CCDC9 and NCAN

		CCDC9	NCAN
Description		coiled-coil domain containing 9	neurocan
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Exon-exon Junction Complex	Extracellular Region Extracellular Space Golgi Lumen Lysosomal Lumen Synapse Perineuronal Net
	Molecular Function	RNA Binding Protein Binding	Calcium Ion Binding Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process		Skeletal System Development Cell Adhesion Central Nervous System Development
Pathways			Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS L1CAM interactions NCAM1 interactions Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs			Beta-D-Glucose Thiodigalactoside Hyaluronic acid
Diseases
GWAS		Eosinophil count ( 32888494) Refractive error ( 32231278)	Bipolar disorder ( 33263727 31043756 21353194 24618891) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 19060911 26780889) LDL cholesterol ( 26780889 18193043 19060911 19060906) Nonalcoholic fatty liver disease ( 29385134) Plateletcrit ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 23974872 29483656) Triglycerides ( 19060911 19060906 18193043)
Interacting Genes		7 interacting genes: CFTR CTBP1 HOOK1 NCAN POT1 TERF1 TINF2	13 interacting genes: CCDC9 CNTN2 GDF1 HMGB1 L1CAM NCAM1 PTN PTPRF TNC TNR ZNF121 ZNF66 ZNF99
Entrez ID		26093	1463
HPRD ID		10813	02897
Ensembl ID		ENSG00000105321	ENSG00000130287
Uniprot IDs		A0A2R8Y4Z8 B4DXW2 Q9Y3X0	O14594
PDB IDs
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomeric D-loop Disassembly Telomere Maintenance G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Chromosome, Telomeric Region RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process Chromosome Organization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding DNA Biosynthetic Process Organelle Localization Positive Regulation Of Anion Channel Activity Regulation Of DNA Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Telomeric Loop Disassembly Perinucleolar Chromocenter Positive Regulation Of Organelle Organization Positive Regulation Of Monoatomic Anion Transport 8-hydroxy-2'-deoxyguanosine DNA Binding	Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Neuron Projection Regeneration Regulation Of Axon Regeneration Regulation Of Neuron Projection Regeneration Tenascin Complex Regulation Of Response To Wounding Regulation Of Neuron Projection Development Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Neuron Projection Guidance Axon Guidance Cell Adhesion Cell Migration Synapse Organization Cell Motility Cell Surface Regulation Of Plasma Membrane Bounded Cell Projection Organization Neuron Projection Regulation Of Cell Projection Organization Regeneration Regulation Of Axonogenesis Integrin Binding Extracellular Matrix Learning Cell Junction Organization Cell-cell Adhesion Regulation Of Synaptic Plasticity Telencephalon Cell Migration Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Cellular Response To Stress Forebrain Cell Migration Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Perisynaptic Extracellular Matrix Nervous System Development Chondroitin Sulfate Proteoglycan Binding Establishment Of Protein Localization To Juxtaparanode Region Of Axon Axon Development Regulation Of Cellular Component Organization Negative Regulation Of Cell Development Learning Or Memory Regulation Of Glial Cell Differentiation Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Negative Regulation Of Cell Adhesion Negative Regulation Of Cell Differentiation Negative Regulation Of Apoptotic Cell Clearance Extracellular Matrix Of Synaptic Cleft Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development
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