PDCD4 and EIF4A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		PDCD4	EIF4A2
Description		programmed cell death 4	eukaryotic translation initiation factor 4A2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Apoptotic Process BMP Signaling Pathway Negative Regulation Of JUN Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of Inflammatory Response Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Cellular Response To Lipopolysaccharide Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Endothelial Cell Apoptotic Process	Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Negative Regulation Of RNA-dependent RNA Polymerase Activity Cellular Response To Leukemia Inhibitory Factor
Pathways		Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases
GWAS		Fish- and plant-related diet ( 32066663)
Interacting Genes		22 interacting genes: APOE BTRC CSNK2A1 EIF4A1 EIF4A2 EIF4A3 EIF4G1 FILNC1 IBTK LRRK1 LYN OGT PRMT5 PSEN1 PSEN2 RPL5 RPLP1 RPS13 RPS6KA1 SKP2 SUMO2 WDR77	25 interacting genes: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 FTCD GOLGA2 HSPB2 IPO11 LINC01554 MCPH1 MDFI NEK2 PDCD4 PFDN1 PIH1D2 RIPPLY3 SLC16A9 SSX2IP SUMO2 TK1 TRIM36 TRIM39 ZNF620
Entrez ID		27250	1974
HPRD ID		10549	03062
Ensembl ID		ENSG00000150593	ENSG00000156976
Uniprot IDs		B4DKX4 Q53EL6	Q14240
PDB IDs		2GGF 2KZT 2RG8 2ZU6 3EIJ 8XXL 8XXM 8XXN 9BKD 9BLN	3BOR
Enriched GO Terms of Interacting Partners?		Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Translation Regulation Of Primary Metabolic Process Regulation Of Proteolysis Positive Regulation Of Macromolecule Metabolic Process Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Translation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Amyloid Precursor Protein Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Translational Initiation Cytoplasmic Translational Initiation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Translation Ribonucleoprotein Complex Binding Negative Regulation Of Macromolecule Metabolic Process Aspartic Endopeptidase Activity, Intramembrane Cleaving Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Proteolysis Translation Initiation Factor Activity Gamma-secretase Complex Negative Regulation Of Metabolic Process Positive Regulation Of Translation Regulation Of Wnt Signaling Pathway Negative Regulation Of Gene Expression Notch Receptor Processing Glutamatergic Synapse Amyloid-beta Formation Epithelial Cell Proliferation TORC1 Signaling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction	Centrosome Cycle Regulation Of Cell Cycle Eukaryotic Translation Initiation Factor 4F Complex Microtubule Organizing Center Organization
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