ANG and CRIPTO

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ANG	CRIPTO
Description		angiogenin	cripto, EGF-CFC family member
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Nucleus Chromosome Nucleolus Cytoplasm Cytosol Cytoplasmic Stress Granule Actin Cytoskeleton Endocytic Vesicle Growth Cone Angiogenin-PRI Complex Neuronal Cell Body	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Membrane Raft Side Of Membrane
	Molecular Function	Nucleic Acid Binding DNA Binding Actin Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity RNA Nuclease Activity TRNA-specific Ribonuclease Activity Signaling Receptor Binding Copper Ion Binding Protein Binding Heparin Binding Hydrolase Activity RRNA Binding Peptide Binding Protein Homodimerization Activity Ribosome Binding Receptor Ligand Activity	Signaling Receptor Binding Protein Binding Growth Factor Activity Nodal Binding Activin Receptor Binding
	Biological Process	Angiogenesis Ovarian Follicle Development Oocyte Maturation Response To Hypoxia Response To Yeast Placenta Development Positive Regulation Of Endothelial Cell Proliferation Cytoplasmic Translation Receptor-mediated Endocytosis Cell Communication Signal Transduction RRNA Transcription Response To Hormone TRNA Decay Cell Migration Negative Regulation Of Translation Antibacterial Humoral Response Antifungal Humoral Response Signaling Actin Filament Polymerization Cell Differentiation Negative Regulation Of Translation In Response To Stress Cellular Response To Stress Stress Granule Assembly TRNA Stabilization Positive Regulation Of Phosphorylation Homeostatic Process Negative Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Hematopoietic Stem Cell Proliferation	Blood Vessel Development Morphogenesis Of A Branching Structure Cell Migration Involved In Sprouting Angiogenesis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Determination Of Left/right Symmetry Heart Development Positive Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Ending In Birth Or Egg Hatching Anterior/posterior Pattern Specification Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Cell Differentiation Positive Regulation Of Cell Migration Mammary Gland Development Cellular Response To Hepatocyte Growth Factor Stimulus Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Type II Interferon Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus
Pathways		Adherens junctions interactions tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	Signaling by NODAL Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Blood protein levels ( 30072576)
Interacting Genes		8 interacting genes: ABCG8 ACTC1 ACTN2 ATP6AP1 CRIPTO PTEN RNH1 TNFSF8	22 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ANG AP2S1 BAG6 BMP4 BMP6 BMP7 BMPR1A BMPR2 COPS6 FARSA FBLN1 GDF3 GDF9 INHBB LRIF1 NODAL TGFBR2
Entrez ID		283	6997
HPRD ID		00105	01757
Ensembl ID		ENSG00000214274	ENSG00000241186
Uniprot IDs		P03950 W0UV28	F5H1T8 P13385
PDB IDs		1A4Y 1ANG 1AWZ 1B1E 1B1I 1B1J 1GV7 1H0D 1H52 1H53 1HBY 1K58 1K59 1K5A 1K5B 1UN3 1UN4 1UN5 2ANG 4AHD 4AHE 4AHF 4AHG 4AHH 4AHI 4AHJ 4AHK 4AHL 4AHM 4AHN 4AOH 4B36 5EOP 5EPZ 5EQO 5M9A 5M9C 5M9G 5M9J 5M9M 5M9P 5M9Q 5M9R 5M9S 5M9T 5M9V 7NPM 7PNJ 7PNP 7PNR 8AF0 9BDL 9BDN 9BDP
Enriched GO Terms of Interacting Partners?		Filopodium Sarcomere Synapse Actin Filament Titin Z Domain Binding Actin Filament Uncapping Plasma Membrane Apical Plasma Membrane Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Angiogenin-PRI Complex Negative Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Intestinal Phytosterol Absorption Actomyosin Structure Organization Phospholipase C-activating Angiotensin-activated Signaling Pathway Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Ribonuclease Inhibitor Activity Nodal Binding Negative Regulation Of Intestinal Absorption	Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Activin Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Cellular Response To BMP Stimulus Cellular Response To Growth Factor Stimulus Regulation Of Ossification Positive Regulation Of Osteoblast Differentiation Regulation Of Bone Mineralization Response To Growth Factor Activin Receptor Activity, Type I Activin Binding Cell Surface Receptor Signaling Pathway Activin Receptor Activity Regulation Of Osteoblast Differentiation Growth Factor Binding Mesoderm Formation System Development Lung Development Mesoderm Development Animal Organ Development Regulation Of Multicellular Organismal Development Formation Of Primary Germ Layer BMP Receptor Activity Osteoblast Differentiation Outflow Tract Septum Morphogenesis Tissue Development Cardiac Septum Morphogenesis Growth Factor Activity Pattern Specification Process Heart Development Regulation Of Multicellular Organismal Process Activin Receptor Activity, Type II Regulation Of Reproductive Process Positive Regulation Of Cell Differentiation Developmental Process Involved In Reproduction Gastrulation Gastrulation With Mouth Forming Second Cytokine Activity Heart Valve Morphogenesis
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