SENP3 and HIC1

Number of citations of the paper that reports this interaction (PubMedID 17283066)
64

Data Source:
BioGRID (enzymatic study)

		SENP3	HIC1
Description		SUMO specific peptidase 3	HIC ZBTB transcriptional repressor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Body MLL1 Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Proteolysis Protein Desumoylation Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Signal Transduction Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	SUMOylation of transcription factors
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) IgM levels ( 23118916) Refractive error ( 32231278) Serum metabolite levels ( 33031748)	Brain morphology (MOSTest) ( 32665545) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 27863252) Plateletcrit ( 27863252 32888494) Spleen volume ( 34128465)
Interacting Genes		20 interacting genes: ADRB2 ATF7IP BECN1 CDCA8 CDK4 CDK6 CEP19 DNM1L EP300 HIC1 MED25 MTHFD1 NPM1 PARP1 PELP1 SUMO2 TRIM54 TRIM63 USP15 USP21	12 interacting genes: ARID1A CRBN CTBP1 CTBP2 HDAC1 HIC2 MECOM PIAS1 SENP3 SIRT1 TCF7L2 UBE2I
Entrez ID		26168	3090
HPRD ID		08339	04826
Ensembl ID		ENSG00000161956	ENSG00000177374
Uniprot IDs		Q9H4L4	A0PJI1 Q14526
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Transcription Regulator Complex Nucleoplasm Regulation Of Signal Transduction By P53 Class Mediator Regulation Of RNA Metabolic Process Protein-DNA Complex Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Organelle Organization Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromatin Remodeling Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of Metaphase Plate Congression Cellular Response To UV Regulation Of Fibroblast Proliferation Regulation Of Muscle System Process Protein-containing Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Light Stimulus Chromatin Organization Regulation Of Cellular Response To Stress Negative Regulation Of Small Molecule Metabolic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle G2/M Phase Transition Ubiquitin Protein Ligase Binding Negative Regulation Of ATP Metabolic Process Regulation Of Phosphorus Metabolic Process Mononuclear Cell Differentiation Regulation Of Gene Expression Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Small Molecule Metabolic Process	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Transcription Corepressor Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Transcription Corepressor Activity White Fat Cell Differentiation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process PML Body Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Androgen Receptor Signaling Pathway Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway HLH Domain Binding Transcription Coregulator Binding Nuclear Receptor Binding Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of Primary Metabolic Process Transcription Repressor Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Promoter-specific Chromatin Binding Nucleoplasm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Protein Modification Process Transcription Coactivator Activity Protein Deacetylation Protein Lysine Deacetylase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Histone Deacetylase Activity Viral Genome Replication SUMO Transferase Activity Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Differentiation
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