ABL2 and GPX1

Number of citations of the paper that reports this interaction (PubMedID 12893824)
0

Data Source:
BioGRID (affinity chromatography technology, pull down, enzymatic study)
HPRD (in vitro)

		ABL2	GPX1
Description		ABL proto-oncogene 2, non-receptor tyrosine kinase	glutathione peroxidase 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Lewy Body
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Phosphotyrosine Residue Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Kinase Activity Transferase Activity Enzyme Binding Manganese Ion Binding Metal Ion Binding Actin Filament Binding	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Oxidoreductase Activity SH3 Domain Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity Protein Tyrosine Kinase Binding
	Biological Process	Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Autophagy Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Endocytosis Regulation Of Cell Adhesion Regulation Of Actin Cytoskeleton Organization Cellular Response To Oxidative Stress Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Protein Modification Process Cellular Response To Retinoic Acid Positive Regulation Of Establishment Of T Cell Polarity Regulation Of Cell Motility Positive Regulation Of T Cell Migration	Response To Reactive Oxygen Species Temperature Homeostasis Endothelial Cell Development Negative Regulation Of Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Triglyceride Metabolic Process Glutathione Metabolic Process Apoptotic Process Response To Oxidative Stress Sensory Perception Of Sound Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Symbiotic Bacterium Response To Wounding Response To Toxic Substance UV Protection Response To Hormone Response To Glucose Response To Selenium Ion Response To Gamma Radiation Myotube Differentiation Arachidonate Metabolic Process Lipoxygenase Pathway Response To Estradiol Response To Lipopolysaccharide Response To Hydroperoxide Response To Vitamin E Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Oxidative Stress Response To Nicotine Epigenetic Regulation Of Gene Expression Vasodilation Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Skeletal Muscle Tissue Regeneration Blood Vessel Endothelial Cell Migration Fat Cell Differentiation Myoblast Differentiation Cell Redox Homeostasis Fibroblast Proliferation Skeletal Muscle Fiber Development Neuron Apoptotic Process Myoblast Proliferation Response To Folic Acid Biological Process Involved In Interaction With Symbiont Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Heart Contraction Angiogenesis Involved In Wound Healing Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Glucose Stimulus Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Oxidant Detoxification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization
Pathways		Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling RAC1 GTPase cycle RAC3 GTPase cycle Negative regulation of FLT3	Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species
Drugs		ATP Dasatinib XL228 K-00546 Fostamatinib	Glutathione Glutathione Glutathione disulfide Cannabidiol Benzoyl peroxide Medical Cannabis Nabiximols
Diseases			Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		IgE grass sensitization ( 22036096)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 23128233 28067908) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827)
Interacting Genes		34 interacting genes: ABL1 AR BCR CAT COXFA4L3 CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK KIT MAP3K10 MDM2 MET NEDD4 NEDD4L OIP5 PDGFRB PIK3R3 PRRG4 PSMA7 RIN1 SIVA1 SORBS2 STAT3 TPD52L1 TRIP10 ZMAT1	16 interacting genes: ABL1 ABL2 ACKR2 CAMP CFTR CISH EBNA1BP2 FAM9B IDH2 ITGA9 MAPK6 MLH1 MST1R RHOA SELENBP1 UQCRC1
Entrez ID		27	2876
HPRD ID		01259	11749
Ensembl ID		ENSG00000143322	ENSG00000233276
Uniprot IDs		P42684	A0A2R8Y6B6 P07203 Q7L4Q3
PDB IDs		2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH 5NP3 5NP5	2F8A
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Kinase Activity Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB Signaling Pathway Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Phosphotyrosine Residue Binding Regulation Of Programmed Cell Death Phosphorylation Peptidyl-tyrosine Phosphorylation Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Population Proliferation Receptor Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of Cell Motility Regulation Of Signaling Regulation Of Cell Communication Response To Growth Factor Positive Regulation Of Locomotion Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Migration Basal Plasma Membrane Transferase Activity Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Biological Quality Regulation Of Cell Motility Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Locomotion	Positive Regulation Of T Cell Migration Positive Regulation Of Establishment Of T Cell Polarity Regulation Of Establishment Of T Cell Polarity Positive Regulation Of Lymphocyte Migration Regulation Of T Cell Migration Enzyme Binding Regulation Of Vasoconstriction Regulation Of Lymphocyte Migration Enzyme Activator Activity Cellular Response To Lipid Positive Regulation Of Mononuclear Cell Migration Odontogenesis Regulation Of Modification Of Synaptic Structure Positive Regulation Of Lymphocyte Activation Regulation Of Establishment Of Cell Polarity Actin Monomer Binding Protein Tyrosine Kinase Activity Synaptonemal Complex Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Osteoblast Proliferation Mismatch Repair Cell-substrate Adhesion Regulation Of Tube Size Regulation Of Establishment Or Maintenance Of Cell Polarity Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Vasoconstriction Positive Regulation Of Cell Activation Nucleotide Binding Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Lipopolysaccharide Response To Lipid Magnesium Ion Binding Cellular Response To Molecule Of Bacterial Origin Cellular Response To Oxygen-containing Compound Phosphotyrosine Residue Binding Substrate Adhesion-dependent Cell Spreading Protein Localization To Cytoplasmic Microtubule Plus-end Positive Regulation Of Developmental Process Immune System Process Non-membrane Spanning Protein Tyrosine Kinase Activity Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Prostaglandin Production Involved In Inflammatory Response Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?