GPI and PARP14

Number of citations of the paper that reports this interaction (PubMedID 17875708)
0

Data Source:
HPRD (in vivo)

		GPI	PARP14
Description		glucose-6-phosphate isomerase	poly(ADP-ribose) polymerase family member 14
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Secretory Granule Lumen Ciliary Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Glucose-6-phosphate Isomerase Activity Cytokine Activity Protein Binding Growth Factor Activity Isomerase Activity Ubiquitin Protein Ligase Binding Monosaccharide Binding Carbohydrate Derivative Binding	Transcription Corepressor Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Enzyme Binding NAD+ Binding NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	In Utero Embryonic Development Mesoderm Formation Positive Regulation Of Immunoglobulin Production Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Gluconeogenesis Glycolytic Process Humoral Immune Response Signal Transduction Hemostasis Learning Or Memory Positive Regulation Of Endothelial Cell Migration Response To Estradiol Response To Progesterone Response To Testosterone Erythrocyte Homeostasis Response To Immobilization Stress Response To Muscle Stretch Glucose Homeostasis Negative Regulation Of Apoptotic Process Response To Cadmium Ion Glucose 6-phosphate Metabolic Process Canonical Glycolysis Carbohydrate Derivative Metabolic Process	Immune System Process Negative Regulation Of Gene Expression Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Innate Immune Response Negative Regulation Of DNA-templated Transcription Negative Regulation Of Type II Interferon-mediated Signaling Pathway Protein Poly-ADP-ribosylation Positive Regulation Of Interleukin-4-mediated Signaling Pathway
Pathways		TP53 Regulates Metabolic Genes Neutrophil degranulation Glycolysis Gluconeogenesis	Nicotinate metabolism Maturation of nucleoprotein Maturation of nucleoprotein
Drugs		alpha-D-glucose 6-phosphate 6-phospho-D-gluconic acid 5-phospho-D-arabinohydroxamic acid D-glucitol 6-phosphate 5-Phosphoarabinonic Acid Glucose-6-Phosphate D-erythrose 4-phosphate Fructose-6-phosphate Copper Artenimol
Diseases		Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean corpuscular volume ( 32888494)
Interacting Genes		7 interacting genes: AMFR CSNK2A1 DCC IGFBP3 LINC01554 PARP14 PCNA	4 interacting genes: FAM162A GPI NPHP3 PARP10
Entrez ID		2821	54625
HPRD ID		01394	11421
Ensembl ID		ENSG00000105220	ENSG00000173193
Uniprot IDs		A0A2U3TZU2 B4DE36 P06744	Q460N5 Q8N546
PDB IDs		1IAT 1IRI 1JIQ 1JLH 1NUH 6XUH 6XUI 8BBH 8P2K 9FCW 9FHF 9FKC 9FKF	3GOY 3Q6Z 3Q71 3SE2 3SMI 3SMJ 3VFQ 4ABK 4ABL 4D86 4F1L 4F1Q 4PY4 5LXP 5LYH 5NQE 5O2D 5QHT 5QHU 5QHV 5QHW 5QHX 5QHY 5QHZ 5QI0 5QI1 5QI2 5QI3 5QI4 5QI5 5QI6 5QI7 5QI8 5QI9 5QIA 5V7T 5V7W 6FYM 6FZM 6G0W 6WE2 6WE3 6WE4 7D2C 7L9Y 7LUN 7R3L
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Stress BAT3 Complex Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Growth Regulation Of Growth Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Metabolic Process Dorsal/ventral Axon Guidance Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Protein Phosphorylation Insulin-like Growth Factor Binding Protein Complex Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor Ternary Complex Negative Regulation Of Phosphorylation PCNA Complex Positive Regulation Of Deoxyribonuclease Activity PCNA-p21 Complex Replisome DNA Polymerase Processivity Factor Activity Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Leading Strand Elongation Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Positive Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Aggrephagy Anterior/posterior Axon Guidance Negative Regulation Of Dendrite Development MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Type II Interferon-mediated Signaling Pathway Derlin-1 Retrotranslocation Complex Insulin-like Growth Factor II Binding Regulation Of DNA Repair Positive Regulation Of DNA-directed DNA Polymerase Activity Regulation Of SREBP Signaling Pathway Wnt Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Cell Death Double-strand Break Repair Via Classical Nonhomologous End Joining Apoptotic Process Rhythmic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Programmed Cell Death Negative Regulation Of Collateral Sprouting	Nicotinamide Nucleotide Metabolic Process Glucose-6-phosphate Isomerase Activity Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Monosaccharide Binding Maintenance Of Animal Organ Identity Ureter Development Ciliary Inversin Compartment Determination Of Digestive Tract Left/right Asymmetry Determination Of Pancreatic Left/right Asymmetry Convergent Extension Involved In Gastrulation Determination Of Liver Left/right Asymmetry Negative Regulation Of Protein K63-linked Ubiquitination NAD+-protein-lysine ADP-ribosyltransferase Activity Fructose 6-phosphate Metabolic Process Carbohydrate Derivative Binding Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Erythrocyte Homeostasis Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Convergent Extension Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Atrial Septum Development Kidney Morphogenesis NAD+-protein-aspartate ADP-ribosyltransferase Activity Negative Regulation Of Protein Polyubiquitination Protein Auto-ADP-ribosylation NAD+ Biosynthetic Process Via The Salvage Pathway NAD+-protein-glutamate ADP-ribosyltransferase Activity Regulation Of Protein K63-linked Ubiquitination Glycolytic Process Through Glucose-6-phosphate Response To Immobilization Stress Nucleobase-containing Small Molecule Metabolic Process Nucleoside Phosphate Metabolic Process Response To Muscle Stretch Purine-containing Compound Metabolic Process Glucose 6-phosphate Metabolic Process Glycolytic Process Through Fructose-6-phosphate Glucose Catabolic Process Canonical Glycolysis Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Protein Polyubiquitination NAD+ Biosynthetic Process Viral Protein Processing Translesion Synthesis Pyridine Nucleotide Biosynthetic Process NAD+-protein Mono-ADP-ribosyltransferase Activity Protein Poly-ADP-ribosylation K63-linked Polyubiquitin Modification-dependent Protein Binding
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