UQCRQ and JADE2

		UQCRQ	JADE2
Description		ubiquinol-cytochrome c reductase complex III subunit VII	jade family PHD finger 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III	Histone Acetyltransferase Complex Nucleoplasm Extracellular Exosome
	Molecular Function		Protein Binding Zinc Ion Binding Transferase Activity Histone H3K14 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Subthalamus Development Pons Development Cerebellar Purkinje Cell Layer Development Hippocampus Development Thalamus Development Hypothalamus Development Pyramidal Neuron Development Midbrain Development Cellular Respiration	Regulation Of Cell Growth Regulation Of DNA Replication Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Regulation Of Cell Cycle Regulation Of DNA Biosynthetic Process
Pathways		Respiratory electron transport Mitochondrial protein degradation Complex III assembly Complex III assembly	HATs acetylate histones
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Asthma ( 31619474)	Adult body size ( 32376654) Age at first birth ( 34211149 27798627) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) Coffee consumption ( 31046077) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hand grip strength ( 29691431) Household income (MTAG) ( 31844048) Mental health study participation (completed survey) ( 31263887) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Platelet distribution width ( 27863252) Smoking cessation ( 33082346) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 28869590) White blood cell count ( 32888494)
Interacting Genes		6 interacting genes: ERCC6 ERCC8 JADE2 OPTN POLR2M UBC	27 interacting genes: C5orf15 CBX8 CDCA7L CSNK2A1 DDX46 FBXO7 FSTL4 GAS2L2 GORASP2 H3-4 ING4 IRAK1 KLK2 PACSIN1 RAPGEF6 SAR1B SASH1 SH2B2 SMAD5-AS1 TCF7 TTC3 UQCRQ ZBTB3 ZBTB5 ZCCHC10 ZNF417 ZNF496
Entrez ID		27089	23338
HPRD ID		17941	15124
Ensembl ID		ENSG00000164405	ENSG00000043143
Uniprot IDs		O14949	A0A087X085 A0A0C4DFT8 B3KPL2 B4DFY8 G3XAA4 Q9NQC1
PDB IDs		5XTE 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Transcription-coupled Nucleotide-excision Repair Protein Ubiquitination Response To X-ray Protein Modification By Small Protein Conjugation Post-translational Protein Modification Site Of DNA Damage Nucleotide-excision Repair DNA-templated Transcription Elongation Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription-coupled Nucleotide-excision Repair Maintenance Of ER Location Regulation Of DNA Metabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Protein Modification Process Positive Regulation Of DNA Repair Response To Ionizing Radiation Response To UV Negative Regulation Of Receptor Recycling Type 2 Mitophagy Double-strand Break Repair Nucleotide-excision Repair Complex Regulation Of DNA Repair B-WICH Complex DNA Protection Transcription Elongation By RNA Polymerase I Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Response To Superoxide Response To Oxygen Radical Positive Regulation Of Xenophagy Histone H4K16 Acetyltransferase Activity Endoplasmic Reticulum Localization Transcription Elongation Factor Activity Nucleoplasm Pyrimidine Dimer Repair Golgi Ribbon Formation Histone H3K14 Acetyltransferase Activity Positive Regulation Of DNA Metabolic Process Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Transcription Preinitiation Complex Cul4A-RING E3 Ubiquitin Ligase Complex Response To Light Stimulus Protein Tag Activity Protein Tyrosine Kinase Activator Activity Response To Oxidative Stress Positive Regulation Of Transcription By RNA Polymerase III ATP-dependent DNA Damage Sensor Activity
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