CCR10 and RAB5C

		CCR10	RAB5C
Description		C-C motif chemokine receptor 10	RAB5C, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Lysosomal Membrane Endosome Early Endosome Lipid Droplet Plasma Membrane Endomembrane System Membrane Endocytic Vesicle Early Endosome Membrane Azurophil Granule Membrane Melanosome Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding
	Biological Process	Chemotaxis Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway	Intracellular Protein Transport Endocytosis Endosome Organization Protein Transport Endosomal Transport Regulation Of Endocytosis Plasma Membrane To Endosome Transport
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Golgi Associated Vesicle Biogenesis Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Respiratory syncytial virus (RSV) attachment and entry
Drugs
Diseases
GWAS			Coronary artery disease ( 29212778) Fibrinogen levels ( 26561523 28107422) Mean corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737) White blood cell count ( 32888494)
Interacting Genes		11 interacting genes: ARPC3 CCL19 CCL2 CCL25 CCL27 CCL28 CCL7 CCR7 CXCL13 PRRC2A RAB5C	23 interacting genes: ALS2CL APP APPL2 CCR10 DGKI EEA1 ERBB2 GLP1R HOXB13 HRAS INCA1 KRT15 RABAC1 RAPGEFL1 RBSN RIN2 RIN3 SGSM3 SLC27A2 SNCA SREK1 TBC1D15 TBC1D17
Entrez ID		2826	5878
HPRD ID		02586	04947
Ensembl ID		ENSG00000184451	ENSG00000108774
Uniprot IDs		P46092	P51148
PDB IDs			4KYI
Enriched GO Terms of Interacting Partners?		Chemokine Activity Myeloid Leukocyte Migration Leukocyte Chemotaxis Granulocyte Chemotaxis Granulocyte Migration Cell Chemotaxis Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Chemotaxis Chemokine-mediated Signaling Pathway Locomotion Cytokine Activity Regulation Of Leukocyte Migration Chemokine Receptor Binding Humoral Immune Response Inflammatory Response CCR10 Chemokine Receptor Binding Eosinophil Chemotaxis Cell Motility Eosinophil Migration CCR Chemokine Receptor Binding Positive Regulation Of Leukocyte Chemotaxis Mononuclear Cell Migration Cell Migration Killing Of Cells Of Another Organism Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration CXCR Chemokine Receptor Binding Cell Killing Immune Response Cytokine-mediated Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Regulation Of Chemotaxis Response To External Biotic Stimulus Cellular Response To Lipid Defense Response Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Mononuclear Cell Migration CCL19-activated CCR7 Signaling Pathway Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Cell Migration Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Motility Response To Lipopolysaccharide	Cytoplasmic Vesicle Vesicle-mediated Transport GTPase Activator Activity Regulation Of Long-term Neuronal Synaptic Plasticity Import Into Cell Endocytosis Endosomal Transport Small GTPase Binding Endosome Regulation Of Endocytosis Regulation Of Neuronal Synaptic Plasticity Early Endosome Intracellular Transport Intracellular Signaling Cassette Cellular Localization Glial Cell Development Establishment Of Localization In Cell Early Endosome Membrane Guanyl-nucleotide Exchange Factor Activity Presynapse Protein Tetramerization Regulation Of Cell Projection Assembly Schwann Cell Development Regulation Of Cilium Assembly Regulation Of Neurotransmitter Uptake Small GTPase-mediated Signal Transduction Cellular Response To Copper Ion Cellular Response To Growth Factor Stimulus Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Positive Regulation Of Protein Targeting To Membrane Amyloid Fibril Formation Regulation Of Vesicle-mediated Transport Regulation Of Cellular Component Organization Microglial Cell Activation Regulation Of Catalytic Activity Response To Growth Factor Recycling Endosome Regulation Of Protein Targeting To Membrane Leukocyte Activation Involved In Inflammatory Response Response To Copper Ion Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endocytosis Signal Transduction Glucagon-like Peptide 1 Receptor Activity Response To Desipramine
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