GFAP and STAT1

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		GFAP	STAT1
Description		glial fibrillary acidic protein	signal transducer and activator of transcription 1
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GO Annotations	Cellular Component	Cytoplasm Lysosome Cytosol Cytoskeleton Intermediate Filament Membrane Cell Projection Cell Body Intermediate Filament Cytoskeleton Glial Cell Projection Astrocyte Projection Astrocyte End-foot Cytoplasmic Side Of Lysosomal Membrane	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Axon Dendrite Protein-containing Complex Perinuclear Region Of Cytoplasm ISGF3 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Kinase Binding Identical Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding Transcription Coactivator Binding DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Tumor Necrosis Factor Receptor Binding Protein Binding Enzyme Binding CCR5 Chemokine Receptor Binding Histone Acetyltransferase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Ubiquitin-like Protein Ligase Binding Cadherin Binding Protein Phosphatase 2A Binding Promoter-specific Chromatin Binding
	Biological Process	Intracellular Protein Transport Gene Expression Positive Regulation Of Schwann Cell Proliferation Negative Regulation Of Neuron Projection Development Astrocyte Development Schwann Cell Proliferation Extracellular Matrix Organization Neuron Projection Regeneration Neuron Projection Development Regulation Of Protein-containing Complex Assembly Intermediate Filament-based Process Intermediate Filament Organization Regulation Of Neurotransmitter Uptake Bergmann Glial Cell Differentiation Positive Regulation Of Glial Cell Proliferation Long-term Synaptic Potentiation D-aspartate Import Across Plasma Membrane Regulation Of Chaperone-mediated Autophagy	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Defense Response To Virus By Host Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Nutrient Blood Circulation Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Mechanical Stimulus Negative Regulation Of Angiogenesis Positive Regulation Of Interferon-alpha Production Cellular Response To Insulin Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Response To Type II Interferon Response To Interferon-beta Cellular Response To Interferon-beta Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Hydrogen Peroxide Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Response To Peptide Hormone Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Developmental Process Response To CAMP Defense Response To Virus Type II Interferon-mediated Signaling Pathway Type I Interferon-mediated Signaling Pathway Renal Tubule Development Interleukin-27-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cellular Response To Type II Interferon Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT
Pathways		Nuclear signaling by ERBB4 Chaperone Mediated Autophagy	Interleukin-6 signaling ISG15 antiviral mechanism Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Interleukin-4 and Interleukin-13 signaling Interleukin-20 family signaling Regulation of RUNX2 expression and activity Interleukin-35 Signalling Interleukin-9 signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Interleukin-27 signaling Interleukin-21 signaling Interferon alpha/beta signaling Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells Inactivation of CSF3 (G-CSF) signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Signaling by ALK fusions and activated point mutants Growth hormone receptor signaling PKR-mediated signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Regulation of PD-L1(CD274) transcription
Drugs
Diseases		Alexander disease	Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF) IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Asthma ( 31619474) Cognitive function ( 25644384) Craniofacial microsomia ( 26853712)	Birth weight ( 31043758) Height ( 31562340) Inflammatory bowel disease ( 23128233) JT interval (sulfonylurea treatment interaction) ( 27958378) Limited cutaneous systemic scleroderma ( 29293537) Lung cancer (SNP x SNP interaction) ( 24325914) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Primary biliary cholangitis ( 26394269 28425483) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 26316170) Systemic sclerosis ( 29293537)
