GNMT and NUDT18

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GNMT	NUDT18
Description		glycine N-methyltransferase	nudix hydrolase 18
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytosol
	Molecular Function	Protein Binding Folic Acid Binding Methyltransferase Activity Glycine Binding Transferase Activity Glycine N-methyltransferase Activity Identical Protein Binding S-adenosyl-L-methionine Binding	Protein Binding Hydrolase Activity Nucleoside Diphosphate Phosphatase Activity 8-oxo-dGDP Phosphatase Activity 8-oxo-GDP Phosphatase Activity 8-hydroxy-dADP Phosphatase Activity Metal Ion Binding
	Biological Process	Glycogen Metabolic Process Regulation Of Gluconeogenesis Methionine Metabolic Process One-carbon Metabolic Process Methylation S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Protein Homotetramerization Sarcosine Metabolic Process	Nucleotide Metabolic Process DADP Catabolic Process DGDP Catabolic Process GDP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways		Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation Developmental Lineage of Pancreatic Acinar Cells
Drugs		Ademetionine Glycine S-adenosyl-L-homocysteine
Diseases		Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GWAS		Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576) LDL cholesterol levels ( 32203549) Plasma homocysteine levels (post-methionine load test) ( 24651765)
Interacting Genes		32 interacting genes: ADAMTSL4 ARR3 ARRB1 COX7B CTNS DRC12 FRG1 GABRQ GAGE2A HDAC7 HPRT1 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NLA NTAQ1 NUDT18 OTOS PLEKHF2 POT1 PRKACA RPSA SDCBP SNRNP200 SRD5A2 STT3B TERF1 TERF2 TERF2IP TINF2 TRIM35 ZNF337	34 interacting genes: APIP CAVIN2 COIL CUTC DCTD DHPS DUT EVI5L GLUL GNMT GSE1 HSD17B14 KCTD13 KCTD17 KHDRBS3 KRT15 KRTAP4-12 KXD1 NADK NAT9 NT5C2 PAICS PCBD1 PSME3 RAB3IL1 RABAC1 RAD54B RWDD1 TARBP2 TERF2IP TIFA TRAF2 TRIM37 ZBED1
Entrez ID		27232	79873
HPRD ID		05970	07992
Ensembl ID		ENSG00000124713	ENSG00000275074
Uniprot IDs		A0A0S2Z5F2 Q14749 V9HW60	Q6ZVK8
PDB IDs		1R74 2AZT	3GG6 4HVY
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Chromosome Organization Telomeric D-loop Disassembly Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Telomere Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Chromosome, Telomeric Region Regulation Of DNA Biosynthetic Process Telomere Assembly DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomerase Activity Protection From Non-homologous End Joining At Telomere Regulation Of Chromosome Organization Double-stranded Telomeric DNA Binding Positive Regulation Of DNA Metabolic Process G Protein-coupled Receptor Internalization Telomere Maintenance In Response To DNA Damage Positive Regulation Of Organelle Organization Grooming Behavior Chromosome Organization Nuclear Body Positive Regulation Of Cellular Component Organization Negative Regulation Of Interleukin-2 Production Protein Localization To Chromosome Striated Muscle Dense Body Guanine Phosphoribosyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Component Organization Interleukin-5 Receptor Complex	Identical Protein Binding DUMP Biosynthetic Process DTMP Biosynthetic Process Pyrimidine Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Metabolic Process Negative Regulation Of Defense Response To Virus By Host Protein Complex Oligomerization Protein Homooligomerization Pyrimidine Deoxyribonucleotide Biosynthetic Process Nucleoside Monophosphate Biosynthetic Process Deoxyribonucleotide Metabolic Process Cytosol Nucleoside Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Protein Binding Amino Acid Biosynthetic Process L-amino Acid Metabolic Process Small Molecule Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Methionine Metabolic Process Negative Regulation Of Defense Response To Virus Alpha-amino Acid Metabolic Process Protein-containing Complex Assembly IMP Metabolic Process Nucleotide Biosynthetic Process Purine Nucleobase Metabolic Process Protein Tetramerization Nucleobase-containing Small Molecule Metabolic Process Nucleotide Metabolic Process Purine Nucleoside Metabolic Process Pyrimidine Nucleotide Biosynthetic Process Deoxyhypusine Synthase Activity Deoxyribose Phosphate Catabolic Process Deoxyribonucleotide Catabolic Process DUTP Catabolic Process DUTP Diphosphatase Activity Amino Acid Metabolic Process Intracellular Ammonium Homeostasis Tumor Necrosis Factor Receptor Binding Regulation Of SiRNA Processing Protein-containing Complex Organization TORC2 Complex Disassembly Protein Autosumoylation Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity GMP Metabolic Process Phosphoribosylaminoimidazole Carboxylase Activity Nucleoside Phosphotransferase Activity GMP Catabolic Process To Guanine Tubulin N-terminal-methionine Acetyltransferase Activity
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