GNAI2 and P2RY12

Number of citations of the paper that reports this interaction (PubMedID 8554519)
26

Data Source:
HPRD (in vivo)

		GNAI2	P2RY12
Description		G protein subunit alpha i2	purinergic receptor P2Y12
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Dendrite Midbody Ciliary Basal Body Cell Body Extracellular Exosome Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle Extracellular Vesicle	Plasma Membrane Cell Surface Membrane Cell Projection Membrane Cell Body Membrane
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	G Protein-coupled Adenosine Receptor Activity G Protein-coupled ADP Receptor Activity G Protein-coupled Receptor Activity Guanyl-nucleotide Exchange Factor Activity G Protein-coupled Purinergic Nucleotide Receptor Activity
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Nutrient Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Urine Volume Negative Regulation Of Calcium Ion-dependent Exocytosis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway	G Protein-coupled Adenosine Receptor Signaling Pathway Monoatomic Ion Transport Substrate-dependent Cell Migration, Cell Extension Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Calcium-mediated Signaling Cerebral Cortex Radial Glia-guided Migration Cell Projection Organization Lamellipodium Assembly Platelet Activation Positive Regulation Of Integrin Activation By Cell Surface Receptor Linked Signal Transduction Positive Regulation Of Cell Adhesion Mediated By Integrin G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Monoatomic Ion Transport Response To Axon Injury Regulation Of Chemotaxis Positive Regulation Of Chemotaxis Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet Aggregation Cellular Response To ATP Visual System Development Positive Regulation Of Ruffle Assembly Regulation Of Microglial Cell Migration Positive Regulation Of Microglial Cell Migration
Pathways		Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	ADP signalling through P2Y purinoceptor 12 P2Y receptors G alpha (i) signalling events
Drugs			Ticlopidine Treprostinil Clopidogrel Promethazine Epoprostenol Regrelor Prasugrel Elinogrel Cangrelor Ticagrelor Selatogrel Vicagrel
Diseases		Adrenal carcinoma
GWAS		Body mass index ( 26426971) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from tea ( 33287642) Cortical surface area (MOSTest) ( 32665545) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Morning person ( 30696823) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Diverticular disease ( 30177863)
Interacting Genes		69 interacting genes: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR1 CCR5 CHRM1 CNR1 CRYAA CTNNB1 CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LAG3 LHB LHCGR LPAR3 LTB4R MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NLA NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PCP2 PLSCR1 PTEN PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TNFAIP3 TRIP6 TSHR TTC1 TUBA4A	1 interacting genes: GNAI2
Entrez ID		2771	64805
HPRD ID		00764	02743
Ensembl ID		ENSG00000114353	ENSG00000169313
Uniprot IDs		B3KP24 B3KX51 P04899	A8K7T1 Q9H244
PDB IDs		6D9H 7F8V 7LD3 7LD4 7WV9 7WVV 7WVW 7WVX 7WVY 7XXI 7YJ4 7YK6 7YK7 8K6M 8K6N 8K6O 8KGG 8THK 8THL 8Y45 8ZSJ 8ZSP 8ZSS 8ZSV	4NTJ 4PXZ 4PY0 7PP1 7XXI
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Alpha-subunit Binding Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Inflammatory Response Regulation Of Monoatomic Ion Transport Regulation Of Biological Quality Negative Regulation Of Signal Transduction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of MAPK Cascade Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway System Process Signaling Regulation Of Blood Circulation Cell Communication Positive Regulation Of Cell Communication Regulation Of Metal Ion Transport Positive Regulation Of MAPK Cascade Positive Regulation Of Signaling Nervous System Process Positive Regulation Of Monoatomic Ion Transport GTPase Regulator Activity Response To Stress Cell-cell Signaling Vascular Process In Circulatory System Negative Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Locomotion Regulation Of Smooth Muscle Contraction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Vasoconstriction Regulation Of System Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Blood Pressure Regulation Of Intracellular Signal Transduction	Purinergic Nucleotide Receptor Signaling Pathway Guanyl Nucleotide Binding Regulation Of Urine Volume Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Superoxide Anion Generation Positive Regulation Of Urine Volume G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Superoxide Anion Generation Neuronal Dense Core Vesicle G Protein-coupled Adenosine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Regulation Of Superoxide Metabolic Process Heterotrimeric G-protein Complex Negative Regulation Of Exocytosis Negative Regulation Of Synaptic Transmission Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Acetylcholine Receptor Signaling Pathway Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Signal Transduction Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process G Protein-coupled Receptor Binding Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Cell Body Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Extracellular Vesicle Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Neural Precursor Cell Proliferation Renal System Process Regulation Of Regulated Secretory Pathway Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Secretion By Cell Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Nutrient Negative Regulation Of Catalytic Activity Negative Regulation Of Secretion Regulation Of Exocytosis Midbody Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Calcium Ion Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
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