GJA1 and PRKCG

Number of citations of the paper that reports this interaction (PubMedID 10871288)
55

Data Source:
HPRD (in vitro, in vivo)

		GJA1	PRKCG
Description		gap junction protein alpha 1	protein kinase C gamma
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Gap Junction Connexin Complex Focal Adhesion Intercalated Disc Membrane Apical Plasma Membrane Cell Junction Golgi-associated Vesicle Membrane Cell-cell Contact Zone Membrane Raft Tight Junction Anchoring Junction	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Membrane Dendrite Cell Projection Neuron Projection Calyx Of Held Synapse Perinuclear Region Of Cytoplasm Synaptic Membrane Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Gap Junction Channel Activity Protein Binding Beta-catenin Binding Monoatomic Ion Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity Tubulin Binding Transmembrane Transporter Activity Glutathione Transmembrane Transporter Activity Alpha-tubulin Binding Gap Junction Hemi-channel Activity Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Cardiac Conduction System Development Cell Communication Signal Transduction Cell-cell Signaling Spermatogenesis Heart Development Intracellular Protein Localization Positive Regulation Of Gene Expression Cell Communication By Electrical Coupling Glutamate Secretion Gap Junction Assembly Negative Regulation Of Cell Growth Negative Regulation Of Gonadotropin Secretion Monoatomic Ion Transmembrane Transport Glutathione Transmembrane Transport Maintenance Of Blood-brain Barrier Xenobiotic Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Cell-cell Junction Organization Bone Remodeling Transmembrane Transport Bone Development Atrial Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Microtubule-based Transport Positive Regulation Of Cold-induced Thermogenesis Export Across Plasma Membrane Negative Regulation Of Trophoblast Cell Migration Regulation Of Blood Circulation Cellular Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Morphogenesis Of An Epithelium Positive Regulation Of Mesodermal Cell Differentiation Positive Regulation Of Stem Cell Proliferation	Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Learning Or Memory Chemosensory Behavior Response To Toxic Substance Negative Regulation Of Protein Ubiquitination Regulation Of Response To Food Positive Regulation Of Mismatch Repair Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Circadian Rhythm Response To Morphine Negative Regulation Of Neuron Apoptotic Process Response To Pain Rhythmic Process Regulation Of Phagocytosis Long-term Synaptic Potentiation Innervation Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Signaling Via Neuropeptide Negative Regulation Of Proteasomal Protein Catabolic Process Response To Angiotensin Response To Psychosocial Stress Regulation Of Synaptic Vesicle Exocytosis
Pathways		Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly Gap junction assembly Gap junction degradation Regulation of gap junction activity Regulation of gap junction activity Formation of annular gap junctions RHOQ GTPase cycle RHOJ GTPase cycle SARS-CoV-2 targets PDZ proteins in cell-cell junction Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Calmodulin induced events Disinhibition of SNARE formation Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events WNT5A-dependent internalization of FZD4 Response to elevated platelet cytosolic Ca2+
Drugs		Carvedilol	Tamoxifen Staurosporine Dequalinium Benzoyl peroxide Fostamatinib
Diseases		Deafness, autosomal recessive Oculodentodigital dysplasia Syndactyly	Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Atrial fibrillation ( 29892015 28416822 28416818) Disease progression in age-related macular degeneration ( 29346644) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Focal epilepsy (with hippocampal sclerosis) ( 30531953) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels ( 32203549) Heart rate ( 23583979) Heel bone mineral density ( 30598549) Migraine ( 27322543) Peak creatinine levels in vancomycin therapy ( 26030142) PR interval ( 32439900) Protein quantitative trait loci ( 18464913) Pulse pressure ( 27841878 28135244) Resting heart rate ( 20639392 29769521 23183192 27798624) RR interval (heart rate) ( 30679814) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Tendinopathy ( 31615970) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		30 interacting genes: AKT1 CAV1 CCN3 CFLAR CNST CREB3 CSK CSNK1D GABARAP GJA3 GJA5 HTR2C ITCH MAPK1 MAPK3 MAPK7 NEDD4 NINJ2 PLPP4 PRKCA PRKCB PRKCE PRKCG S100A1 SGSM3 SRC TJP1 TMEM128 TMEM86B UBQLN4	66 interacting genes: AFAP1 ANXA7 APP ARHGEF25 ARHGEF7 CASR CCHCR1 CD5 CDC42 CHAT CTNNB1 CYTH2 DAB2 DNAJC5 DVL2 EIF4E EPHB1 EXOC5 FBXO7 GABRA1 GABRA4 GFAP GJA1 GJA3 GRIA4 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A HABP4 HSPA4 IRS1 ITGB2 LAIR1 MAPT MARK4 NOXA1 NRGN NUMB PA2G4 PABPC4 PARD3 PARD6A PARD6B PDLIM5 PEBP1 PICK1 PNMA1 PPP1R14A RANBP10 RGS2 RIGI SCN3A SDC2 SMURF1 STXBP1 TIAM1 TOP2A TRIM5 UBE2T VTN YWHAB YWHAE YWHAG
Entrez ID		2697	5582
HPRD ID		00414	01502
Ensembl ID		ENSG00000152661	ENSG00000126583
Uniprot IDs		P17302	A0A804HIU5 B2R5T1 B7Z3W6 P05129
PDB IDs		2LL2 7F92 7F93 7F94 7XQ9 7XQB 7XQD 7XQF 7XQG 7XQH 7XQI 7XQJ 7Z1T 7Z22 7Z23 8QKO	2E73 2UZP
Enriched GO Terms of Interacting Partners?		Regulation Of Transport Regulation Of Protein Catabolic Process Protein Kinase Activity Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Gap Junction Regulation Of Vesicle-mediated Transport Kinase Activity Protein Phosphorylation Regulation Of Cell Communication Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine Kinase Activity Regulation Of Protein Metabolic Process Immune Response-activating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Localization Phosphorylation Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Catabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Signal Transduction Signal Transduction Regulation Of Signaling Regulation Of Proteasomal Protein Catabolic Process Caveolin-mediated Endocytosis Connexin Binding Positive Regulation Of Immune System Process Positive Regulation Of Cell Communication Positive Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Regulation Of Cell-cell Adhesion Regulation Of Proteolysis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Signaling Negative Regulation Of Transport Positive Regulation Of Locomotion Lipopolysaccharide-mediated Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Plasma Membrane Response To Peptide Hormone Regulation Of Immune System Process Response To Growth Factor Negative Regulation Of Apoptotic Process Intracellular Signaling Cassette	Cytoplasm Regulation Of Synaptic Plasticity Regulation Of Membrane Potential Postsynapse Regulation Of Cell Communication Regulation Of Signaling Plasma Membrane Cytosol Regulation Of Cell Projection Organization Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Cell-cell Signaling Regulation Of Transport Signaling Cell Junction Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Communication Chemical Synaptic Transmission Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Protein Localization Postsynaptic Membrane Regulation Of Biological Quality Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Focal Adhesion Regulation Of Signal Transduction Neuron Projection Cell Junction Assembly PAR Polarity Complex Protein Kinase C Binding Protein Kinase Binding Regulation Of System Process Positive Regulation Of Synaptic Transmission Positive Regulation Of Cell Communication Positive Regulation Of Signaling NMDA Glutamate Receptor Activity Glutamate Binding Developmental Process Positive Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Regulation Of Neuronal Synaptic Plasticity Anchoring Junction Monoatomic Ion Channel Activity Positive Regulation Of Cellular Component Organization Regulation Of Presynaptic Membrane Potential NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity
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