DAPP1 and MGARP

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		DAPP1	MGARP
Description		dual adaptor of phosphotyrosine and 3-phosphoinositides 1	mitochondria localized glutamic acid rich protein
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Membrane Axon Cytoplasm
	Molecular Function	Protein Binding Phospholipid Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding	Protein Binding
	Biological Process	Protein Dephosphorylation Signal Transduction	Protein Targeting To Mitochondrion Anterograde Axonal Transport Retrograde Axonal Transport Regulation Of Mitochondrion Organization Axonal Transport Of Mitochondrion Cerebral Cortex Development Axon Development Cellular Response To Steroid Hormone Stimulus Cellular Response To Hypoxia Cellular Response To Gonadotropin-releasing Hormone Negative Regulation Of Dendrite Development
Pathways		Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS		Red cell distribution width ( 32888494) Stroke ( 32693751)	Central corneal thickness ( 32528159)
Interacting Genes		23 interacting genes: BTK CNDP2 ERBB3 FAIM FCHSD2 FXN GSTCD HSD3B7 HSPA1A LCK LYN MAP4K1 MGARP MYLIP PLAGL2 PLCG1 PLCG2 RBP7 RPL23 SRC TM4SF19 TNFAIP1 ZNHIT1	3 interacting genes: DAPP1 EGFR TRIM54
Entrez ID		27071	84709
HPRD ID		05773	17805
Ensembl ID		ENSG00000070190	ENSG00000137463
Uniprot IDs		J3KNB3 Q9UN19	Q8TDB4
PDB IDs		1FAO 1FB8
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Phospholipase Activator Activity Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Regulation Of Programmed Cell Death Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phospholipase Binding Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process Positive Regulation Of Protein-containing Complex Assembly Response To Lipid Immune Response-activating Signaling Pathway Membrane Raft Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Fc-gamma Receptor Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Histamine Secretion By Mast Cell Positive Regulation Of Immune Response Protein Autophosphorylation Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of MAPK Cascade Cellular Response To Lipid Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Developmental Process T Cell Costimulation Positive Regulation Of Immune System Process Histamine Secretion Positive Regulation Of Epithelial Cell Migration Protein Kinase Activity Positive Regulation Of Innate Immune Response Signaling Receptor Activator Activity Release Of Sequestered Calcium Ion Into Cytosol Histamine Transport Negative Regulation Of Sequestering Of Calcium Ion	Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Multivesicular Body, Internal Vesicle Lumen Epidermal Growth Factor Binding
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