FBXL21P and MYOZ1

Number of citations of the paper that reports this interaction (PubMedID 36574402)
75

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		FBXL21P	MYOZ1
Description		F-box and leucine rich repeat protein 21, pseudogene	myozenin 1
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Nucleus Actin Cytoskeleton Z Disc Pseudopodium Cell Projection
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Actin Binding Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Telethonin Binding Actinin Binding FATZ Binding Molecular Condensate Scaffold Activity
	Biological Process	Protein Ubiquitination Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Rhythmic Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Myofibril Assembly Wound Healing Negative Regulation Of Skeletal Muscle Tissue Regeneration Skeletal Muscle Fiber Adaptation Sarcomere Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways
Drugs
Diseases
GWAS			Atrial fibrillation ( 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		3 interacting genes: CRY2 GSK3B MYOZ1	42 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 AKAP8L APP BAG4 BRCA1 CEACAM6 CEP76 CRX EIF3F EXOSC8 FBXL21P FLNA FLNC GOLGA6A GRB2 GSK3B KRT34 KRT36 KRTAP12-2 LDB3 LHX4 LZTS2 MAGEA11 PFDN5 PLEKHG4 PNKP PNMA1 PRKAA2 TCAP TRAF1 TRIM23 TRIM55 TRIM63 USHBP1 VAC14 VBP1 WASHC3 WWOX YPEL3
Entrez ID		26223	58529
HPRD ID		16431	05725
Ensembl ID			ENSG00000177791
Uniprot IDs			Q9NP98
PDB IDs			7A8T 7A8U 7ANK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcium-mediated Signaling Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Intracellular Signal Transduction Regulation Of Calcium-mediated Signaling Photoreactive Repair Regulation Of Circadian Rhythm Circadian Rhythm Regulation Of Microtubule Anchoring At Centrosome Negative Regulation Of Skeletal Muscle Tissue Regeneration Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Signal Transduction Negative Regulation Of Glucocorticoid Secretion Rhythmic Process Negative Regulation Of Cell Communication Cry-Per Complex Negative Regulation Of Signaling Negative Regulation Of TORC2 Signaling Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of Glycogen (starch) Synthase Activity Skeletal Muscle Fiber Adaptation Regulation Of Sodium-dependent Phosphate Transport Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Membraneless Organelle Assembly FATZ Binding Response To Blue Light Regulation Of Developmental Growth Positive Regulation Of Protein Localization To Cilium Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Cellular Response To Interleukin-3 Positive Regulation Of Protein Localization To Centrosome Telethonin Binding Regulation Of Phosphate Transport Regulation Of Intracellular Signal Transduction Pyrimidine Dimer Repair Photoreceptor Activity Negative Regulation Of Glycogen Biosynthetic Process Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Skeletal Muscle Tissue Regeneration Regulation Of Protein Localization To Cilium Positive Regulation Of Protein Binding	Z Disc Pseudopodium Muscle Cell Development Actin Cytoskeleton Organization Actin Filament-based Process Regulation Of Apoptotic Process Transmembrane Transporter Binding Regulation Of Programmed Cell Death Identical Protein Binding Cytoskeleton Organization Sarcomere Organization Titin Binding Regulation Of Supramolecular Fiber Organization Titin Z Domain Binding Actin Filament Binding Regulation Of Glycolytic Process Cortical Actin Cytoskeleton Sarcomere Regulation Of Amyloid Fibril Formation Regulation Of Generation Of Precursor Metabolites And Energy Platelet Alpha Granule Lumen Regulation Of Carbohydrate Catabolic Process Cytoskeletal Protein Binding Integrin Binding Actin Binding Regulation Of ATP Metabolic Process Regulation Of Cytoskeleton Organization Focal Adhesion Assembly Cytosol Cytoplasm Actin Filament Positive Regulation Of Supramolecular Fiber Organization FATZ Binding Skeletal Muscle Atrophy Regulation Of Purine Nucleotide Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Cell-substrate Junction Assembly Skeletal Muscle Adaptation Striated Muscle Atrophy Prefoldin Complex Cell-substrate Junction Organization Anatomical Structure Morphogenesis Structural Constituent Of Muscle Actomyosin Structure Organization Supramolecular Fiber Organization Organelle Organization Muscle Atrophy Positive Regulation Of Organelle Organization Cell Development
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