TINF2 and ENO2

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		TINF2	ENO2
Description		TERF1 interacting nuclear factor 2	enolase 2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Perinucleolar Chromocenter Nuclear Matrix Nuclear Body Shelterin Complex	Phosphopyruvate Hydratase Complex Photoreceptor Inner Segment Extracellular Space Cytoplasm Cytosol Plasma Membrane Cell Cortex Cell Surface Membrane Growth Cone Neuronal Cell Body Perikaryon Membrane Raft Extracellular Exosome Synaptic Membrane
	Molecular Function	DNA Binding Protein Binding Telomeric DNA Binding	Magnesium Ion Binding Phosphopyruvate Hydratase Activity Protein Binding Lyase Activity Enzyme Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening	Gluconeogenesis Glycolytic Process Response To Xenobiotic Stimulus Response To Estradiol Canonical Glycolysis
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Glycolysis Gluconeogenesis
Drugs			2-Phosphoglycolic Acid
Diseases		Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS		Leukocyte telomere length ( 31171785) Platelet count ( 29403010)
Interacting Genes		91 interacting genes: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 ANXA8L1 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CSNK2A1 CTTN DBN1 DCX DHFR2 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 MTNR1B NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS1 SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TFRC TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790	28 interacting genes: A2M ACD AKT1 ANXA11 BMERB1 C6orf47 CD27 ENSA EXOC5 HABP4 HK1 HSF1 IL17B MAP4 MTNR1A NAT9 NDUFS7 POT1 SIGIRR SNUPN ST3GAL2 SUMO4 TERF1 TINF2 TUBA4A UBE2C UBE3A USP2-AS1
Entrez ID		26277	2026
HPRD ID		16056	00573
Ensembl ID		ENSG00000092330	ENSG00000111674
Uniprot IDs		B4DFJ1 Q9BSI4	P09104 Q6FHV6
PDB IDs		3BQO 3BU8 5XYF	1TE6 2AKM 2AKZ 3UCC 3UCD 3UJE 3UJF 3UJR 3UJS 4ZA0 4ZCW 5EU9 5IDZ 5TD9 5TIJ 7MBH
Enriched GO Terms of Interacting Partners?		Cytosol Extracellular Exosome Cytoplasm ADP Metabolic Process Purine Ribonucleotide Catabolic Process Ribonucleoside Diphosphate Metabolic Process Glycolytic Process ADP Catabolic Process Purine Nucleotide Catabolic Process Nucleoside Phosphate Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Cadherin Binding Pyruvate Metabolic Process Nucleotide Catabolic Process Carbohydrate Catabolic Process Shelterin Complex Organophosphate Catabolic Process Glucose Metabolic Process RNA-templated DNA Biosynthetic Process Nuclear Telomere Cap Complex Glucose Catabolic Process Nucleobase-containing Compound Catabolic Process Protein Localization To Chromosome, Telomeric Region ATP Metabolic Process Hexose Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Capping Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Generation Of Precursor Metabolites And Energy Ficolin-1-rich Granule Lumen Nucleobase-containing Small Molecule Metabolic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Phosphoglucomutase Activity Nucleoside Metabolic Process Protein Binding Purine Ribonucleotide Metabolic Process Calcium-dependent Phospholipid Binding Cellular Response To Heat Canonical Glycolysis Negative Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribonucleotide Metabolic Process Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Translation Elongation Factor Binding Negative Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Negative Regulation Of Cellular Component Organization Regulation Of DNA Biosynthetic Process Positive Regulation Of Organelle Organization Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Positive Regulation Of Chromosome Organization Maintenance Of Protein Location In Mitochondrion Regulation Of Telomere Maintenance Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomere Organization Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Organelle Organization Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Regulation Of DNA Metabolic Process Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Chromosome, Telomeric Region Establishment Of Protein Localization To Organelle Organelle Organization DNA Biosynthetic Process Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Cilium Assembly Cell Division Microtubule Cytoskeleton Ubiquitin-like Protein Ligase Binding Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Mitotic Cell Cycle Regulation Of TRNA Methylation
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