SEC22A and TMEM174

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SEC22A	TMEM174
Description		SEC22 homolog A, vesicle trafficking protein	transmembrane protein 174
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	SNAP Receptor Activity Protein Binding	Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Membrane Fusion	Phosphate Ion Homeostasis
Pathways		COPII-mediated vesicle transport
Drugs
Diseases
GWAS		Gestational age at birth (maternal effect) ( 28877031)	Blood urea nitrogen levels ( 29403010) Eyebrow thickness ( 26926045) Hemoglobin levels ( 33491795) Monobrow ( 27182965) Monobrow thickness ( 26926045) Renal function-related traits (BUN) ( 22797727)
Interacting Genes		108 interacting genes: ADGRG3 AQP6 ASGR2 ATP6AP2 BIK BNIP3 C10orf67 C16orf54 C16orf92 CALN1 CD207 CD300A CD7 CD74 CISD2 CLEC10A CLEC12B CLEC2D CLEC7A CREB3L1 CYB561 CYBRD1 DDIT4L DIABLO DTX2 EDA ELOVL4 ERLIN1 ERVFRD-1 FAM174A FAM209A FATE1 FUT3 GAD2 GGT6 GJB5 GJB6 GPR37L1 GRAMD2B HAVCR2 HCST HSD17B11 ICAM3 KCNJ2 LDAF1 LDLRAD1 LHFPL5 LMNA LPAR6 LRRC25 LSMEM2 MCOLN1 MFF MGST2 MINAR1 MS4A14 MS4A3 MS4A4A MSR1 OPRM1 PACC1 PEX12 PHB1 PTGES RASGRP4 RETREG3 RILPL1 RNASEK RNF144A RNF19B RNF5 SAR1A SCN3B SDHAF2 SFTPC SLC10A1 SLC14A2 SLC18A1 SLC30A2 SLC35H1 SLC39A2 SMIM3 SPAG4 STMN4 STOML3 STX1A STX2 STX4 SUSD3 SYNE4 TFR2 TLCD4 TMED9 TMEM106C TMEM174 TMEM237 TMEM45B TMEM52B TMEM71 TMEM79 TMIE TMPRSS2 TNFSF14 TP53INP1 TRAT1 TRIM59 TYRP1 ZFYVE27	11 interacting genes: BAG3 CACNB2 CMTM7 CYSRT1 EMD KRT31 KRT34 MAL PLLP SEC22A SGTA
Entrez ID		26984	134288
HPRD ID		15313	14432
Ensembl ID		ENSG00000121542	ENSG00000164325
Uniprot IDs		Q96IW7	Q8WUU8
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Lysosomal Membrane PH-gated Chloride Channel Activity Transmembrane Transport Pattern Recognition Receptor Activity Ascorbate Homeostasis Icosanoid Biosynthetic Process Endoplasmic Reticulum-autophagosome Adaptor Activity Transmembrane Monodehydroascorbate Reductase Activity D-mannose Binding	Structural Constituent Of Myelin Sheath Positive Regulation Of Protein Export From Nucleus Epidermis Development Regulation Of Protein Export From Nucleus Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Cellular Localization Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential TMEM240-body Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Intracellular Protein Transport Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Protein Insertion Into Plasma Membrane Myelination Axon Ensheathment Membrane Raft Polarization Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Protein Insertion Into Membrane TRC Complex Regulation Of Transcytosis B-1a B Cell Differentiation Regulation Of Nucleocytoplasmic Transport Protein Localization To Paranode Region Of Axon BAT3 Complex Binding Compact Myelin B-1 B Cell Differentiation Membrane Depolarization During AV Node Cell Action Potential Supramolecular Fiber Organization Peptidase Activator Activity Involved In Apoptotic Process Positive Regulation Of Aggrephagy Positive Regulation Of Intracellular Transport Localization Within Membrane Photoreceptor Ribbon Synapse Regulation Of Intracellular Protein Transport Developmental Process Intermediate Filament Membrane Raft Distribution Negative Regulation Of ERAD Pathway Chaperone-mediated Autophagy Negative Regulation Of Protein Targeting To Mitochondrion Aggresome Assembly Cortical Endoplasmic Reticulum Membrane Raft Localization Negative Regulation Of Establishment Of Protein Localization To Mitochondrion
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