XCR1 and XCL1

Number of citations of the paper that reports this interaction (PubMedID 9632725)
0

Data Source:
HPRD (in vivo)

		XCR1	XCL1
Description		X-C motif chemokine receptor 1	X-C motif chemokine ligand 1
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Extracellular Region Extracellular Space
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding	Cytokine Activity Protein Binding Chemokine Activity Chemokine Receptor Binding Protein Homodimerization Activity CCR Chemokine Receptor Binding
	Biological Process	Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Response To Cytokine Release Of Sequestered Calcium Ion Into Cytosol Cell Chemotaxis Chemokine-mediated Signaling Pathway	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of T Cell Cytokine Production Positive Regulation Of T Cell Cytokine Production Negative Regulation Of T-helper 1 Type Immune Response Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Cell Migration Neutrophil Chemotaxis Killing Of Cells Of Another Organism Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-10 Production Mature Natural Killer Cell Chemotaxis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Interleukin-4 Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Granzyme B Production Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Thymocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of B Cell Chemotaxis Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Pathways		Chemokine receptors bind chemokines G alpha (q) signalling events	Chemokine receptors bind chemokines G alpha (q) signalling events
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)	Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Metabolite levels ( 23823483) Psoriasis ( 34927100)
Interacting Genes		5 interacting genes: PLEKHF2 PRKAR2A TOPAZ1 XCL1 XCL2	21 interacting genes: CCL11 CCL13 CCL21 CCL24 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL9 FBLN5 KRTAP10-3 PF4 PF4V1 TNFSF18 VCAN XCR1
Entrez ID		2829	6375
HPRD ID		02774	02595
Ensembl ID		ENSG00000173578	ENSG00000143184
Uniprot IDs		P46094 Q502V0 Q689E2	P47992
PDB IDs		9AST	1J8I 1J9O 2HDM 2JP1 2N54 2NYZ 9AST
Enriched GO Terms of Interacting Partners?		CCR Chemokine Receptor Binding Positive Regulation Of Granzyme A Production Chemokine Activity Negative Regulation Of T-helper 1 Cell Activation Chemokine-mediated Signaling Pathway Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Mature Natural Killer Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Granzyme B Production Positive Regulation Of B Cell Chemotaxis Positive Regulation Of Thymocyte Migration Spermatocyte Division G Protein-coupled Receptor Signaling Pathway Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Natural Killer Cell Chemotaxis Regulation Of Thymocyte Migration Antimicrobial Humoral Response LncRNA Transcription Positive Regulation Of Natural Killer Cell Chemotaxis Cell Chemotaxis Cytokine Activity CAMP-dependent Protein Kinase Regulator Activity Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of T-helper 1 Cell Cytokine Production Humoral Immune Response Regulation Of CD8-positive, Alpha-beta T Cell Proliferation CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T-helper 2 Cell Cytokine Production Chemokine Receptor Binding Nucleotide-activated Protein Kinase Complex Negative Regulation Of T Cell Cytokine Production Negative Regulation Of T-helper 1 Type Immune Response Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Chemotaxis Protein Kinase A Catalytic Subunit Binding Positive Regulation Of T Cell Chemotaxis Locomotion Regulation Of T Cell Chemotaxis Negative Regulation Of Alpha-beta T Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Type 2 Immune Response Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of T-helper 1 Type Immune Response Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Lymphocyte Chemotaxis Ectopic Germ Cell Programmed Cell Death CAMP Binding Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cytokine Activity Antimicrobial Humoral Response Chemotaxis Locomotion Leukocyte Chemotaxis Humoral Immune Response Leukocyte Migration Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Myeloid Leukocyte Migration Cell Migration Granulocyte Migration Cell Motility Killing Of Cells Of Another Organism Extracellular Space Cell Killing Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism CXCR Chemokine Receptor Binding Immune System Process Defense Response Extracellular Region Response To Other Organism Eosinophil Chemotaxis Eosinophil Migration Mononuclear Cell Migration CCR Chemokine Receptor Binding Response To External Biotic Stimulus CXCR3 Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Cell Migration Regulation Of Monocyte Chemotaxis Positive Regulation Of Leukocyte Migration Chemokine Receptor Binding Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell-cell Signaling Signaling Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Cell Communication
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