CHIA and TBC1D5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CHIA	TBC1D5
Description		chitinase acidic	TBC1 domain family member 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Cytoplasm Endosome Autophagosome Golgi Apparatus Cytosol Endosome Membrane Membrane AP-2 Adaptor Complex Retromer Complex Cytoplasmic Vesicle Atg1/ULK1 Kinase Complex
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Chitinase Activity Protein Binding Chitin Binding Endochitinase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Kinase Binding	GTPase Activator Activity Protein Binding AP-2 Adaptor Complex Binding Protein-containing Complex Binding Retromer Complex Binding
	Biological Process	Polysaccharide Catabolic Process Immune System Process Production Of Molecular Mediator Involved In Inflammatory Response Carbohydrate Metabolic Process Chitin Metabolic Process Chitin Catabolic Process Apoptotic Process Inflammatory Response Positive Regulation Of Chemokine Production Polysaccharide Digestion	Positive Regulation Of Receptor Internalization Autophagy Protein Transport Macroautophagy Retrograde Transport, Endosome To Golgi Response To Starvation Regulation Of Cilium Assembly
Pathways		Digestion of dietary carbohydrate
Drugs
Diseases
GWAS		Anti-Toxoplasma gondii IgG seropositivity ( 30610941) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Metabolite levels ( 23823483)	Age at first sexual intercourse ( 34211149) Aspartate aminotransferase levels ( 33547301) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Language functional connectivity ( 34929384) Mean platelet volume ( 32888494 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Parkinson's disease ( 32201043) Platelet count ( 32888494 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252 32888494) Schizophrenia ( 29483656 28991256 25056061) Self-reported risk-taking behaviour ( 30271922) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		3 interacting genes: COX20 RBBP8NL TBC1D5	11 interacting genes: AP2M1 ATXN1 CHIA EIF1AD FBXL7 GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B UBC ZBTB25
Entrez ID		27159	9779
HPRD ID		09355	10262
Ensembl ID		ENSG00000134216	ENSG00000131374
Uniprot IDs		A8K3T7 Q1M0P3 Q1M0P4 Q2VT96 Q9BZP6	B9A6K1 Q92609
PDB IDs		2YBT 2YBU 3FXY 3FY1 3RM4 3RM8 3RM9 3RME	5GTU
Enriched GO Terms of Interacting Partners?		AP-2 Adaptor Complex Retromer Complex Binding AP-2 Adaptor Complex Binding Atg1/ULK1 Kinase Complex Retromer Complex Mitochondrial Cytochrome C Oxidase Assembly Respiratory Chain Complex IV Assembly Positive Regulation Of Receptor Internalization	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Maturation Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Autophagosome Organization Ubiquitin Protein Ligase Binding Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Autophagy Catabolic Process GABA Receptor Binding Cytoplasmic Vesicle Polysaccharide Catabolic Process Response To Nutrient Levels Beta-tubulin Binding Organelle Membrane Microtubule Binding Organelle Assembly Cytosol Polysaccharide Metabolic Process Endocytic Vesicle Membrane Protein-containing Complex Organization Microtubule Endochitinase Activity Signal Sequence Binding POZ Domain Binding Carbohydrate Catabolic Process Polysaccharide Digestion Cellular Response To Oxygen-glucose Deprivation Extrinsic Component Of Presynaptic Endocytic Zone Membrane Macromolecule Catabolic Process Chitin Metabolic Process Chitin Catabolic Process Chitinase Activity Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Recycling Chitin Binding Response To Iron(II) Ion Postsynaptic Neurotransmitter Receptor Internalization Poly(G) Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
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