BEX3 and MIF

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		BEX3	MIF
Description		brain expressed X-linked 3	macrophage migration inhibitory factor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Surface Vesicle Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Signaling Receptor Binding Death Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Metal Ion Binding Molecular Function Inhibitor Activity	Protease Binding Dopachrome Isomerase Activity Cytokine Activity Cytokine Receptor Binding Protein Binding Isomerase Activity Chemoattractant Activity Identical Protein Binding Phenylpyruvate Tautomerase Activity
	Biological Process	Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Ubiquitination	Prostaglandin Biosynthetic Process Positive Regulation Of Cytokine Production Immune System Process Negative Regulation Of Mature B Cell Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Macrophage Chemotaxis Carboxylic Acid Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Innate Immune Response Positive Regulation Of Fibroblast Proliferation Positive Chemotaxis Negative Regulation Of Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Involved In Immune Response Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Protein Homotrimerization Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cellular Response To Stress Positive Regulation Of Arachidonate Secretion Cellular Senescence Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Cellular Senescence
Pathways		NADE modulates death signalling	Cell surface interactions at the vascular wall Neutrophil degranulation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			3,4-Dihydroxycinnamic Acid 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester 4-Hydroxyphenylpyruvic acid 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Macrophage Migration Inhibitory Factor levels ( 27989323) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		44 interacting genes: AIMP2 AKAP8L BFSP2 CACYBP CBY2 CCDC116 CCDC85B CTNNBL1 DIABLO DSCR9 EMILIN1 ENKD1 FSD2 FTCD GOLGA8EP GOLGA8F ING4 ING5 KRT34 MCCD1 MDFI MIF MNAT1 NECAB2 NGFR NTRK3 PTPN13 S100A1 S100Z SIVA1 SMARCD1 SMPD1 TACC3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TSNAX USHBP1 VTA1 YWHAE ZNF417	17 interacting genes: BEX3 BNIPL CD74 CEBPA COPS5 COPS6 EGFR EXOSC7 FCER1G GNAL GORASP2 NME1 NTAQ1 STRN4 TP53 UPF2 ZNF408
Entrez ID		27018	4282
HPRD ID		02291	01091
Ensembl ID		ENSG00000166681	ENSG00000240972
Uniprot IDs		Q00994	I4AY87 P14174
PDB IDs			1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V 3SMB 3SMC 3U18 3WNR 3WNS 3WNT 4ETG 4EUI 4EVG 4F2K 4GRN 4GRO 4GRP 4GRQ 4GRR 4GRU 4GUM 4K9G 4OSF 4OYQ 4P01 4P0H 4PKK 4PKZ 4PLU 4TRF 4TRU 4WR8 4WRB 4XX7 4XX8 4Z15 4Z1T 4Z1U 5B4O 5BS9 5BSC 5BSI 5BSJ 5EIZ 5HVS 5HVT 5HVV 5J7P 5J7Q 5UMJ 5UMK 5UZY 5V70 5V73 5XEJ 6B1C 6B1K 6B2C 6BG6 6BG7 6CB5 6CBF 6CBG 6CBH 6FVE 6FVH 6OY8 6OYB 6OYE 6OYG 6PEG 7E45 7E47 7E49 7E4A 7E4B 7E4C 7KQX 7XTX 7XVX 8CA0 8IMR 8SON 8SPN 8TT9 9BNQ 9BNR
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Signaling Adaptor Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Programmed Cell Death CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cytoplasmic Side Of Plasma Membrane Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction A2A Adenosine Receptor Binding DNA Replication-dependent Chromatin Disassembly Regulation Of MAPK Cascade Neurotrophin Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Apoptotic Process Identical Protein Binding Cell Death Programmed Cell Death Regulation Of DNA-binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Negative Regulation Of Macrophage Migration S100 Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Cytoplasm Zinc Ion Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Immune Response Histone H3K4me3 Reader Activity Regulation Of Macromolecule Metabolic Process	Macrophage Migration Inhibitory Factor Binding Identical Protein Binding T Cell Activation Involved In Immune Response Protein Deneddylation Metal-dependent Deubiquitinase Activity Regulation Of Fibroblast Proliferation Regulation Of Protein Neddylation Protein Neddylation Regulation Of Fatty Acid Biosynthetic Process Cytokine-mediated Signaling Pathway MHC Class II Protein Binding, Via Antigen Binding Groove Lymphocyte Activation Involved In Immune Response NOS2-CD74 Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Macrophage Migration Inhibitory Factor Signaling Pathway Cell Activation Involved In Immune Response Regulation Of Protein Modification Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Protein Metabolic Process Antigen Processing And Presentation Of Exogenous Antigen Leukocyte Activation Involved In Immune Response B Cell Mediated Immunity Protein-containing Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immunoglobulin Mediated Immune Response Negative Regulation Of Stem Cell Proliferation Embryonic Organ Development Embryonic Placenta Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Multivesicular Body, Internal Vesicle Lumen Leukocyte Apoptotic Process IgE Receptor Activity Farnesyl Diphosphate Kinase Activity Succinyl-CoA Binding Protein Phosphatase 2A Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition COP9 Signalosome Protein-N-terminal Glutamine Amidohydrolase Activity Nucleus Negative Regulation Of Apoptotic Process Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Fibroblast Proliferation Regulation Of Lymphocyte Apoptotic Process Protein Complex Oligomerization Regulation Of Apoptotic Process
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