NPTN and SURF2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		NPTN	SURF2
Description		neuroplastin	surfeit 2
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Plasma Membrane Cell Surface Postsynaptic Density Membrane Axon Dendrite Presynaptic Membrane Synapse	Nucleoplasm Nucleolus Plasma Membrane Nuclear Speck
	Molecular Function	Type 1 Fibroblast Growth Factor Receptor Binding Protein Binding Cell Adhesion Molecule Binding Cell-cell Adhesion Mediator Activity	Protein Binding
	Biological Process	Negative Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Intracellular Calcium Ion Homeostasis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Long-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Synapse Organization Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Long-term Synaptic Potentiation Dendrite Self-avoidance Regulation Of Receptor Localization To Synapse Excitatory Synapse Assembly
Pathways		GABA receptor activation
Drugs
Diseases
GWAS		Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe ocular complications ( 28100913) Tourette syndrome ( 30818990) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Activated partial thromboplastin time ( 22703881) Malaria ( 31844061)
Interacting Genes		4 interacting genes: AATF AGTR1 SURF2 UBC	6 interacting genes: APP B4GALT3 NPTN PLAUR PRNP ZNF331
Entrez ID		27020	6835
HPRD ID		18033	15948
Ensembl ID		ENSG00000156642	ENSG00000148291
Uniprot IDs		Q9Y639	Q15527
PDB IDs		6A69
Enriched GO Terms of Interacting Partners?		Angiotensin Type I Receptor Activity Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Renal Sodium Excretion Embryonic Cleavage Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Leucine Zipper Domain Binding Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Macrophage Derived Foam Cell Differentiation Angiotensin-activated Signaling Pathway Low-density Lipoprotein Particle Remodeling Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Protein Tag Activity Negative Regulation Of Glycoprotein Metabolic Process Negative Regulation Of Glycoprotein Biosynthetic Process Regulation Of Amyloid Precursor Protein Biosynthetic Process Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Cholesterol Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation	Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Intracellular Copper Ion Homeostasis Copper Ion Homeostasis Extrinsic Component Of Membrane Cell Surface Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Molecular Function Activator Activity Cellular Response To Copper Ion Response To Copper Ion Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Phosphate Metabolic Process Neuron Recognition Regulation Of Amyloid Precursor Protein Catabolic Process Cellular Response To Amyloid-beta Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Calcium-mediated Signaling External Side Of Plasma Membrane Regulation Of Protein Processing Response To Amyloid-beta Regulation Of Protein Maturation Regulation Of Proteolysis Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Neuron Apoptotic Process Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Urokinase Plasminogen Activator Receptor Activity Type 8 Metabotropic Glutamate Receptor Binding Dendrite Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Modulation Of Chemical Synaptic Transmission Regulation Of Calcium-mediated Signaling Protein-folding Chaperone Binding Intracellular Chemical Homeostasis Acetylcholine Receptor Activator Activity Regulation Of Phosphorus Metabolic Process Regulation Of Type II Interferon Production Lipoprotein Particle Positive Regulation Of Protein Import Urokinase Plasminogen Activator Signaling Pathway Memory
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