NUPR1 and STX18

Number of citations of the paper that reports this interaction (PubMedID 19650074)
0

Data Source:
BioGRID (two hybrid)

		NUPR1	STX18
Description		nuclear protein 1, transcriptional regulator	syntaxin 18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Protein-DNA Complex Intercellular Bridge Perinuclear Region Of Cytoplasm	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane SNARE Complex
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Acetyltransferase Activator Activity	SNAP Receptor Activity Protein Binding Protein Domain Specific Binding
	Biological Process	Acute Inflammatory Response Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Toxic Substance Regulation Of Autophagy Negative Regulation Of Autophagy Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Skeletal Muscle Cell Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Negative Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Negative Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Programmed Necrotic Cell Death Protein-containing Complex Assembly Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Autophagosome Assembly Positive Regulation Of Oxidative Phosphorylation Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Female Gonad Development Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport Membrane Fusion Endoplasmic Reticulum Membrane Organization Positive Regulation Of Organelle Assembly Positive Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Golgi Organization
Pathways			COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30679032) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) Intelligence (MTAG) ( 29326435) Lamb consumption ( 32066663) Offspring birth weight ( 31043758) Refractive error ( 32231278) Urinary metabolite levels in chronic kidney disease ( 31959995)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Chronic rhinosinusitis ( 33393196) Congenital heart disease ( 23708191)
Interacting Genes		17 interacting genes: ABCG8 ALDH1A1 EP300 KNSTRN MAPRE1 MPHOSPH6 MSL1 NPY5R PAXIP1 PTMA RANBP1 RPL41 SEC11A SET STX18 SYNCRIP TUBA4A	6 interacting genes: BNIP1 DISC1 LCOR NSG2 NUPR1 SNCA
Entrez ID		26471	53407
HPRD ID		17814	06923
Ensembl ID		ENSG00000176046	ENSG00000168818
Uniprot IDs		O60356	Q9P2W9
PDB IDs
Enriched GO Terms of Interacting Partners?			Regulation Of Aerobic Respiration Regulation Of Oxidative Phosphorylation Regulation Of Cellular Respiration Kinesin Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Apoptotic Process In Response To Mitochondrial Fragmentation Negative Regulation Of Serotonin Uptake Positive Regulation Of Catabolic Process Transporter Regulator Activity Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Autophagy Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Chaperone-mediated Autophagy Synaptic Vesicle Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Oxidative Phosphorylation Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Calcium-induced Calcium Release Activity Endoplasmic Reticulum Membrane Fusion Negative Regulation Of Dopamine Metabolic Process Molecular Adaptor Activity Cytoplasmic Vesicle Membrane Positive Regulation Of Inflammatory Response Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Perinuclear Region Of Cytoplasm Negative Regulation Of Catecholamine Metabolic Process Regulation Of Serotonin Uptake Golgi Cis Cisterna Membrane Cell Death Negative Regulation Of Programmed Cell Death Programmed Cell Death Apoptotic Process Negative Regulation Of Apoptotic Process Mitochondrial Outer Membrane Presynapse Regulation Of Chaperone-mediated Autophagy Dopamine Uptake Involved In Synaptic Transmission Response To Iron(II) Ion Calcium Ion Homeostasis Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Oxidative Phosphorylation Positive Regulation Of Proteolysis
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