LYPD3 and ATP1A3

		LYPD3	ATP1A3
Description		LY6/PLAUR domain containing 3	ATPase Na+/K+ transporting subunit alpha 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Side Of Membrane	Photoreceptor Inner Segment Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Membrane Axon Organelle Membrane Neuronal Cell Body Membrane Neuronal Cell Body Synapse Photoreceptor Inner Segment Membrane Neuron To Neuron Synapse Extracellular Vesicle
	Molecular Function	Laminin Binding	Nucleotide Binding Amyloid-beta Binding P-type Sodium:potassium-exchanging Transporter Activity Protein Binding ATP Binding P-type Potassium Transmembrane Transporter Activity ATP Hydrolysis Activity Metal Ion Binding Protein-folding Chaperone Binding Steroid Hormone Binding
	Biological Process	Cell-matrix Adhesion Negative Regulation Of Smooth Muscle Cell Apoptotic Process	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Intracellular Monoatomic Cation Homeostasis Intracellular Potassium Ion Homeostasis Sodium Ion Export Across Plasma Membrane Regulation Of Resting Membrane Potential Cellular Response To Steroid Hormone Stimulus Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Cellular Response To Amyloid-beta Neuron Projection Maintenance Potassium Ion Import Across Plasma Membrane
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs			Ouabain Bisacodyl Tegoprazan
Diseases			Primary torsion dystonia (PTD)
GWAS		Cotinine glucuronidation ( 25293881)	Brain morphology (MOSTest) ( 32665545) Meat-related diet ( 32066663)
Interacting Genes		18 interacting genes: AGR2 AGR3 ATP1A3 AURKA BAG4 BRMS1 CASP8 CHEK2 CTRB1 ERBB2 IGF1R LSP1 PALB2 PPM1D PTPRJ RB1CC1 SMAD4 STK11	11 interacting genes: ABCA4 ASH2L ATRX ATXN1 CASP8 DUSP4 LYPD3 PPFIA3 PRKD2 TRIM29 ZNF229
Entrez ID		27076	478
HPRD ID		10783	01666
Ensembl ID		ENSG00000124466	ENSG00000105409
Uniprot IDs		B2RBR3 O95274	M0R116 P13637 Q53ES0
PDB IDs		6IOM 6ION	8D3U 8D3V 8D3W 8D3X 8D3Y
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cell Projection Organization Protein Autophosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Glycoside Plasma Membrane Bounded Cell Projection Organization Apoptotic Process Negative Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Protein Phosphorylation G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Anoikis Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Programmed Cell Death Cell Cycle G2/M Phase Transition Phosphorylation Negative Regulation Of Signal Transduction Dystroglycan Binding Carbohydrate Homeostasis Glucose Homeostasis Response To Stress Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Cell Population Proliferation Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Component Organization Negative Regulation Of Intracellular Signal Transduction Protein Dephosphorylation Autophagosome Assembly Protein Kinase Activity Heart Development Positive Regulation Of Metabolic Process Autophagosome Organization Signal Transduction By P53 Class Mediator Negative Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway Ubiquitin Protein Ligase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Mitogen-activated Protein Kinase Binding Regulation Of Signal Transduction By P53 Class Mediator Phosphate-containing Compound Metabolic Process Regulation Of Growth
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