GCGR and BIRC5

		GCGR	BIRC5
Description		glucagon receptor	baculoviral IAP repeat containing 5
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Nuclear Chromosome Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Centriole Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Midbody Interphase Microtubule Organizing Center Chromosome Passenger Complex Protein-containing Complex Spindle Midzone Survivin Complex
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Glucagon Receptor Activity Guanyl-nucleotide Exchange Factor Activity Peptide Hormone Binding	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Microtubule Binding Zinc Ion Binding Tubulin Binding Enzyme Binding Peptidase Inhibitor Activity Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Protein Heterodimerization Activity Cobalt Ion Binding Protein-folding Chaperone Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Nutrient Regulation Of Blood Pressure Cellular Response To Starvation Positive Regulation Of Gene Expression Glucose Homeostasis Response To Starvation Regulation Of Glycogen Metabolic Process Cellular Response To Glucagon Stimulus	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Cytokinesis Apoptotic Process Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Protein-containing Complex Localization Positive Regulation Of Exit From Mitosis Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Chromosome Localization Mitotic Spindle Midzone Assembly Cell Division Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis
Pathways		Glucagon signaling in metabolic regulation G alpha (q) signalling events G alpha (s) signalling events Glucagon-type ligand receptors	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Mitotic Prometaphase Neddylation EML4 and NUDC in mitotic spindle formation
Drugs		Glucagon Dasiglucagon	Reserpine Berberine LY2181308
Diseases
GWAS		Hematocrit ( 32888494)	Blood trace element (Se levels) ( 23720494) Periodontitis (Mean PAL) ( 24024966)
Interacting Genes		5 interacting genes: BIRC5 GCG GNAS TGM2 TP63	35 interacting genes: AANAT AKAP6 AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CCDC85B CDCA8 CDK1 CDK4 CSNK1D DIABLO EVI5 FASN GAS2L3 GCGR H3-4 H3C14 HSP90AA1 INCENP KCNJ6 NNMT OGT RAN RASA1 SSH2 STAMBPL1 TLE3 XIAP XPO1
Entrez ID		2642	332
HPRD ID		00678	04520
Ensembl ID		ENSG00000215644	ENSG00000089685
Uniprot IDs		P47871	A0A0B4J1S3 H3BLT4 O15392
PDB IDs		2A83 3CZF 4ERS 4L6R 4LF3 5EE7 5XEZ 6LMK 6LML 6WHC 6WPW 7V35 8FU6 8JIQ 8JIT 8JIU 8JRU 8JRV 8WG8 8YW5	1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N 6SHO 6YIE 6YIF 6YIH 7LBK 7LBO 7LBP 7LBQ 8RUP
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Response To Catecholamine Cellular Response To Catecholamine Stimulus Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Survivin Complex Regulation Of Signal Transduction Bone Development Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Ectoderm And Mesoderm Interaction Epidermal Cell Division Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phagocytosis Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Communication Positive Regulation Of Signaling Glucagon Receptor Binding Gastric Inhibitory Polypeptide Receptor Binding Mu-type Opioid Receptor Binding Protein Deamination Positive Regulation Of Somatic Stem Cell Population Maintenance Cloacal Septation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cellular Response To Serotonin Female Genitalia Morphogenesis Negative Regulation Of Mesoderm Development Regulation Of Epidermal Cell Division G Protein-coupled Receptor Signaling Pathway Signal Transduction Regulation Of Insulin Secretion Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cell Division Positive Regulation Of Exit From Mitosis Cobalt Ion Binding Cellular Response To Peptide Hormone Stimulus Chemical Homeostasis Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Prostatic Bud Formation	Chromosome Passenger Complex Cell Division Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Midbody Mitotic Spindle Midzone Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Midzone Assembly Regulation Of Metaphase Plate Congression Spindle Microtubule Spindle Regulation Of Cytokinesis Spindle Organization Mitotic Spindle Organization Regulation Of Cell Cycle Apoptotic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Programmed Cell Death Cell Death Microtubule Cytoskeleton Organization Spindle Midzone Positive Regulation Of Chromosome Segregation Cytoplasm Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Programmed Cell Death Positive Regulation Of Cell Cycle Process Cytosol Fibroblast Apoptotic Process Spindle Assembly Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cell Division Protein Modification Process Chromocenter Positive Regulation Of Cytokinesis Protein-containing Complex Regulation Of Apoptotic Process Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Neuron Apoptotic Process Transferase Activity Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cell Cycle Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of Cell Cycle Checkpoint Cellular Response To Oxygen-containing Compound Mitotic Cell Cycle Mitotic Cytokinesis Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
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