GNA12 and S1PR4

Number of citations of the paper that reports this interaction (PubMedID 12761884)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		GNA12	S1PR4
Description		G protein subunit alpha 12	sphingosine-1-phosphate receptor 4
Image
GO Annotations	Cellular Component	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Lateral Plasma Membrane Brush Border Membrane Neuron Projection Neuronal Cell Body	Cytoplasm Mitochondrion Plasma Membrane Membrane Presynapse
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding Protein Phosphatase 2A Binding Protein Phosphatase Activator Activity	G Protein-coupled Receptor Activity Protein Binding Lipid Binding Sphingosine-1-phosphate Receptor Activity
	Biological Process	In Utero Embryonic Development Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Blood Pressure Regulation Of Cell Shape Response To Xenobiotic Stimulus Regulation Of Fibroblast Migration Cell Differentiation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Embryonic Digit Morphogenesis Rho-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration	Sphingosine-1-phosphate Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Pathways		G alpha (12/13) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)	G alpha (i) signalling events Lysosphingolipid and LPA receptors
Drugs			Fingolimod
Diseases
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Daytime sleep phenotypes ( 27126917) Eosinophil count ( 32888494) Height ( 19343178 31562340 28552196 20189936 20881960 18391951 25282103 25429064) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Inflammatory bowel disease ( 28067908) Lateral ventricular volume in normal aging ( 30258056) Loneliness (linear analysis) ( 27629369) Medial thalamic nuclei volume ( 34006833) Monocyte count ( 27863252) Offspring birth weight ( 31043758) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252) Schizophrenia x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Subcortical volume (MOSTest) ( 32665545) Tonsillectomy ( 28928442 27182965) Ulcerative colitis ( 28067908 23128233 21297633) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412) Weight ( 28552196) White matter integrity ( 23218918)	Asthma ( 31959851) Basophil percentage of granulocytes ( 27863252) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252) Mean platelet volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 29403010 27863252)
Interacting Genes		30 interacting genes: ACTB AGTR1 AKAP13 APP ARAF ARHGEF11 ARHGEF12 BTK CDH1 CDH15 CDH2 DRD5 F2R GNA13 GNB1 HSP90AA1 IL3RA NAPA PPP2R1A PPP5C PRKCA PRKCB PRKCD PRKCE RASA2 S1PR4 S1PR5 TBXA2R TEC TSHR	5 interacting genes: GEMIN4 GNA12 GNA13 GNAI1 TNFSF14
Entrez ID		2768	8698
HPRD ID		05093	04779
Ensembl ID		ENSG00000146535	ENSG00000125910
Uniprot IDs		E9PC54 Q03113 Q6ZQV4	O95977
PDB IDs		7YDJ	2DCO
Enriched GO Terms of Interacting Partners?		Plasma Membrane G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signal Transduction Intracellular Signaling Cassette Intracellular Signal Transduction Membrane Regulation Of Intracellular Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Positive Regulation Of Transport Positive Regulation Of Protein Transport Regulation Of Cell Communication Regulation Of Signaling Cell-cell Junction Organization Regulation Of Protein Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Signal Transduction Regulation Of Protein Localization Adherens Junction Organization Cell-cell Junction Assembly Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Establishment Of Protein Localization Presynapse G Protein-coupled Receptor Activity Histone H3T6 Kinase Activity Cellular Response To Catecholamine Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process Rho Protein Signal Transduction Response To Catecholamine Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Regulation Of Transport Positive Regulation Of Signal Transduction G Protein-coupled Receptor Binding Positive Regulation Of Protein Localization Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Blood Pressure Cell Junction Organization Regulation Of MAPK Cascade Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Intracellular Signal Transduction Catenin Complex Extracellular Exosome Regulation Of Superoxide Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Response To Alkaloid	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding G Protein Activity Rho-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway T Cell Migration Regulation Of Fibroblast Migration GTPase Activity Brush Border Membrane GTP Binding Lymphocyte Migration Rho Protein Signal Transduction Mononuclear Cell Migration Regulation Of Cell Shape G Protein-coupled Receptor Signaling Pathway D2 Dopamine Receptor Binding Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Regulation Of Blood Pressure Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Regulation Of Cell Migration Leukocyte Migration Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Cell Motility Regulation Of Cell Morphogenesis In Utero Embryonic Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regulation Of Locomotion Small GTPase-mediated Signal Transduction Regulation Of Protein Localization To Cell Cortex Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway SMN Complex Gemini Of Cajal Bodies Cellular Response To Forskolin Regulation Of Relaxation Of Muscle T Cell Chemotaxis Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Positive Regulation Of Myoblast Fusion Small Nuclear Ribonucleoprotein Complex Response To Forskolin SMN-Sm Protein Complex
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