BMP10 and ACVR2A

Number of citations of the paper that reports this interaction (PubMedID 22718755)
36

Data Source:
BioGRID (pull down)

		BMP10	ACVR2A
Description		bone morphogenetic protein 10	activin A receptor type 2A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Z Disc	Cytoplasm Plasma Membrane Cell Surface Membrane Inhibin-betaglycan-ActRII Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Telethonin Binding Receptor Serine/threonine Kinase Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Activin Receptor Activity, Type I Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Identical Protein Binding Metal Ion Binding Activin Binding BMP Receptor Activity
	Biological Process	Kidney Development Cell Adhesion Heart Development Adult Heart Development Negative Regulation Of Endothelial Cell Migration Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Activin Receptor Signaling Pathway Sarcomere Organization Positive Regulation Of DNA-templated Transcription Positive Regulation Of Multicellular Organismal Process Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Heart Trabecula Formation Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis	Osteoblast Differentiation Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Male Gonad Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Negative Regulation Of Ossification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Sperm Ejaculation Penile Erection Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Development Sertoli Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus
Pathways		Signaling by BMP Molecules associated with elastic fibres	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGFBR3 regulates activin signaling
Drugs			Sotatercept
Diseases
GWAS		Chronic rhinosinusitis ( 33393196)	Adult body size ( 32376654) Adventurousness ( 30643258) Arterial stiffness index ( 31235810) Asthma (adult onset) ( 31036433) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Cerebrospinal T-tau levels ( 28247064) Diastolic blood pressure ( 30224653) Eosinophil count ( 32888494) Estimated glomerular filtration rate ( 31015462) Feeling hurt ( 29500382) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Feeling tense ( 29500382) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate (creatinine) ( 26831199) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) High myopia ( 31816047) Loneliness (MTAG) ( 29970889) Neutrophil percentage of granulocytes ( 27863252) Photic sneeze reflex ( 30899065) Refractive error ( 32231278) Response to statin therapy ( 20339536) Retinal detachment or retinal break ( 31816047) Urate levels ( 31985003 23263486) White blood cell count (basophil) ( 27863252)
Interacting Genes		67 interacting genes: ACVR2A ACVR2B AP4B1 APOA5 AQP6 ARL13B BIK BMPR2 BSCL2 BSND C2orf42 CCDC70 CD33 CISD2 CLDN7 CNRIP1 COQ9 CPLX4 CREB3L1 DEXI EBP ERP29 FAM209A FCGR1A FCRL4 FFAR2 FKBP7 FNDC9 GGT6 GJB1 GPR152 GPX8 HSD17B13 IL3RA JAGN1 KIR2DL3 KIR3DL1 KLRC1 LRRC25 LRRC4C MGST3 MRPS18B MS4A3 MTIF3 PLPP4 PNO1 RCN1 REEP4 SERINC3 SIT1 SLC10A1 SLC10A6 SLC35H1 SLC38A1 SLC4A1 SNRNP27 SPAG4 TCTA TMEM14B TMEM31 TMEM45B TMEM86B TMPRSS2 TNFSF14 TNFSF8 TSPAN31 VSIR	24 interacting genes: ACVRL1 BACE2 BMP10 BMP2 BMP4 BMP6 BMP7 CRIPTO DAXX DYNLT4 ENG ERBIN GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 NODAL PRSS50 SYNJ2BP TGFBR3
Entrez ID		27302	92
HPRD ID		09788	00025
Ensembl ID		ENSG00000163217	ENSG00000121989
Uniprot IDs		O95393	P27037
PDB IDs		6SF1 6SF3 7PPA 7PPB 7PPC 9DPY	3Q4T 3SOC 4ASX 5NH3 7U5P
Enriched GO Terms of Interacting Partners?		Membrane Activin Receptor Activity, Type II Protein Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Plasma Membrane Activin Receptor Activity Venous Blood Vessel Development Bile Acid:sodium Symporter Activity Positive Regulation Of Activin Receptor Signaling Pathway Activin Receptor Signaling Pathway Activin Receptor Complex Lymphatic Endothelial Cell Differentiation Fc-gamma Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway BMP Receptor Activity	Positive Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of SMAD Protein Signal Transduction Growth Factor Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Cytokine Activity Activin Receptor Signaling Pathway Positive Regulation Of Cartilage Development Cell Surface Receptor Signaling Pathway Cellular Response To BMP Stimulus Regulation Of Cartilage Development Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Heart Development Extracellular Space Cellular Response To Growth Factor Stimulus Signal Transduction Response To Growth Factor Positive Regulation Of Epithelial Cell Differentiation Regulation Of Intracellular Signal Transduction Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Animal Organ Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Development Negative Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Signal Transduction Regulation Of Cell Migration Epithelial To Mesenchymal Transition Regulation Of Epithelial Cell Differentiation BMP Receptor Binding Positive Regulation Of BMP Signaling Pathway Tissue Morphogenesis Enzyme Activator Complex Regulation Of Cell Motility Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Differentiation Regulation Of Locomotion Transforming Growth Factor Beta Receptor Signaling Pathway Cartilage Development Mesenchymal Cell Differentiation
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