CYFIP2 and ZC3H12A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CYFIP2	ZC3H12A
Description		cytoplasmic FMR1 interacting protein 2	zinc finger CCCH-type containing 12A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane SCAR Complex Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome	P-body Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytoskeleton Membrane Rough Endoplasmic Reticulum Membrane Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	RNA 7-methylguanosine Cap Binding Protein Binding Small GTPase Binding	DNA Binding Chromatin Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity RNA Exonuclease Activity RNA Nuclease Activity Cysteine-type Deubiquitinase Activity Protein Binding Zinc Ion Binding Hydrolase Activity MiRNA Binding RNA Stem-loop Binding MRNA 3'-UTR AU-rich Region Binding Ribosome Binding Metal Ion Binding
	Biological Process	Cell Morphogenesis Apoptotic Process Cell Adhesion Axon Guidance Cell Projection Assembly Regulation Of Actin Filament Polymerization Neuron Projection Development Positive Regulation Of Proteolysis Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Dendrite Extension Cell-cell Adhesion Regulation Of Postsynapse Assembly	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Defense Response To Virus By Host Immune System Process Immune Response-activating Signaling Pathway MRNA Catabolic Process Apoptotic Process Inflammatory Response DNA Damage Response Nervous System Development Regulation Of Gene Expression Positive Regulation Of Autophagy MiRNA Catabolic Process Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Lipid Storage Protein Deubiquitination Cell Differentiation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Oxidative Stress Cellular Response To Glucose Starvation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Macrophage Activation Negative Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Genome Replication Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Protein Complex Oligomerization Defense Response To Virus Negative Regulation Of Cardiac Muscle Contraction Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of P38MAPK Cascade Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Deubiquitination Cellular Response To Sodium Arsenite Cellular Response To Ionomycin Cellular Response To Chemokine Negative Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of MiRNA Catabolic Process
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of CDH19 Expression and Function
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Asthma ( 31959851 32296059 34103634) Daytime sleep phenotypes ( 27126917) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 28166213 30804560) Peak expiratory flow ( 30804560) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)	Eyebrow thickness ( 26926045) Mean corpuscular hemoglobin ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		23 interacting genes: ABI1 ABI3 APBB1 BIRC3 BRK1 DNMBP F2RL1 FMR1 FXR1 FXR2 GAS7 MTDH NCK1 NCKAP1 OXTR PLG PRPF40A SMAD4 TCERG1 WASF1 WASF2 YWHAG ZC3H12A	19 interacting genes: AHSP AIMP2 BTRC CYFIP2 DNAJB13 EP300 HIF1A IKBKG IL6 IRAK2 KPNA2 P4HA3 SHBG SMAD3 TANK TRIM55 TRIM63 UBC ZC3H12D
Entrez ID		26999	80149
HPRD ID		07556	08021
Ensembl ID		ENSG00000055163	ENSG00000163874
Uniprot IDs		B7Z8N7 E7EVJ5 Q96F07	A0A1W2PQC8 Q5D1E8
PDB IDs			3V32 3V33 3V34
Enriched GO Terms of Interacting Partners?		SCAR Complex Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Actin Nucleation Lamellipodium Organization Lamellipodium Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cell Projection Morphogenesis Positive Regulation Of Supramolecular Fiber Organization Lamellipodium Morphogenesis Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Nucleation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Lamellipodium Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Cell Motility Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Supramolecular Fiber Organization Regulation Of Cell Projection Assembly Regulation Of Actin Filament-based Process Postsynapse Cell Projection Organization Regulation Of Lamellipodium Organization Regulation Of Biological Quality Regulation Of Actin Filament Organization Cell Migration Regulation Of Plasma Membrane Bounded Cell Projection Organization Synapse Regulation Of Cell Projection Organization Translation Regulator Activity Positive Regulation Of Translation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Biogenesis Signaling Adaptor Activity Regulation Of Cytoskeleton Organization Cytoplasmic Ribonucleoprotein Granule Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Component Organization Signal Transduction Presynapse Positive Regulation Of Lamellipodium Organization Lamellipodium Assembly RNA Strand Annealing Activity Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Metabolic Process MRNA 3'-UTR Binding	Canonical NF-kappaB Signal Transduction Response To Interleukin-1 Non-canonical NF-kappaB Signal Transduction Apoptotic Process Regulation Of Glycolytic Process Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Nuclear Receptor Binding Positive Regulation Of Signal Transduction Transcription Coactivator Binding Ubiquitin Protein Ligase Binding Vascular Endothelial Growth Factor Production Positive Regulation Of MiRNA Transcription Regulation Of Transforming Growth Factor Beta2 Production Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Programmed Cell Death Cell Death Positive Regulation Of MiRNA Metabolic Process Regulation Of Cytokine-mediated Signaling Pathway Response To Virus Hemoglobin Metabolic Process Positive Regulation Of Proteolysis Regulation Of ATP Metabolic Process Immune System Process Cellular Response To Virus Regulation Of MiRNA Transcription T-helper 17 Cell Lineage Commitment TOR Signaling Regulation Of Purine Nucleotide Metabolic Process Regulation Of Intracellular Signal Transduction Response To Other Organism Regulation Of MiRNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Cytoplasm DNA-binding Transcription Repressor Activity T-helper Cell Lineage Commitment Positive Regulation Of Protein Metabolic Process Beta-catenin Binding Positive Regulation Of Cytokine Production Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Gene Expression Immune Response-regulating Cell Surface Receptor Signaling Pathway CD4-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment Positive Regulation Of Catabolic Process Positive Regulation Of Metabolic Process
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