CHMP2A and KERA

		CHMP2A	KERA
Description		charged multivesicular body protein 2A	keratocan
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Kinetochore Chromatin ESCRT III Complex Nucleus Nuclear Envelope Nuclear Pore Lysosomal Membrane Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Membrane Membrane Coat Midbody Late Endosome Membrane Multivesicular Body Membrane Extracellular Exosome Amphisome Membrane	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen
	Molecular Function	Protein Binding Protein Domain Specific Binding Phosphatidylcholine Binding
	Biological Process	Plasma Membrane Repair Autophagy Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Membrane Invagination Exit From Mitosis Regulation Of Centrosome Duplication Protein Transport Macroautophagy Viral Release From Host Cell Nuclear Membrane Reassembly Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Protein Localization Late Endosome To Vacuole Transport Viral Budding From Plasma Membrane Protein Polymerization Protein Homooligomerization Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport Positive Regulation Of Exosomal Secretion Negative Regulation Of Centriole Elongation ESCRT III Complex Disassembly	Visual Perception Cornea Development In Camera-type Eye
Pathways		Budding and maturation of HIV virion Macroautophagy Lysosome Vesicle Biogenesis Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Keratan sulfate biosynthesis Keratan sulfate degradation Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs
Diseases			Cornea plana congenita
GWAS		Mean corpuscular hemoglobin ( 32888494)	Pre-treatment viral load in HIV-1 infection ( 31219150) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure (alcohol consumption interaction) ( 24376456)
Interacting Genes		22 interacting genes: CHD3 CHMP3 CYP4F2 DOCK8 E2F4 EIF2B5 ITGA5 KERA MAPKAPK3 MITD1 NCOA1 NOL4 SLC25A1 SNCA STAMBP TGFB3 UFD1 USP54 USP8 VPS4A VPS4B ZNF32	2 interacting genes: CHMP2A UNG
Entrez ID		27243	11081
HPRD ID		12520	04477
Ensembl ID		ENSG00000130724	ENSG00000139330
Uniprot IDs		M0R1T5 O43633	O60938
PDB IDs		7ZCG 7ZCH
Enriched GO Terms of Interacting Partners?		Mitotic Cytokinetic Process Viral Budding Viral Budding Via Host ESCRT Complex Midbody Abscission Cytokinetic Process Multivesicular Body Sorting Pathway Viral Budding From Plasma Membrane K63-linked Deubiquitinase Activity Late Endosome To Lysosome Transport Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Late Endosomal Microautophagy Regulation Of Exosomal Secretion Midbody Endosome Organization Nuclear Membrane Reassembly Cytoskeleton-dependent Cytokinesis Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Organization Late Endosome To Vacuole Transport Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Mitotic Metaphase Chromosome Alignment Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Nuclear Membrane Organization Autophagosome Maturation Viral Process Late Endosome Membrane Positive Regulation Of Secretion Biological Process Involved In Interaction With Host Endosome To Lysosome Transport Metaphase Chromosome Alignment Membrane Assembly ESCRT III Complex Disassembly ESCRT Complex Disassembly Mitotic Cytokinesis ATPase Complex Regulation Of Exocytosis Regulation Of Secretion Chromosome Localization Positive Regulation Of Exocytosis Positive Regulation Of Exosomal Secretion Nuclear Pore Protein Domain Specific Binding Cysteine-type Deubiquitinase Activity Nucleus Organization Protein Deubiquitination	Somatic Hypermutation Of Immunoglobulin Genes Deoxyribose Phosphate Catabolic Process Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal Base-excision Repair, AP Site Formation Single Strand Break Repair Ribosomal Small Subunit Binding Uracil DNA N-glycosylase Activity Somatic Diversification Of Immunoglobulins Involved In Immune Response Somatic Diversification Of Immune Receptors Via Somatic Mutation Deoxyribonucleotide Catabolic Process Pyrimidine Deoxyribonucleotide Catabolic Process Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Depyrimidination DNA Modification Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Pyrimidine-containing Compound Catabolic Process Plasma Membrane Repair Mitotic Cytokinetic Process ESCRT III Complex Multivesicular Body Membrane Negative Regulation Of Centriole Elongation Viral Budding From Plasma Membrane Amphisome Membrane Late Endosome To Lysosome Transport Lysosomal Membrane Organization Vesicle Fusion With Vacuole Kinetochore Microtubule Viral Budding Regulation Of Exosomal Secretion ESCRT III Complex Disassembly Nuclear Membrane Reassembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Viral Release From Host Cell ESCRT Complex Disassembly Midbody Abscission Membrane Coat Multivesicular Body-lysosome Fusion Positive Regulation Of Exosomal Secretion Exit From Mitosis Phosphatidylcholine Binding Multivesicular Body Organization Multivesicular Body Assembly Regulation Of Spindle Assembly Somatic Recombination Of Immunoglobulin Gene Segments Base-excision Repair Late Endosome To Vacuole Transport Deoxyribonucleotide Metabolic Process
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