GNRHR and RGS10

Number of citations of the paper that reports this interaction (PubMedID 12062898)
0

Data Source:
HPRD (in vivo)

		GNRHR	RGS10
Description		gonadotropin releasing hormone receptor	regulator of G protein signaling 10
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Body Synapse
	Molecular Function	G Protein-coupled Receptor Activity Gonadotropin-releasing Hormone Receptor Activity Protein-hormone Receptor Activity	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Gonadotropin Secretion Cellular Response To Hormone Stimulus Cellular Response To Gonadotropin-releasing Hormone	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Hormone ligand-binding receptors G alpha (q) signalling events	G alpha (i) signalling events G alpha (i) signalling events
Drugs		Leuprolide Goserelin Cetrorelix Abarelix Gonadorelin Nafarelin Danazol Teverelix Sufugolix Degarelix Buserelin Ganirelix Histrelin Triptorelin Gestrinone Relugolix Elagolix Linzagolix
Diseases		Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Regular attendance at a pub or social club ( 29970889)	Depressive symptoms (stressful life events interaction) ( 27529621) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Obstetric antiphospholipid syndrome ( 28424481)
Interacting Genes		5 interacting genes: GNRH1 GPAA1 RGS10 TMEM161A TSPAN7	10 interacting genes: ADRB2 APP CALM1 GNAI1 GNAI3 GNAO1 GNAZ GNRHR PLEKHF2 PRKACA
Entrez ID		2798	6001
HPRD ID		00732	04172
Ensembl ID		ENSG00000109163	ENSG00000148908
Uniprot IDs		P30968	O43665
PDB IDs		7BR3	2DLR 2I59 2IHB
Enriched GO Terms of Interacting Partners?		Response To Prolactin Negative Regulation Of Immature T Cell Proliferation Neurosecretory Vesicle Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane Gonadotropin-releasing Hormone Receptor Binding Gonadotropin Hormone-releasing Hormone Activity Regulation Of Ovarian Follicle Development GPI-anchor Transamidase Activity GPI-anchor Transamidase Complex Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis Protein Retention In ER Lumen GPI Anchor Binding Estrous Cycle Negative Regulation Of Neuron Migration	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding G Protein-coupled Serotonin Receptor Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of System Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Negative Regulation Of Peptide Secretion Regulation Of Protein Transport Regulation Of Peptide Hormone Secretion Modulation Of Chemical Synaptic Transmission Negative Regulation Of Protein Localization Regulation Of Transport Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Negative Regulation Of Hormone Secretion Regulation Of Biological Quality Regulation Of Muscle System Process Regulation Of Blood Circulation Negative Regulation Of Protein Secretion Regulation Of Hormone Secretion Regulation Of Protein Secretion Cell Body Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Calcium-mediated Signaling GTPase Activity Signal Transduction Regulation Of Metal Ion Transport Positive Regulation Of CAMP/PKA Signal Transduction GTP Binding Negative Regulation Of Protein Transport Plasma Membrane Neuronal Dense Core Vesicle Negative Regulation Of Cell Communication Cellular Response To Oxygen-containing Compound Regulation Of Monoatomic Ion Transport Negative Regulation Of Signaling Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Transport Negative Regulation Of Establishment Of Protein Localization Positive Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Secretion By Cell
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