TIAM2 and UFD1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		TIAM2	UFD1
Description		TIAM Rac1 associated GEF 2	ubiquitin recognition factor in ER associated degradation 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Lamellipodium Filopodium Growth Cone Cell Projection Neuron Projection Perikaryon Synapse Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity	Cysteine-type Deubiquitinase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Signal Transduction Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production ERAD Pathway Negative Regulation Of RIG-I Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Misfolded Protein
Pathways		NRAGE signals death through JNK PPARA activates gene expression G alpha (12/13) signalling events RAC1 GTPase cycle	Translesion Synthesis by POLH Ub-specific processing proteases Neddylation KEAP1-NFE2L2 pathway Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Appendicular lean mass ( 33097823) Asthma ( 31361310) Dimensional psychopathology (Arousal) ( 29496196) Dimensional psychopathology (Negative) ( 29496196) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Lipoprotein (a) levels ( 26377243) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		9 interacting genes: ANXA7 DISC1 DNM2 H2AX PARD3 SH3GL2 TK1 TNIK UFD1	23 interacting genes: A2M AMFR ANAPC2 CHMP2A F13A1 GZMK HSPB1 IGHM LRRK2 MAP3K1 MASP1 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TMUB1 TP53 UBC VCP
Entrez ID		26230	7353
HPRD ID		05273	06778
Ensembl ID		ENSG00000146426	ENSG00000070010
Uniprot IDs		B3KW11 Q8IVF5	Q541A5 Q92890
PDB IDs			2YUJ 5B6C 5C1B 7WWQ
Enriched GO Terms of Interacting Partners?		Presynapse Cytoskeleton Organization Cell Projection Organization Developmental Process Cell Projection Morphogenesis Neuron Projection Morphogenesis Negative Regulation Of Membrane Tubulation Actin Filament-based Process Intracellular Protein Localization Vesicle Scission Regulation Of Axon Extension Actin Cytoskeleton Organization Phosphatidylinositol-4,5-bisphosphate Binding Thymidine Kinase Activity UFD1-NPL4 Complex Negative Regulation Of Blood-brain Barrier Permeability System Development DNA Synthesis Involved In Mitotic DNA Replication Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Negative Regulation Of Gene Expression Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Recycling Endosome Protein-containing Complex Assembly Glutamatergic Synapse Thymidine Biosynthetic Process Positive Regulation Of Microvillus Assembly Internode Region Of Axon Negative Regulation Of Peptidyl-threonine Phosphorylation	Proteolysis Involved In Protein Catabolic Process Proteolysis Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Intracellular Signaling Cassette BAT3 Complex Binding ERAD Pathway Intracellular Protein Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Macroautophagy Protein Metabolic Process Growth Cone Proteasomal Protein Catabolic Process Cytosol Macromolecule Catabolic Process Derlin-1 Retrotranslocation Complex Protein Transport VCP-NPL4-UFD1 AAA ATPase Complex Ubiquitin-dependent Protein Catabolic Process K48-linked Polyubiquitin Modification-dependent Protein Binding Catabolic Process Intracellular Transport Activation Of Membrane Attack Complex Protein Catabolic Process Negative Regulation Of Complement Activation Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Regulation Of Immune Response Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Opsonization Retrograde Protein Transport, ER To Cytosol Macromolecule Metabolic Process Intracellular Protein Localization Ubiquitin-specific Protease Binding Symbiont Cell Surface Intracellular Signal Transduction Regulation Of Fibroblast Apoptotic Process Ubiquitin Binding Negative Regulation Of Autophagy Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Small GTPase-mediated Signal Transduction Regulation Of Complement Activation MAP Kinase Kinase Kinase Activity Extracellular Space Regulation Of Mitochondrion Organization Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Localization Blood Microparticle
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