ARFIP1 and ARF5

Number of citations of the paper that reports this interaction (PubMedID 35844135)
78

Data Source:
BioGRID (pull down, proximity labelling technology)

		ARFIP1	ARF5
Description		ARF interacting protein 1	ARF GTPase 5
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Cytosol Membrane Trans-Golgi Network Membrane	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Phospholipid Binding Protein Domain Specific Binding Phosphatidylinositol-4-phosphate Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding
	Biological Process	Intracellular Protein Transport Intracellular Protein Localization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Protein Secretion Negative Regulation Of Retrograde Transport, Endosome To Golgi	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport
Pathways			COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean platelet volume ( 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Type 2 diabetes ( 23532257)
Interacting Genes		18 interacting genes: AFF1 ARF1 ARF3 ARF5 BSND CMTM5 DESI2 KRT27 KRT33B MAGEA6 RPRM SCAMP1 SFT2D1 SLC2A4 SMIM5 SMPD2 SYNGR3 TNFRSF10D	20 interacting genes: AASS ACY3 AP1B1 AP3B1 ARFIP1 ARFIP2 ASAP2 DANCR DENND1A DENND1B DTX3 ERBB2 GGA1 GORAB IKBKG MPHOSPH9 PALS2 PIP5K1A RAB11FIP3 SNCA
Entrez ID		27236	381
HPRD ID		09331	00055
Ensembl ID		ENSG00000164144	ENSG00000004059
Uniprot IDs		B4E273 P53367 Q8N8M9	A4D0Z3 P84085
PDB IDs			2B6H
Enriched GO Terms of Interacting Partners?			Cellular Localization Establishment Of Localization In Cell Localization Within Membrane Trans-Golgi Network Membrane Intracellular Protein Localization Golgi Apparatus Clathrin-coated Vesicle Membrane Protein Transport Vesicle-mediated Transport To The Plasma Membrane Vesicle-mediated Transport Intracellular Transport Establishment Of Protein Localization Cytosol Clathrin Adaptor Complex Endocytic Recycling Protein Localization To Cell Periphery Protein Domain Specific Binding Melanosome Assembly Endosomal Transport Establishment Of Vesicle Localization GTP-dependent Protein Binding Small GTPase Binding Intracellular Protein Transport Platelet Dense Granule Organization Protein Localization To Membrane Vesicle Localization Phospholipid Binding Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Early Endosome Phosphatidylinositol Phosphate Binding Membrane Coat Phosphatidylinositol-4-phosphate Binding Protein Localization To Cell Surface Regulation Of Actin Nucleation Synaptic Vesicle Transport Golgi To Plasma Membrane Protein Transport Melanosome Organization Pigment Granule Organization Cytoplasmic Vesicle Membrane Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Saccharopine Dehydrogenase (NADP+, L-lysine-forming) Activity Saccharopine Dehydrogenase Activity Saccharopine Dehydrogenase (NAD+, L-lysine-forming) Activity Saccharopine Dehydrogenase (NAD+, L-glutamate-forming) Activity Negative Regulation Of Retrograde Transport, Endosome To Golgi
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