GHRH and GHRHR

Number of citations of the paper that reports this interaction (PubMedID 10537133)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		GHRH	GHRHR
Description		growth hormone releasing hormone	growth hormone releasing hormone receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Terminal Bouton Perikaryon	Nuclear Inner Membrane Nuclear Outer Membrane Cytoplasm Plasma Membrane Cell Surface Membrane Nuclear Matrix Secretory Granule Sarcolemma
	Molecular Function	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Growth Hormone-releasing Hormone Activity Growth Hormone-releasing Hormone Receptor Binding Peptide Hormone Receptor Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Growth Hormone-releasing Hormone Receptor Activity Peptide Hormone Binding Growth Factor Binding
	Biological Process	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Adenohypophysis Development Growth Hormone Secretion Response To Food Regulation Of Protein Localization Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Circadian Sleep/wake Cycle, REM Sleep Hormone Secretion Positive Regulation Of Hormone Secretion Positive Regulation Of Growth Hormone Secretion Positive Regulation Of CAMP/PKA Signal Transduction	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Lactation Positive Regulation Of Cell Population Proliferation Determination Of Adult Lifespan Adenohypophysis Development Growth Hormone Secretion Mammary Gland Development Response To Insulin Cellular Response To Insulin Stimulus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Estrogen Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Hormone Secretion Positive Regulation Of Hormone Secretion Cell Maturation Regulation Of Protein Metabolic Process Response To Glucocorticoid Establishment Of Localization In Cell Positive Regulation Of Growth Hormone Secretion Somatotropin Secreting Cell Development Cellular Response To Glucose Stimulus CAMP/PKA Signal Transduction
Pathways		G alpha (s) signalling events Glucagon-type ligand receptors	G alpha (s) signalling events Glucagon-type ligand receptors
Drugs			Sermorelin Tesamorelin
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Height ( 31562340)	Triglyceride levels ( 34074324)
Interacting Genes		2 interacting genes: GHRHR SNCA	3 interacting genes: GHRH GHRL MLNR
Entrez ID		2691	2692
HPRD ID		11752	00748
Ensembl ID		ENSG00000118702	ENSG00000106128
Uniprot IDs		P01286	A0A090N8Y6 Q02643
PDB IDs		5BQM 7CZ5 7V9M	2XDG 7CZ5
Enriched GO Terms of Interacting Partners?		Nuclear Outer Membrane Signal Release Somatotropin Secreting Cell Development Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Secretion Growth Hormone-releasing Hormone Receptor Activity Positive Regulation Of Secretion By Cell Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Secretion By Cell Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Growth Hormone Secretion Dopamine Uptake Involved In Synaptic Transmission Secretion CAMP/PKA Signal Transduction Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Adenohypophysis Development Positive Regulation Of Growth Hormone Secretion Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding Regulation Of Chaperone-mediated Autophagy Response To Iron(II) Ion Dopamine Biosynthetic Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Regulation Of Secretion By Cell Regulation Of Acyl-CoA Biosynthetic Process Supramolecular Fiber Catecholamine Uptake Dopamine Uptake Positive Regulation Of Inositol Phosphate Biosynthetic Process Regulation Of Secretion Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway SNARE Complex Assembly Cellular Response To Epinephrine Stimulus Regulation Of Growth Hormone Secretion	Growth Hormone-releasing Hormone Activity Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Growth Hormone Secretion Positive Regulation Of Growth Hormone Secretion Regulation Of Growth Hormone Secretion Positive Regulation Of Circadian Rhythm Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle Positive Regulation Of Behavior Positive Regulation Of Multicellular Organism Growth Regulation Of Multicellular Organism Growth Peptide Hormone Secretion Regulation Of Behavior Peptide Secretion Hormone Secretion G Protein-coupled Receptor Signaling Pathway Peptide Transport Hormone Transport Positive Regulation Of Peptide Hormone Secretion Regulation Of Circadian Rhythm Positive Regulation Of Peptide Secretion Hormone Activity Positive Regulation Of Circadian Sleep/wake Cycle, REM Sleep Growth Hormone-releasing Hormone Receptor Binding Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation Amide Transport Positive Regulation Of Hormone Secretion Signal Release Positive Regulation Of Developmental Growth Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate Regulation Of Peptide Hormone Secretion Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Bone Development Positive Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Hormone Secretion Positive Regulation Of Growth Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Appetite Regulation Of Gastric Motility Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Secretion By Cell Neuronal Dense Core Vesicle Lumen
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