CPAMD8 and ADCYAP1

Number of citations of the paper that reports this interaction (PubMedID 1335692)
0

Data Source:
BioGRID (unspecified method)

		CPAMD8	ADCYAP1
Description		C3 and PZP like alpha-2-macroglobulin domain containing 8	adenylate cyclase activating polypeptide 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane	Extracellular Region Extracellular Space Neuron Projection Perikaryon
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Pituitary Adenylate Cyclase Activating Polypeptide Activity Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Peptide Hormone Receptor Binding
	Biological Process	Eye Development	Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Nervous System Development Female Pregnancy Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Insulin Secretion Neuron Projection Development Regulation Of Protein Localization Positive Regulation Of GTPase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Growth Hormone Secretion Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of CAMP/PKA Signal Transduction
Pathways			NGF-independant TRKA activation G alpha (s) signalling events Glucagon-type ligand receptors
Drugs			2,6-Diamino-Hexanoic Acid Amide
Diseases
GWAS		Brain lesion load ( 19010793) Cataracts ( 34127677) Crohn's disease ( 22412388) Height ( 28552196) Retinal detachment or retinal break ( 31816047)	Body size at age 10 ( 32376654) Chronotype ( 30696823) Midgestational cytokine/chemokine levels (fetal genetic effect) ( 30134952) Obesity-related traits ( 23251661) Pancreas volume ( 34128465) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659)
Interacting Genes		3 interacting genes: ADCYAP1 DPP4 SCTR	9 interacting genes: ADCYAP1R1 CASP2 CFTR CPAMD8 MME SCTR SHH VIPR1 VIPR2
Entrez ID		27151	116
HPRD ID		09892	02369
Ensembl ID		ENSG00000160111	ENSG00000141433
Uniprot IDs		A0A494C0S9 Q8IZJ3	B7Z222 P18509
PDB IDs			1GEA 2D2P 2JOD 6LPB 6M1I 6P9Y 6VN7 7VQX 7WBJ 8E3X 8E3Y
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Pituitary Adenylate Cyclase Activating Polypeptide Activity Glucagon Processing Secretin Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Signaling Receptor Binding Peptide Hormone Receptor Binding Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Growth Hormone Secretion Intercellular Canaliculus Negative Regulation Of Extracellular Matrix Disassembly Adhesion Of Symbiont To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Neutrophil Migration Regulation Of Cell-cell Adhesion Mediated By Integrin Negative Regulation Of Neutrophil Chemotaxis Dipeptidyl-peptidase Activity Psychomotor Behavior Virion Attachment To Host Cell Diet Induced Thermogenesis Intracellular Water Homeostasis Regulation Of Growth Hormone Secretion Activation Of Adenylate Cyclase Activity Adhesion Of Symbiont To Host Endocytosis Involved In Viral Entry Into Host Cell Locomotory Exploration Behavior Regulation Of Hormone Levels Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Regulation Of Biological Quality Positive Regulation Of Cyclase Activity Negative Regulation Of Extracellular Matrix Organization Lamellipodium Membrane Negative Regulation Of Leukocyte Chemotaxis Regulation Of Extracellular Matrix Disassembly Chemorepellent Activity Adaptive Thermogenesis Regulation Of Appetite Motor Behavior Neuropeptide Hormone Activity Aminopeptidase Activity Regulation Of Neutrophil Chemotaxis G Protein-coupled Receptor Signaling Pathway Behavioral Fear Response Exploration Behavior Behavioral Defense Response	Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity Peptide Hormone Binding G Protein-coupled Peptide Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Transmembrane Signaling Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Protein Processing Cell Surface Receptor Signaling Pathway Plasma Membrane Negative Regulation Of Response To Reactive Oxygen Species G Protein-coupled Receptor Signaling Pathway Cell Surface Protein Maturation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Neuropeptide Processing Secretin Receptor Activity Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Left Lung Development Positive Regulation Of Sclerotome Development Right Lung Development Polarity Specification Of Anterior/posterior Axis Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Primary Prostatic Bud Elongation Tracheoesophageal Septum Formation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Odontogenesis Of Dentin-containing Tooth Developmental Process Involved In Reproduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Anion Channel Activity Endopeptidase Activity Oligopeptidase Activity Creatinine Metabolic Process Intein-mediated Protein Splicing Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Peptidase Activity Endopeptidase Complex Odontogenesis Positive Regulation Of Monoatomic Anion Transport Lung Development Substance P Catabolic Process Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development
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