SERP1 and ACAD11

		SERP1	ACAD11
Description		stress associated endoplasmic reticulum protein 1	acyl-CoA dehydrogenase family member 11
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Ribosome Cytoplasmic Microtubule Membrane	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Peroxisome Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding	Acyl-CoA Dehydrogenase Activity Long-chain Fatty Acyl-CoA Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Very-long-chain Fatty Acyl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding Medium-chain Fatty Acyl-CoA Dehydrogenase Activity
	Biological Process	Skeletal System Development Glucose Metabolic Process Protein Glycosylation Response To Unfolded Protein Plasma Membrane Organization Post-embryonic Development Protein Transport Insulin Secretion Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Insulin Secretion Protein Modification Process Positive Regulation Of Translation Positive Regulation Of Organ Growth Muscle Organ Morphogenesis Positive Regulation Of Growth Hormone Secretion	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase
Pathways		XBP1(S) activates chaperone genes Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Mitochondrial Fatty Acid Beta-Oxidation
Drugs
Diseases
GWAS		Academic attainment (English) ( 33594131)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Hemoglobin levels ( 32327693) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Menarche (age at onset) ( 25231870) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		57 interacting genes: ACAD11 ALG3 APH1A APP AQP6 AQP8 BIK BSCL2 CANX CD74 CD79A CRB3 CYBRD1 EBP FAM174A FAM209A FAM210B FKBP7 FRMD3 GJB3 GJB5 GKN1 GPR37L1 GPX8 HSD17B13 IL3RA JAGN1 KCNF1 KIR3DL3 LHFPL5 LMNA MTIF3 PLPPR1 REEP4 SAR1A SCNN1A SCNN1G SEC11C SEC61A1 SEC61B SLC10A1 SLC10A6 SLC18A1 SLC22A1 SLC22A2 SLC35H1 SLC71A2 SSMEM1 STX1A STX2 STX4 TIMMDC1 TLCD4 TMEM14B TMEM52B TMEM79 TNFRSF9	7 interacting genes: APP CD2BP2 CPNE4 NEK11 SELENOT SERP1 UBC
Entrez ID		27230	84129
HPRD ID		18037	13352
Ensembl ID		ENSG00000120742	ENSG00000240303
Uniprot IDs		Q9Y6X1	Q709F0
PDB IDs			2WBI
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Norepinephrine Uptake Endoplasmic Reticulum Serotonin Uptake Norepinephrine Transport Monoamine Transmembrane Transporter Activity Amine Transport Catecholamine Uptake Dopamine Uptake Serotonin Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Protein Binding Neurotransmitter Transport Apical Plasma Membrane Mitochondrial Membrane Endoplasmic Reticulum Membrane Putrescine Transmembrane Transporter Activity Monoatomic Ion Transport Neurotransmitter Reuptake Dopamine Transport Sensory Perception Of Salty Taste Xenobiotic Transmembrane Transporter Activity Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Bile Acid:sodium Symporter Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Monoamine Transport Neurotransmitter Uptake Lumenal Side Of Endoplasmic Reticulum Membrane Basolateral Plasma Membrane External Side Of Plasma Membrane Cornified Envelope Assembly Monoatomic Cation Transport Xenobiotic Transport Across Blood-brain Barrier Sec61 Translocon Complex Import Into Cell Organic Cation Transport Organic Hydroxy Compound Transport Cellular Response To Aldosterone Sodium Channel Complex Toxin Transmembrane Transporter Activity	Positive Regulation Of Growth Hormone Secretion Regulation Of Growth Hormone Secretion Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Translation Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Localization To Extracellular Region Hormone Secretion Insulin Secretion Peptide Hormone Secretion Hormone Transport Establishment Of Protein Localization To Extracellular Region Protein Secretion Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Peptide Transport Peptide Secretion Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Post-transcriptional Regulation Of Gene Expression Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Amide Transport Positive Regulation Of Hormone Secretion Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Cellular Response To Metal Ion Signal Release Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway
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