Interacting Genes		86 interacting genes: ABI2 AKT1 APP AURKB BIRC2 CAMK2A CARD10 CCDC57 CDC37 CDK1 CEP76 CFAP206 CRYAB CT55 CWF19L2 DSCAM ENKD1 EPM2AIP1 FAM50B FXR1 FXR2 GOLGA2 GRAP2 HGS HOMEZ IKBKG ITSN1 KIAA0408 KRT13 KRT15 KRT19 KRT27 KRT31 KRT39 LENG1 LGALS14 LMO2 MAPK9 MEN1 MOS MYBPHL MYO15B NEFL NEIL3 NEK6 NFKBID NTAQ1 NXF1 PDLIM1 PDLIM7 PDZK1 PIAS2 PIH1D2 POM121 PPP1R16B PPP1R18 PRKACA PRKCA PRKCG PSEN1 PSEN2 RIBC2 ROCK1 RORA S100A1 S100B SH3YL1 SMARCA2 SMARCB1 SRC STAT1 TBC1D21 TBC1D22B TFIP11 TLE5 TP53BP2 TRIM27 TSC1 TUBGCP4 UBASH3A UBE3A VIM YES1 ZC2HC1C ZNF655 ZNF774	113 interacting genes: ACTN4 ADRA1B AIRN AKT1 ATF3 BMX BRCA1 CAMK2A CAMK2D CAMK2G CASP3 CASP7 CCR1 CCR5 CDC42 CEBPA CREBBP CSE1L CSF2RB CXCR4 DCTN1 DDB1 DDX6 DOT1L DUSP2 DUSP3 E2F1 EGFR EIF1AD EIF2AK2 ELP2 EP300 FADD FANCC FGFR3 FGFR4 FLT1 FOS FTH1 FYN GFAP GTF2I HADH HLA-B HSF1 HSP90AB1 HSPA8 IFNAR2 IFNGR1 IL27RA IL2RB IL2RG IRF1 IRF2 IRF9 JAK1 JAK2 JUN KDR KIT KPNA1 KPNA6 LCK LMO2 LZTR1 MAPK14 MAVS MCM3 MCM5 MDK MFSD6 MT-ND4L NMI NOMO1 NOMO2 OTUD4 PDGFRA PDGFRB PIAS1 PIAS2 PIK3CA PKNOX1 POR PRKCD PRMT1 PRMT3 PTK2 PTPN11 PTPN2 RAC1 RACK1 RELA RPS6KA5 RXRA SHANK1 SPTAN1 SPTB SPTBN1 SRC STAT2 STAT3 STAT5A STAT5B SUMO4 SYK TNFRSF1A TNFRSF1B TRADD TYK2 UBE2I VDR XPO1 ZNF467
Entrez ID		2670	6772
HPRD ID		00675	02777
Ensembl ID		ENSG00000131095	ENSG00000115415
Uniprot IDs		A0A1X7SBR3 P14136	A0A669KB68 A0A8V8TN81 P42224
PDB IDs		6A9P	1BF5 1YVL 2KA6 3WWT 7NUF 8D3F
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Intermediate Filament Organization Cytoskeleton Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Binding Protein Serine/threonine/tyrosine Kinase Activity Intracellular Signal Transduction Structural Constituent Of Skin Epidermis Cytoplasm Protein Kinase Activity Intermediate Filament Protein Serine Kinase Activity Regulation Of Cellular Component Organization Microtubule Cytoskeleton Organization Organelle Organization Response To Peptide Hormone Positive Regulation Of Signaling Regulation Of Generation Of Precursor Metabolites And Energy Protein Serine/threonine Kinase Activity Protein-containing Complex Keratin Filament Regulation Of Synaptic Plasticity Protein Phosphorylation Nucleus Kinase Activity Regulation Of Neuronal Synaptic Plasticity Structural Constituent Of Cytoskeleton Response To Hormone Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Cytosol Regulation Of Sister Chromatid Segregation Regulation Of Cell Cycle Regulation Of Apoptotic Process Synaptic Membrane Mitotic Nuclear Membrane Disassembly Developmental Process Negative Regulation Of TORC1 Signaling Intracellular Signaling Cassette Regulation Of Proteolysis Phosphorylation Regulation Of Circadian Rhythm Regulation Of Signaling Positive Regulation Of Gene Expression Regulation Of Cell Communication Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Structural Molecule Activity	Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Metabolic Process Signal Transduction Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Primary Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Response To Stress Positive Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Positive Regulation Of Developmental Process Positive Regulation Of Biosynthetic Process Regulation Of Apoptotic Process Immune System Process Protein Kinase Activity Regulation Of Cell Population Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Immune System Process Phosphorylation Protein Phosphorylation Regulation Of Defense Response Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Development Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Kinase Activity Response To Lipid Defense Response Response To Peptide Positive Regulation Of Cell Differentiation
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