrial Cardiac Muscle Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Lens Fiber Cell Morphogenesis Lymphatic Endothelial Cell Differentiation Embryonic Retina Morphogenesis In Camera-type Eye Voltage-gated Sodium Channel Complex Hepatocyte Differentiation Membrane Depolarization During Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Sodium Channel Activity Sodium Channel Regulator Activity Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Sodium Ion Transport Positive Regulation Of Heart Contraction System Development Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Positive Regulation Of Heart Rate Pancreas Development Endothelial Cell Differentiation Cardiac Muscle Contraction Cardiac Conduction Regulation Of Membrane Depolarization Membrane Depolarization Regulation Of Sodium Ion Transport Striated Muscle Contraction Regulation Of Heart Rate Action Potential Monoatomic Ion Channel Complex
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