GNAO1 and RGS14

Number of citations of the paper that reports this interaction (PubMedID 10926822)
53

Data Source:
HPRD (in vitro)

		GNAO1	RGS14
Description		G protein subunit alpha o1	regulator of G protein signaling 14
Image
GO Annotations	Cellular Component	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Presynaptic Membrane Cell Body Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Glutamatergic Synapse GABA-ergic Synapse	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Cytoskeleton Microtubule Plasma Membrane Postsynaptic Density Membrane Nuclear Body PML Body Dendrite Cell Projection Dendritic Spine Synapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Adenylate Cyclase Regulator Activity Hydrolase Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	G-protein Alpha-subunit Binding GTPase Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Microtubule Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity GTPase Regulator Activity GTPase Activating Protein Binding
	Biological Process	Vesicle Docking Involved In Exocytosis Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Locomotory Behavior Regulation Of Heart Contraction Negative Regulation Of Insulin Secretion Postsynaptic Modulation Of Chemical Synaptic Transmission	Mitotic Cell Cycle Nucleocytoplasmic Transport Response To Oxidative Stress Spindle Organization Chromosome Segregation Signal Transduction G Protein-coupled Receptor Signaling Pathway Learning Long-term Memory Regulation Of G Protein-coupled Receptor Signaling Pathway Visual Learning Negative Regulation Of Signal Transduction Zygote Asymmetric Cell Division Negative Regulation Of Synaptic Plasticity Negative Regulation Of MAP Kinase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Neurogenesis Modulation Of Chemical Synaptic Transmission Cell Division Long-term Synaptic Potentiation Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		Ca2+ pathway Ca2+ pathway	G alpha (i) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cardioembolic stroke (CCSp classification) ( 32047268) Chronotype ( 30696823) Daytime nap ( 33568662) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) HDL cholesterol levels ( 32203549) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)	Activated partial thromboplastin time ( 22703881) Allergic disease (asthma, hay fever or eczema) ( 29083406) Blood urea nitrogen levels ( 31152163) Calcium levels ( 24068962) Chronic kidney disease ( 20383146 31152163) Circulating fibroblast growth factor 23 levels ( 30217807) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244 21833088 24076602) Nephrolithiasis ( 22396660) Phosphorus levels ( 29403010) Red blood cell count ( 27863252 32888494) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Serum parathyroid hormone levels ( 27927781) Ulcerative colitis ( 28067908) Urolithiasis ( 30975718) Vitamin C levels ( 33203707) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		37 interacting genes: ADORA1 ADRA2A ADRA2C APLP2 CACNA1B CCR5 CDK2 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR ZBTB16	17 interacting genes: APP GNA11 GNAI1 GNAI2 GNAI3 GNAO1 NFKB1 POT1 PRKACA RAP1A RAP2A SORCS3 TINF2 TRAF2 VIPR2 WAS XPO1
Entrez ID		2775	10636
HPRD ID		00757	03944
Ensembl ID		ENSG00000087258	ENSG00000169220
Uniprot IDs		B3KP89 P09471 Q8N6I9	O43566
PDB IDs		6FUF 6G79 6K41 6OIK 6WWZ 7D76 7D77 7EJ0 7EJ8 7EJA 7EJK 7QVM 7T8X 7T90 7T94 7T96 7W2Z 7W6P 7W7E 7XJJ 7Y24 8DZQ 8E9X 8FN1 8HPT 8HQC 8I95 8I97 8I9L 8I9S 8IA2 8IEC 8IED 8IY9 8IYH 8IYW 8J6D 8JER 8JHN 8JZP 8JZZ 8TZQ 8U02 8XWV 8XX3 8XX6 8XX7 8XXH 8XXR 8XXX 8XXZ 8XYK 8Y0N 8YN7 8YN8 9F33 9F34	2JNU 2OM2 2XNS 3ONW 3QI2
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G-protein Alpha-subunit Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Plasma Membrane Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway GTPase Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Secretion By Cell Regulation Of Signaling GTPase Activator Activity Negative Regulation Of Secretion Negative Regulation Of Epinephrine Secretion Negative Regulation Of Transport Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion Regulation Of Amine Transport Regulation Of Hormone Secretion G Protein-coupled Peptide Receptor Activity Negative Regulation Of Insulin Secretion Negative Regulation Of Catecholamine Secretion Membrane Regulation Of Secretion By Cell Negative Regulation Of Peptide Secretion Negative Regulation Of Amino Acid Transport GDP-dissociation Inhibitor Activity Regulation Of Secretion G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Protein Transport Negative Regulation Of Establishment Of Protein Localization G Protein-coupled Acetylcholine Receptor Signaling Pathway Alpha2-adrenergic Receptor Activity Response To Alcohol Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Regulation Of Biological Quality Positive Regulation Of GTPase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signaling Positive Regulation Of ERBB Signaling Pathway Dendrite Regulation Of Signal Transduction Cell Communication Regulation Of MAPK Cascade Regulation Of Peptide Hormone Secretion Negative Regulation Of Norepinephrine Secretion	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein Activity G Protein-coupled Receptor Binding GTPase Activity G Protein-coupled Receptor Signaling Pathway GTP Binding Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway GDP Binding Signal Transduction G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Protein Transport G Protein-coupled Serotonin Receptor Binding Postsynaptic Modulation Of Chemical Synaptic Transmission Modulation Of Chemical Synaptic Transmission Regulation Of Biological Quality Adenylate Cyclase Regulator Activity Telomere Assembly Regulation Of Transport Regulation Of Establishment Of Protein Localization Intracellular Signaling Cassette Cellular Response To Oxygen-containing Compound Regulation Of Secretion By Cell Negative Regulation Of Secretion By Cell Regulation Of Protein Localization Shelterin Complex Regulation Of Insulin Secretion Regulation Of Secretion Negative Regulation Of Secretion Regulation Of Cellular Component Organization Midbody Nuclear Telomere Cap Complex Synaptic Membrane Regulation Of Peptide Hormone Secretion Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Rap Protein Signal Transduction Telomere Capping Cell Body Regulation Of Steroid Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Forskolin Regulation Of Cell Junction Assembly Nucleotide Binding Regulation Of Hormone Secretion
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?