ZBTB11 and DSCR4

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		ZBTB11	DSCR4
Description		zinc finger and BTB domain containing 11	Down syndrome critical region 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Cellular_component
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding	Molecular_function
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Biological_process
Pathways
Drugs
Diseases
GWAS		Height ( 31562340)	Clostridioides difficle infection ( 33841421) Hip circumference adjusted for BMI ( 34021172) Idiopathic downbeat nystagmus ( 32157568) Metabolite levels ( 23823483) Rosacea symptom severity ( 29771307) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: DSCR4 DYRK1A PPP1CA SMAD7	6 interacting genes: KIF1B PRKAR1A USP2 VPS26C XRCC6 ZBTB11
Entrez ID		27107	10281
HPRD ID		15690	05318
Ensembl ID		ENSG00000066422	ENSG00000184029
Uniprot IDs		O95625 Q59H97
PDB IDs
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Via Nonhomologous End Joining Histone H3T45 Kinase Activity Beta-catenin Destruction Complex Disassembly Positive Regulation Of Chondrocyte Hypertrophy Double-strand Break Repair Rhythmic Process Negative Regulation Of Heterochromatin Formation Circadian Rhythm Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Activin Receptor Binding Tube Morphogenesis Adherens Junction Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Positive Regulation Of Chondrocyte Development Heteromeric SMAD Protein Complex Protein Stabilization Negative Regulation Of Chondrocyte Proliferation Regulation Of Chondrocyte Development RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Positive Regulation Of Termination Of RNA Polymerase II Transcription PTW/PP1 Phosphatase Complex RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Negative Regulation Of RNA Metabolic Process Regulation Of Heterochromatin Formation Double-strand Break Repair Via Alternative Nonhomologous End Joining RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Neurofilament Regulation Of Protein Metabolic Process Negative Regulation Of T Cell Cytokine Production Type I Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Stability Negative Regulation Of Microtubule Polymerization Negative Regulation Of Transcription By Competitive Promoter Binding Tissue Morphogenesis Telomere Maintenance In Response To DNA Damage Protein Phosphatase Type 1 Complex Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Adherens Junction Assembly Negative Regulation Of T-helper 17 Cell Differentiation I-SMAD Binding Negative Regulation Of Activin Receptor Signaling Pathway	Cyclin Binding
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