GCH1 and OAZ1

		GCH1	OAZ1
Description		GTP cyclohydrolase 1	ornithine decarboxylase antizyme 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Catalytic Activity GTPase Activity GTP Cyclohydrolase I Activity Protein Binding GTP Binding Zinc Ion Binding Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Mitogen-activated Protein Kinase Binding	Protein Binding Ornithine Decarboxylase Inhibitor Activity
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Type II Interferon Response To Tumor Necrosis Factor Dopamine Biosynthetic Process Pteridine-containing Compound Metabolic Process Pteridine-containing Compound Biosynthetic Process Tetrahydrobiopterin Metabolic Process Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Removal Of Superoxide Radicals	Biogenic Amine Metabolic Process Polyamine Biosynthetic Process Positive Regulation Of Protein Catabolic Process Viral Translational Frameshifting Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Polyamine Transmembrane Transport
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	Regulation of ornithine decarboxylase (ODC) Metabolism of polyamines
Drugs		Guanine	Ornithine
Diseases		Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 27182965 28892059 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963) Serum metabolite levels ( 33031748)
Interacting Genes		25 interacting genes: AHSA1 ATP1B1 ATP6V1A BDH1 CDC37 CHMP4A CNRIP1 GCHFR GIT2 GPATCH2L HNRNPA1 HSPA8 MPPED2 OAZ1 RAB26 RER1 RLF RND3 RPH3A SH3GL2 SP3 TNIP2 TNPO2 TNPO3 YWHAZ	15 interacting genes: AGTR1 ATXN1 EGFR GCH1 HTR2B MUC1 MYCBP2 NLGN3 NRIP1 OAZ2 OAZ3 ODC1 PIAS4 PSMB4 SMAD1
Entrez ID		2643	4946
HPRD ID		02573	03346
Ensembl ID		ENSG00000131979	ENSG00000104904
Uniprot IDs		P30793 Q8IZH9	J3QQY4 P54368
PDB IDs		1FB1 6Z80 6Z85 6Z86 6Z87 6Z88 6Z89 7ALA 7ALB 7ALC 7ALQ	4ZGY 4ZGZ 5BWA
Enriched GO Terms of Interacting Partners?		Establishment Of Localization In Cell GMP Binding Regulation Of Protein Stability Establishment Of Protein Localization Cellular Localization Extrinsic Component Of Synaptic Vesicle Membrane Protein Targeting Protein Kinase Binding ATPase Activator Activity Intracellular Protein Localization MHC Class II Protein Complex Binding Protein Transport Melanosome Protein-folding Chaperone Binding Unfolded Protein Binding Small GTPase Binding Nuclear Import Signal Receptor Activity Import Into Nucleus Intracellular Protein Transport Protein Folding Chaperone Complex Intracellular Transport GTP Cyclohydrolase I Regulator Activity GTP Cyclohydrolase Binding Chaperone-mediated Autophagy Translocation Complex Disassembly Establishment Of Protein Localization To Organelle Exocrine System Development Type 1 Cannabinoid Receptor Binding ATP Metabolic Process Hsp90 Protein Binding	Amine Biosynthetic Process Biogenic Amine Biosynthetic Process Polyamine Biosynthetic Process Biogenic Amine Metabolic Process Polyamine Metabolic Process Amine Metabolic Process Ornithine Decarboxylase Inhibitor Activity Negative Regulation Of Polyamine Transmembrane Transport Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Viral Translational Frameshifting Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process System Process Transcription Coregulator Activity Cellular Response To Estradiol Stimulus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Proliferation Angiotensin Type I Receptor Activity Animal Organ Development Hair Follicle Development Regulation Of Protein Localization Nervous System Process Multivesicular Body, Internal Vesicle Lumen GTP Cyclohydrolase I Activity Ovarian Follicle Rupture Regulation Of Cellular Response To Stress MAPK Cascade Social Behavior Positive Regulation Of MiRNA Transcription Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of MiRNA Metabolic Process Bradykinin Receptor Binding Learning Or Memory Shc-EGFR Complex Endocytic Vesicle Homomeric SMAD Protein Complex Circadian Regulation Of Gene Expression Limb Epidermis Development Regulation Of Cell Population Proliferation Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Cytoplasm Cognition Regulation Of MiRNA Transcription Positive Regulation Of Protein Kinase C Signaling Ubiquitin Protein Ligase Binding
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